CMV-specific central memory T cells reside in bone marrow

European Journal of Immunology

Volumn 37, Issue 11, 2007, Pages 3063-3068

  Letsch, Anne ^a   Knoedler, Maren ^a   Na, Il Kang ^a   Kern, Florian ^a   Asemissen, Anne Marie ^a   Keilholz, Ulrich ^a   Loesch, Michael ^b   Thiel, Eckhard ^a   Volk, Hans Dieter ^a,c   Scheibenbogen, Carmen ^a  

^a CHARITÉ UNIVERSITÄTSMEDIZIN BERLIN   (Germany)

^b Auguste Viktoria Klinikum   (Germany)

^c Berlin Brandenburg Center for Regenerative Therapies   (Germany)

Author keywords

Bone marrow; Central memory T cells; CMV

Indexed keywords

CD45RA ANTIGEN; CHEMOKINE RECEPTOR CCR7; CYTOKINE; CYTOMEGALOVIRUS ANTIGEN PP65; TETRAMER;

ARTICLE; BONE MARROW; CD8+ T LYMPHOCYTE; CELL ISOLATION; CELLULAR IMMUNITY; CONTROLLED STUDY; CYTOMEGALOVIRUS; HUMAN; HUMAN CELL; HUMAN TISSUE; IMMUNE RESPONSE; IN VITRO STUDY; LYMPHOCYTE DIFFERENTIATION; LYMPHOCYTE FUNCTION; LYMPHOCYTE PROLIFERATION; MEMORY T LYMPHOCYTE; PERIPHERAL BLOOD MONONUCLEAR CELL; PRIORITY JOURNAL; T LYMPHOCYTE ACTIVATION; TOTAL HIP PROSTHESIS;

AGED; AGED, 80 AND OVER; BONE MARROW CELLS; CD8-POSITIVE T-LYMPHOCYTES; CELL DIFFERENTIATION; CYTOMEGALOVIRUS; CYTOMEGALOVIRUS INFECTIONS; FEMALE; FLOW CYTOMETRY; HUMANS; IMMUNOLOGIC MEMORY; MALE; MIDDLE AGED; PHOSPHOPROTEINS; T-LYMPHOCYTE SUBSETS; VIRAL MATRIX PROTEINS;

EID: 36249028185     PISSN: 00142980     EISSN: None     Source Type: Journal    
DOI: 10.1002/eji.200636930     Document Type: Article

References (34)

