Klebsiella pneumoniae OmpA confers resistance to antimicrobial peptides

Antimicrobial Agents and Chemotherapy

Volumn 53, Issue 1, 2009, Pages 298-302

  Llobet, Enrique ^a,b   March, Catalina ^a,b   Giménez, Paloma ^b   Bengoechea, José A ^a,b,c,d,e  

^a Fundacion Caubet CIMERA Illes Balears   (Spain)

^b INSTITUTO DE SALUD CARLOS III   (Spain)

^c UNIVERSITAT DE LES ILLES BALEARS   (Spain)

^d CSIC   (Spain)

^e Recinto Hospital Joan March   (Spain)

Author keywords

[No Author keywords available]

Indexed keywords

ALPHA DEFENSIN; AMOXICILLIN; BACTERIAL POLYSACCHARIDE; CEFOTAXIME; CIPROFLOXACIN; DODECYL SULFATE SODIUM; GENTAMICIN; HUMAN NEUTROPHIL ALPHA DEFENSIN 1; IMIPENEM; NOVOBIOCIN; OUTER MEMBRANE PROTEIN A; POLYMYXIN B; POLYPEPTIDE ANTIBIOTIC AGENT; PROPIDIUM IODIDE; PROTAMINE; UNCLASSIFIED DRUG;

ANTIBIOTIC RESISTANCE; ANTIBIOTIC SENSITIVITY; ARTICLE; BACTERIAL STRAIN; CONTROLLED STUDY; CYTOTOXICITY; GENE AMPLIFICATION; GENE INSERTION; GENE SEQUENCE; KLEBSIELLA PNEUMONIAE; MINIMUM INHIBITORY CONCENTRATION; MUTAGENESIS; NONHUMAN; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN ANALYSIS; PROTEIN BINDING; PROTEIN EXPRESSION; SOUTHERN BLOTTING; WILD TYPE;

ANTI-BACTERIAL AGENTS; ANTIMICROBIAL CATIONIC PEPTIDES; BACTERIAL OUTER MEMBRANE PROTEINS; DRUG RESISTANCE; ELECTROPHORESIS, POLYACRYLAMIDE GEL; KLEBSIELLA PNEUMONIAE; MUTATION;

EID: 59749096258     PISSN: 00664804     EISSN: 10986596     Source Type: Journal    
DOI: 10.1128/AAC.00657-08     Document Type: Article

References (41)

