A strategy for quantitative spectral imaging of tissue absorption and scattering using light emitting diodes and photodiodes

Optics Express

Volumn 17, Issue 3, 2009, Pages 1372-1384

  Lo, Justin Y ^a   Yu, Bing ^a   Fu, Henry L ^a   Bender, Janelle E ^a   Palmer, Gregory M ^b   Kuech, Thomas F ^c   Ramanujam, Nirmala ^a  

^a Duke University   (United States)

^b DUKE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c University of Wisconsin Madison   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

LIGHT EMITTING DIODES; OPTICAL FIBERS; OPTICAL PROPERTIES; PHOTODIODES; SPECTROSCOPY;

CROSSTALK ANALYSIS; DIFFUSE REFLECTANCE SPECTROSCOPY; EVOLVING SYSTEMS; SPECTRAL IMAGING; TISSUE ABSORPTION; TISSUE PHANTOM; TUNABLE SOURCE; WAVELENGTH REDUCTION;

TISSUE;

HEMOGLOBIN;

ABSORPTION; ARTICLE; COMPUTER SIMULATION; HUMAN; IMAGE QUALITY; INSTRUMENTATION; LIGHT; METABOLISM; METHODOLOGY; MONTE CARLO METHOD; OPTICS; RADIATION EXPOSURE; RADIATION SCATTERING; SPECTROSCOPY;

ABSORPTION; COMPUTER SIMULATION; HEMOGLOBINS; HUMANS; LIGHT; MONTE CARLO METHOD; OPTICS AND PHOTONICS; PHANTOMS, IMAGING; SCATTERING, RADIATION; SPECTRUM ANALYSIS;

EID: 59749102493     PISSN: None     EISSN: 10944087     Source Type: Journal    
DOI: 10.1364/OE.17.001372     Document Type: Article

References (25)