1. Sallusto, F., Geginat, J. and Lanzavecchia, A., Central memory and effector memory T cell subsets: Function, generation, and maintenance. Annu. Rev. Immunol. 2004. 22: 745-763.
2. Kaech, S. M., Wherry, E. J. and Ahmed, R., Effector and memory T-cell differentiation: Implications for vaccine development. Nat. Rev. Immunol. 2002. 2: 251-262.
3. + memory T-cell subsets in response to antigen or homeostatic cytokines. Blood 2003. 101: 4260-4266.
4. Sallusto, F., Lenig, D., Forster, R., Lipp, M. and Lanzavecchia, A., Two subsets of memory T lymphocytes with distinct homing potentials and effector functions. Nature 1999. 401: 708-712.
5. Wherry, E. J., Teichgraber, V., Becker, T. C., Masopust, D., Kaech, S. M., Antia, R., von Andrian, U. H. and Ahmed, R., Lineage relationship and protective immunity of memory CD8 T cell subsets. Nat Immunol. 2003. 4: 225-234.
6. Zaph, C., Uzonna, J., Beverley, S.M. and Scott, P., Central memory T cells mediate long-term immunity to Leishmania major in the absence of persistent parasites. Nat. Med. 2004. 10: 1104-1110.
7. Seaman M. S., Peyerl, F. W., Jackson, S. S., Lifton, M. A., Gorgone, D. A., Schmitz, J. E. and Letvin, N. L., Subsets of memory cytotoxic T lymphocytes elicited by vaccination influence the efficiency of secondary expansion in vivo. J. Virol. 2004. 78: 206-215.
8. + T cells vary in differentiation phenotype in different persistent virus infections. Nat. Med. 2002. 8: 379-385.
9. Champagne, P., Ogg, G. S., King, A. S., Knabenhans, C., Ellefsen, K., Nobile, M., Appay, V. et al., Skewed maturation of memory HIV-specific CD8 T lymphocytes. Nature 2001. 410: 106-111.
10. Ellefsen, K., Harari, A., Champagne, P., Bart, P. A., Sekaly, R. P. and Pantaleo, G., Distribution and functional analysis of memory antiviral CD8 T cell responses in HIV-1 and cytomegalovirus infections. Eur. J. Immunol. 2002. 32: 3756-3764.
11. Gamadia, L. E., Rentenaar, R. J., Baars, P. A., Remmerswaal, E. B., Surachno, S., Weel, J. F., Toebes, M. et al., Differentiation of cytomegalovirus-specific CD8 (+) T cells in healthy and immunosuppressed virus carriers. Blood 2001. 98: 754-761.
12. Di Rosa, F. and Pabst, R., The bone marrow: A nest for migratory memory T cells. Trends Immunol. 2005. 26: 360-366.
13. Di Rosa, F. and Santord, A., Memory T-cell competition for bone marrow seeding. Immunology 2003. 108: 296-304.
14. Becker, T. C., Coley, S. M., Wherry, E. J. and Ahmed, R., Bone marrow is a preferred site for homeostatic proliferation of memory CD8 T cells. J. Immunol. 2005.174: 1269-1273.
15. Feuerer, M., Rocha, M., Bai, L., Uman ky, V., Solomayer, E. F., Bastert, G., Diel, I.J. and Schirrmacher, V., Enrichment of memory T cells and other profound immunological changes in the bone marrow from untreated breast cancer patients. Int. J. Cancer 2001. 92: 96-105.
16. Cavanagh, I. L., Bonasio, R., Mazo, I. B., Halin, C., Cheng, G., van der Velden, A. W., Cariappa, A. et al., Activation of bone marrow-resident memory T cells by circulating, antigen-bearing dendritic cells. Nat. Immunol. 2005. 6: 1029-1037.
17. Zhang, X., Dong, H., Lin, W., Voss, S., Hinkley, L, Westergren, M., Tian, G. et al., Human bone marrow: A reservoir for "enhanced effector memory" CD8± Tcells with potent recall function. J. Immunol. 2006. 177: 6730-6737.
18. Appay, V. and Rowland-Jones, S. L., Lessons from the study of T-cell differentiation in persistent human virus infection. Semin. Immunol. 2004. 16: 205-212.
19. Chen, G., Shankar, P., Lange, C., Valdez, H., Skolnik, P. R., Wu, L., Manjunath, N. and Lieberman, J., CD8 T cells specific for human immunodeficiency virus, Epstein-Barr virus, and cytomegalovirus lack molecules for homing to lymphoid sites of infection. Blood 2001. 98: 156-164.
20. - subsets suggest differentiation independent of CD45RA expression. Blood 2007 109: 2863-2870.
21. + T cells upon antigenic stimulation. Int. Immunol. 2005 17: 713-719.
22. Mazo, I. B., Honczarenko, M., Leung, H., Cavanagh, L. L., Bonasio, R., Weninger, W., Engelke, K. et al., Bone marrow is a major reservoir and site of recruitment for central memory CD8(+) T cells. Immunity 2005. 22: 259-270.
23. 8 memory T cells. Cancer Res. 2003. 63: 5582-5586.
24. Letsch, A., Keilholz, U., Kern, F., Asemissen, A. M., Thiel, E. and Scheibenbogen, C., Specific central memory T cells in the bone marrow of patients immunized against tyrosinase peptides. J. Immunother. 2006. 29: 201-207.
25. Odendahl, M., Mei, H., Hoyer, B. F., Jacobi, A. M., Hansen, A., Muehlinghaus, G., Berek, C. et al., Generation of migratory antigen-specific plasma blasts and mobilization of resident plasma cells in a secondary immune response. Blood 2005. 105: 1614-1621.
26. Parretta, E., Cassese, G., Barba, P., Santoni, A., Guardiola, J. and Di Rosa, F., CD8 cell division maintaining cytotoxic memory occurs predominantly in the bone marrow. J. Immunol. 2005. 174: 7654-7664.
27. + T cells in response to viral infections of the lung and skin. Eur. J. Immunol. 2006. 36: 327-333.
28. Zammit, D. J., Cauley, L. S., Pham, Q. M. and Lefrancois, L., Dendritic cells maximize the memory CD8 T cell response to infection. Immunity. 2005. 22: 561-570.
29. Feuerer, M., Beckhove, P., Garbi, N., Mahnke, Y., Timmer, A., Hommel, M., Hammerling, G. J. et al., Bone marrow as a priming site for T-cell responses to blood-borne antigen. Nat. Med. 2003. 9: 1151-1157.
30. Dudley, M. E., Wunderlich, J. R., Yang, J. C., Hwu, P., Schwartzentruber, D. J., Topalian, S. L., Sherry, R. M. et al., A phase I study of nonmyeloablative chemotherapy and adoptive transfer of autologous tumor antigen-specific T lymphocytes in patients with metastatic melanoma. J. Immunother. 2002. 25: 243-251.
31. + T cell clones for the treatment of patients with metastatic melanoma: In vivo persistence, migration, and antitumor effect of transferred T cells. Proc. Natl. Acad. Sci. USA 2002. 99: 16168-16173.
32. + T cell expansion and function. J. Exp. Med. 2005. 201: 139-148.
33. Asemissen, A. M., Keilholz, U., Tenzer, S., Millier, M., Walter, S., Stevanovic, S., Schild, H. et al., Identification of a highly immunogenic HLA-A*01-binding T cell epitope of WT1. Clin. Cancer Res. 2006. 12: 7476-7482.
34. - effector subset exerting ex-vivo tumor-specific cytolytic activity. Cancer Res. 2002. 62: 1743-1750.