1. Alberti, S., F. Rodriquez-Quinones, T. Schirmer, G. Rummel, J. M. Tomas, J. P. Rosenbusch, and V. J. Benedi. 1995. A porin from Klebsiella pneumoniae: sequence homology, three-dimensional model, and complement binding. Infect. Immun. 63:903-910.
2. Alexeyev, M. F. 1999. The pKNOCK series of broad-host-range mobilizable suicide vectors for gene knockout and targeted DNA insertion into the chromosome of gram-negative bacteria. BioTechniques 26:824-826, 828.
3. Belaaouaj, A., K. S. Kim, and S. D. Shapiro. 2000. Degradation of outer membrane protein A in Escherichia coli killing by neutrophil elastase. Science 289:1185-1188.
4. Bengoechea, J. A., H. Najdenski, and M. Skurnik. 2004. Lipopolysaccharide O antigen status of Yersinia enterocolitica O:8 is essential for virulence and absence of O antigen affects the expression of other Yersinia virulence factors. Mol. Microbiol. 52:451-469.
5. Brogden, K. A. 2005. Antimicrobial peptides: pore formers or metabolic inhibitors in bacteria? Nat. Rev. Microbiol. 3:238-250.
6. Campos, M. A., P. Morey, and J. A. Bengoechea. 2006. Quinolones sensitize gram-negative bacteria to antimicrobial peptides. Antimicrob. Agents Chemother. 50:2361-2367.
7. Campos, M. A., M. A. Vargas, V. Regueiro, C. M. Llompart, S. Alberti, and J. A. Bengoechea. 2004. Capsule polysaccharide mediates bacterial resistance to antimicrobial peptides. Infect. Immun. 72:7107-7114.
8. Choi, K. H., J. B. Gaynor, K. G. White, C. Lopez, C. M. Bosio, R. R. Karkhoff-Schweizer, and H. P. Schweizer. 2005. A Tn7-based broad-range bacterial cloning and expression system. Nat. Methods 2:443-448.
9. Crouch, M. L., L. A. Becker, I. S. Bang, H. Tanabe, A. J. Ouellette, and F. C. Fang. 2005. The alternative sigma factor sigma is required for resistance of Salmonella enterica serovar Typhimurium to anti-microbial peptides. Mol. Microbiol. 56:789-799.
10. Datsenko, K. A., and B. L. Wanner. 2000. One-step inactivation of chromosomal genes in Escherichia coli K-12 using PCR products. Proc. Natl. Acad. Sci. USA 97:6640-6645.
11. Domenech-Sanchez, A., L. Martinez-Martinez, S. Hernandez-Alles, C. M. del Carmen, A. Pascual, J. M. Tomas, S. Alberti, and V. J. Benedi. 2003. Role of Klebsiella pneumoniae OmpK35 porin in antimicrobial resistance. Antimicrob. Agents Chemother. 47:3332-3335.
12. Fresno, S., N. Jimenez, L. Izquierdo, S. Merino, M. M. Corsaro, C. C. De, M. Parrilli, T. Naldi, M. Regue, and J. M. Tomas. 2006. The ionic interaction of Klebsiella pneumoniae K2 capsule and core lipopolysaccharide. Microbiology 152:1807-1818.
13. Frirdich, E., C. Bouwman, E. Vinogradov, and C. Whitfield. 2005. The role of galacturonic acid in outer membrane stability in Klebsiella pneumoniae. J. Biol. Chem. 280:27604-27612.
14. Hancock, R. E. 1997. Peptide antibiotics. Lancet 349:418-422.
15. Hancock, R. E., and G. Diamond. 2000. The role of cationic antimicrobial peptides in innate host defences. Trends Microbiol. 8:402-410.
16. Hancock, R. E., and M. G. Scott. 2000. The role of antimicrobial peptides in animal defenses. Proc. Natl. Acad. Sci. USA 97:8856-8861.
17. Hancock, R. E. W., and D. S. Chapple. 1999. Peptide antibiotics. Antimicrob. Agents Chemother. 43:1317-1323.
18. Hari-Dass, R., C. Shah, D. J. Meyer, and J. G. Raynes. 2005. Serum amyloid A protein binds to outer membrane protein A of gram-negative bacteria. J. Biol. Chem. 280:18562-18567.
19. Hernandez-Alles, S., S. Alberti, D. Alvarez, A. Domenech-Sanchez, L. Martinez-Martinez, J. Gil, J. M. Tomas, and V. J. Benedi. 1999. Porin expression in clinical isolates of Klebsiella pneumoniae. Microbiology 145:673-679.
20. Humphreys, S., A. Stevenson, A. Bacon, A. B. Weinhardt, and M. Roberts. 1999. The alternative sigma factor, σE, is critically important for the virulence of Salmonella typhimurium. Infect. Immun. 67:1560-1568.