1. B.J. Moeller, R.A. Richardson, and M.W. Dewhirst, "Hypoxia and radiotherapy: opportunities for improved outcomes in cancer treatment," Cancer Metastasis Rev. 26, 241-248 (2007).
2. E.J. Moon, D.M. Brizel, J.T. Chi, and M.W. Dewhirst, "The potential role of intrinsic hypoxia markers as prognostic variables in cancer," Antioxid. Redox Signal. 9, 1237-1294 (2007).
3. A.A. Stratonnikov and V.B. Loschenov, "Evaluation of blood oxygen saturation in vivo from diffuse reflectance spectra," J. Biomed. Opt. 6, 457-467 (2001).
4. I.J. Bigio, S.G. Bown, G. Briggs, C. Kelley, S. Lakhani, D. Pickard, P.M. Ripley, I.G. Rose, and C. Saunders, "Diagnosis of breast cancer using elastic-scattering spectroscopy: preliminary clinical results," J. Biomed. Opt. 5, 221-228 (2000).
5. S.K. Chang, Y.N. Mirabal, E.N. Atkinson, D. Cox, A. Malpica, M. Follen, and R. Richards-Kortum, "Combined reflectance and fluorescence spectroscopy for in vivo detection of cervical pre-cancer," J. Biomed. Opt. 10, 024031 (2005).
6. G. Zonios, L.T. Perelman, V. Backinan, R. Manoharan, M. Fitzmaurice, J. Van Dam, and M.S. Feld, "Diffuse Reflectance Spectroscopy of Human Adenomatous Colon Polyps In Vivo," Appl. Opt. 38, 6628-6637 (1999).
7. R. Reif, O. A'Amar, and I.J. Bigio, "Analytical model of light reflectance for extraction of the optical properties in small volumes of turbid media," Appl. Opt 46, 7317-7328 (2007).
8. R. Reif, M.S. Amorosino, K.W. Calabro, O. A'Amar, S.K. Singh, and I.J. Bigio, "Analysis of changes in reflectance measurements on biological tissues subjected to different probe pressures," J. Biomed. Opt 13, 010502 (2008).
9. W.C. Lin, S.A. Toms, M. Johnson, E.D. Jansen, and A. Mahadevan-Jansen, "to vivo brain tumor demarcation using optical spectroscopy," Photochem. Photobiol. 73, 396-402 (2001).
10. A. Cerussi, D. Hsiang, N. Shah, R. Mehta, A. Durkin, J. Butler, and B.J. Tromberg, "Predicting response to breast cancer neoadjuvant chemotherapy using diffuse optical spectroscopy," Proc. Natl Acad. Sci. U.S.A. 104, 4014-4019 (2007).
11. D.B. Jakubowski, A.E. Cerussi, F. Bevilacqua, N. Shah, D. Hsiang, J. Butler, and B.J. Tromberg, "Monitoring neoadjuvant chemotherapy in breast cancer using quantitative diffuse optical spectroscopy: a case study," J. Biomed. Opt. 9, 230-238 (2004).
12. N. Shah, J. Gibbs, D. Wolverton, A. Cerussi, N. Hylton, and B.J. Tromberg, "Combined diffuse optical spectroscopy and contrast-enhanced magnetic resonance imaging for monitoring breast cancer neoadjuvant chemotherapy: a case study," J. Biomed. Opt. 10, 051503 (2005).
13. I.J. Bigio and S.G. Bown, "Spectroscopic sensing of cancer and cancer therapy: current status of translational research," Cancer Biol. Ther. 3, 259-267 (2004).
14. J. Lee, A.E. Cerussi, D. Saltzman, T. Waddington, B.J. Tromberg, and M. Brenner, "Hemoglobin measurement patterns during noninvasive diffuse optical spectroscopy monitoring of hypovolemic shock and fluid replacement," J. Biomed. Opt. 12, 024001 (2007).
15. T.J. Prefer, L.S. Matchette, C.L. Bennett, J.A. Gall, J.N. Wilke, A.J. Durkin, and M.N. Ediger, "Reflectance-based determination of optical properties in highly attenuating tissue," J. Biomed. Opt. 8, 206-215 (2003).
16. G.M. Palmer and N. Ramanujain, "Monte Carlo-based inverse model for calculating tissue optical properties. Part I: Theory and validation on synthetic phantoms," Appl. Opt. 45, 1062-1071 (2006).
17. G.M. Palmer, C. Zhu, T.M. Breslin, F. Xu, K.W. Gilchrist, and N. Ramanujam, "Monte Carlo-based inverse model for calculating tissue optical properties. Part II: Application to breast cancer diagnosis," Appl. Opt. 45, 1072-1078 (2006).
18. C. Zhu, G.M. Palmer, T.M. Breslin, J. Harter, and N. Ramanujam, "Diagnosis of breast cancer using diffuse reflectance spectroscopy: Comparison of a Monte Carlo versus partial least squares analysis based feature extraction technique," Lasers Surg. Med. 38, 714-724 (2006).
19. C. Zhu, G.M. Palmer, T.M. Breslin, F. Xu, and N. Ramanujam, "Use of a multiseparation fiber optic probe for the optical diagnosis of breast cancer," J. Biomed. Opt. 10, 024032 (2005).
20. M.C. Skala, G.M. Palmer, K.M. Vrotsos, A. Gendron-Fitzpatrick, and N. Rainanujain, "Comparison of a physical model and principal component analysis for the diagnosis of epithelial neoplasias in vivo using diffuse reflectance spectroscopy," Opt. Express. 15, 7863-7875 (2007).
21. V.T. Chang, P.S. Cartwright, S.M. Bean, G.M. Palmer, R. Bentley, and N. Ramanujam, "Quantitative physiology of the precancerous cervix in vivo via optical spectroscopy," Neoplasia, (to be published).
22. J.E. Bender, K. Vishwanath, L.K. Moore, J.Q. Brown, V. Chang, G.M. Palmer, and N. Ramanujam, "A. robust Monte Carlo model for the extraction of biological absorption and scattering in vivo," IEEE Trans. Biomed. Eng. (to be published).
23. W.F. Cheong, "Appendix to chapter 8: Summary of optical properties," Optical-Thermal Response of Laser-Irradiated Tissue. 275-303 (1995).
24. S. Prahl, "Mie scattering program," Oregon Medical Laser Center. (2005).
25. J.B. Fishkin, O. Coquoz, E.R. Anderson, M. Brenner, and B.J. Tromberg "Frequency-domain photon migration measurements of normal and malignant tissue optical properties in a human subject," Appl. Opt. 36, 10-20 (1997).