Antiviral cellular immunity in colorectal cancer patients

Human Immunology

Volumn 70, Issue 2, 2009, Pages 85-88

  Kiewe, Philipp ^a   Wojtke, Susanne ^a   Thiel, Eckhard ^a   Nagorsen, Dirk ^a,b  

^a CHARITÉ UNIVERSITÄTSMEDIZIN BERLIN   (Germany)

^b MICROMET AG   (Germany)

Author keywords

Adaptive immunity; Colorectal cancer; Immunotherapy; T cell response; Viral antigens

Indexed keywords

HLA A2 ANTIGEN;

ADAPTIVE IMMUNITY; ADULT; AGED; ARTICLE; CANCER PATIENT; CELLULAR IMMUNITY; CLINICAL ARTICLE; COLORECTAL CANCER; CONTROLLED STUDY; CYTOMEGALOVIRUS; HUMAN; HUMAN CELL; INFLUENZA VIRUS; PRIORITY JOURNAL; T LYMPHOCYTE;

ADULT; AGED; AGED, 80 AND OVER; ANTIBODIES, VIRAL; CELL COUNT; COLORECTAL NEOPLASMS; CYTOMEGALOVIRUS; FEMALE; HUMANS; IMMUNITY, CELLULAR; MALE; MIDDLE AGED; ORTHOMYXOVIRIDAE; T-LYMPHOCYTES; YOUNG ADULT;

EID: 59649126205     PISSN: 01988859     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.humimm.2008.12.004     Document Type: Article

References (22)

1. Nagorsen D., Keilholz U., Rivoltini L., Schmittel A., Letsch A., Asemissen A.M., et al. Natural T-cell response against MHC class I epitopes of epithelial cell adhesion molecule, her-2/neu, and carcinoembryonic antigen in patients with colorectal cancer. Cancer Res 60 (2000) 4850-4854
2. Nagorsen D., Scheibenbogen C., Marincola F.M., Letsch A., and Keilholz U. Natural T-cell immunity against cancer. Clin Cancer Res 9 (2003) 4296-4303
3. Nagorsen D., Scheibenbogen C., Letsch A., Germer C.T., Buhr H.J., Hegewisch-Becker S., et al. T-cell responses against tumor associated antigens and prognosis in colorectal cancer patients. J Transl Med 3 (2005) 3
4. Nagorsen D., and Thiel E. Clinical and immunologic responses to active specific cancer vaccines in human colorectal cancer. Clin Cancer Res 12 (2006) 3064-3069
5. Altman J.D., Moss P.A., Goulder P.J., Barouch D.H., McHeyzer-Williams M.G., Bell J.I., et al. Phenotypic analysis of antigen-specific T lymphocytes. Science 274 (1996) 94-96
6. Solache A., Morgan C.L., Dodi A.I., Morte C., Scott I., Baboonian C., et al. Identification of three HLA-A*0201-restricted cytotoxic T-cell epitopes in the cytomegalovirus protein pp65 that are conserved between eight strains of the virus. J Immunol 163 (1999) 5512-5518
7. Gotch F., Rothbard J., Howland K., Townsend A., and McMichael A. Cytotoxic T lymphocytes recognize a fragment of influenza virus matrix protein in association with HLA-A2. Nature 326 (1987) 881-882
8. Bednarek M.A., Sauma S.Y., Gammon M.C., Porter G., Tamhankar S., Williamson A.R., et al. The minimum peptide epitope from the influenza virus matrix protein. Extra and intracellular loading of HLA-A2. J Immunol 147 (1991) 4047-4053
9. Morrison J., Elvin J., Latron F., Gotch F., Moots R., Strominger J.L., et al. Identification of the nonamer peptide from influenza A matrix protein and the role of pockets of HLA-A2 in its recognition by cytotoxic T lymphocytes. Eur J Immunol 22 (1992) 903-907
10. Robbins P.A., Garboczi D.N., and Strominger J.L. HLA-A*0201 complexes with two 10-Mer peptides differing at the P2 anchor residue have distinct refolding kinetics. J Immunol 154 (1995) 703-709
11. Malmberg K.J. Effective immunotherapy against cancer: A question of overcoming immune suppression and immune escape?. Cancer Immunol Immunother 53 (2004) 879-892
12. Grubeck-Loebenstein B., and Wick G. The aging of the immune system. Adv Immunol 80 (2002) 243-284
13. Weinberger B., Herndler-Brandstetter D., Schwanninger A., Weiskopf D., and Grubeck-Loebenstein B. Biology of immune responses to vaccines in elderly persons. Clin Infect Dis 46 (2008) 1078-1084
14. Kang I., Hong M.S., Nolasco H., Park S.H., Dan J.M., Choi J.Y., et al. Age-associated change in the frequency of memory CD4+ T cells impairs long term CD4+ T-cell responses to influenza vaccine. J Immunol 173 (2004) 673-681
15. Khan N., Hislop A., Gudgeon N., Cobbold M., Khanna R., Nayak L., et al. Herpesvirus-specific CD8 T-cell immunity in old age: Cytomegalovirus impairs the response to a coresident EBV infection. J Immunol 173 (2004) 7481-7489
16. Deng Y., Jing Y., Campbell A.E., and Gravenstein S. Age-related impaired type 1 T-cell responses to influenza: Reduced activation ex vivo, decreased expansion in CTL culture in vitro, and blunted response to influenza vaccination in vivo in the elderly. J Immunol 172 (2004) 3437-3446
17. Sandherr M., Einsele H., Hebart H., Kahl C., Kern W., Kiehl M., et al., Infectious Diseases Working Party, German Society for Hematology and Oncology. Antiviral prophylaxis in patients with haematological malignancies and solid tumours: Guidelines of the Infectious Diseases Working Party (AGIHO) of the German Society for Hematology and Oncology (DGHO). Ann Oncol 17 (2006) 1051-1059
18. Ferrone S., and Whiteside T.L. Tumor microenvironment and immune escape. Surg Oncol Clin North Am 16 (2007) 755-774
19. Evans C., Dalgleish A.G., and Kumar D. Review article: Immune suppression and colorectal cancer. Aliment Pharmacol Ther 24 (2006) 1163-1177
20. He X.S., Mahmood K., Maecker H.T., Holmes T.H., Kemble G.W., Arvin A.M., et al. Analysis of the frequencies and of the memory T-cell phenotypes of human CD8+ T cells specific for influenza A viruses. J Infect Dis 187 (2003) 1075-1084
21. Letsch A., Knoedler M., Na I.K., Kern F., Asemissen A.M., Keilholz U., et al. CMV-specific central memory T cells reside in bone marrow. Eur J Immunol 37 (2007) 3063-3068
22. Engstrand M., Lidehall A.K., Totterman T.H., Herrman B., Eriksson B.M., and Korsgren O. Cellular responses to cytomegalovirus in immunosuppressed patients: Circulating CD8+ T cells recognizing CMVpp65 are present but display functional impairment. Clin Exp Immunol 132 (2003) 96-104