21. Jeannin, P., G. Magistrelli, L. Goetsch, J. F. Haeuw, N. Thieblemont, J. Y. Bonnefoy, and Y. Delneste. 2002. Outer membrane protein A (OmpA): a new pathogen-associated molecular pattern that interacts with antigen presenting cells - impact on vaccine strategies. Vaccine 20(Suppl. 4):A23-A27.
22. Lin, J., S. Huang, and Q. Zhang. 2002. Outer membrane proteins: key players for bacterial adaptation in host niches. Microbes Infect. 4:325-331.
23. Mathur, J., B. M. Davis, and M. K. Waldor. 2007. Antimicrobial peptides activate the Vibrio cholerae sigmaE regulon through an OmpU-dependent signalling pathway. Mol. Microbiol. 63:848-858.
24. Mecsas, J., P. E. Rouviere, J. W. Erickson, T. J. Donohue, and C. A. Gross. 1993. The activity of sigma E, an Escherichia coli heat-inducible sigma-factor, is modulated by expression of outer membrane proteins. Genes Dev. 7:2618-2628.
25. Mehrad, B., and T. J. Standiford. 1999. Role of cytokines in pulmonary antimicrobial host defense. Immunol. Res. 20:15-27.
26. Nassif, X., J. M. Fournier, J. Arondel, and P. J. Sansonetti. 1989. Mucoid phenotype of Klebsiella pneumoniae is a plasmid-encoded virulence factor. Infect. Immun. 57:546-552.
27. Nicolas, P., and A. Mor. 1995. Peptides as weapons against microorganisms in the chemical defence system of vertebrates. Annu. Rev. Microbiol. 49:277-304.
28. Nikaido, H., and M. Vaara. 1985. Molecular basis of bacterial outer membrane permeability. Microbiol. Rev. 49:1-32.
29. Nizet, V. 2006. Antimicrobial peptide resistance mechanisms of human bacterial pathogens. Curr. Issues Mol. Biol. 8:11-26.
30. Peschel, A. 2002. How do bacteria resist human antimicrobial peptides? Trends Microbiol. 10:179-186.
31. Prasadarao, N. V., A. M. Blom, B. O. Villoutreix, and L. C. Linsangan. 2002. A novel interaction of outer membrane protein A with C4b binding protein mediates serum resistance of Escherichia coli K1. J. Immunol. 169:6352-6360.
32. Prasadarao, N. V., C. A. Wass, J. N. Weiser, M. F. Stins, S. H. Huang, and K. S. Kim. 1996. Outer membrane protein A of Escherichia coli contributes to invasion of brain microvascular endothelial cells. Infect. Immun. 64:146-153.
33. Rahn, A., and C. Whitfield. 2003. Transcriptional organization and regulation of the Escherichia coli K30 group 1 capsule biosynthesis (cps) gene cluster. Mol. Microbiol. 47:1045-1060.
34. Sahly, H., and R. Podschun. 1997. Clinical, bacteriological, and serological aspects of Klebsiella infections and their spondylarthropathic sequelae. Clin. Diagn. Lab. Immunol. 4:393-399.
35. Shah, C., R. Hari-Dass, and J. G. Raynes. 2006. Serum amyloid A is an innate immune opsonin for Gram-negative bacteria. Blood 108:1751- 1757.
36. Sukumaran, S. K., H. Shimada, and N. V. Prasadarao. 2003. Entry and intracellular replication of Escherichia coli K1 in macrophages require expression of outer membrane protein A. Infect. Immun. 71:5951-5961.
37. Timko, J. 2004. Changes of antimicrobial resistance and extended-spectrum beta-lactamase production in Klebsiella spp. strains. J. Infect. Chemother. 10:212-215.
38. Vaara, M. 1992. Agents that increase the permeability of the outer membrane. Microbiol. Rev. 56:395-411.
39. Vogel, J., and K. Papenfort. 2006. Small non-coding RNAs and the bacterial outer membrane. Curr. Opin. Microbiol. 9:605-611.
40. Wu, H., A. Kuzmenko, S. Wan, L. Schaffer, A. Weiss, J. H. Fisher, K. S. Kim, and F. X. McCormack. 2003. Surfactant proteins A and D inhibit the growth of Gram-negative bacteria by increasing membrane permeability. J. Clin. Investig. 111:1589-1602.
41. Yi, E. C., and M. Hackett. 2000. Rapid isolation method for lipopolysaccharide and lipid A from gram-negative bacteria. Analyst 125:651-656.