UNC-6 (netrin) orients the invasive membrane of the anchor cell in C. elegans

Nature Cell Biology

Volumn 11, Issue 2, 2009, Pages 183-189

  Ziel, Joshua W ^a   Hagedorn, Elliott J ^a   Audhya, Anjon ^b   Sherwood, David R ^a,c  

^a DUKE UNIVERSITY   (United States)

^b UNIVERSITY OF WISCONSIN SCHOOL OF MEDICINE AND PUBLIC HEALTH   (United States)

^c DUKE UNIVERSITY MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

NETRIN;

ANIMAL CELL; ARTICLE; BASEMENT MEMBRANE; CAENORHABDITIS ELEGANS; CELL ANCHORAGE; CELL FUNCTION; CELL INVASION; CELL POLARITY; CONTROLLED STUDY; DEVELOPMENTAL STAGE; GENE EXPRESSION REGULATION; GENE FUNCTION; GENE INTERACTION; GENE LOCATION; GENE MUTATION; GENE TARGETING; NONHUMAN; PRIORITY JOURNAL; VENTRAL ROOT;

ACTINS; ANIMALS; ANIMALS, GENETICALLY MODIFIED; BASEMENT MEMBRANE; CAENORHABDITIS ELEGANS; CAENORHABDITIS ELEGANS PROTEINS; CELL ADHESION MOLECULES; CELL MEMBRANE; CELL POLARITY; FEMALE; GENITALIA, FEMALE; MODELS, ANIMAL; NEOPLASM INVASIVENESS; NERVE TISSUE PROTEINS; PHOSPHATIDYLINOSITOL 4,5-DIPHOSPHATE; SIGNAL TRANSDUCTION; STEM CELLS;

CAENORHABDITIS ELEGANS;

EID: 59649126135     PISSN: 14657392     EISSN: None     Source Type: Journal    
DOI: 10.1038/ncb1825     Document Type: Article

References (29)

1. Machesky, L., Jurdic, P. & Hinz, B. Grab, stick, pull and digest: The functional diversity of actin-associated matrix-adhesion structures. Workshop on invadopodia, podosomes and focal adhesions in tissue invasion. EMBO Rep. 9, 139-143 (2008).
2. Even-Ram, S. & Yamada, K. M. Cell migration in 3D matrix. Curr. Opin. Cell Biol. 17, 524-532 (2005).
3. Hotary, K., Li, X. Y., Allen, E., Stevens, S. L. & Weiss, S. J. A cancer cell metalloprotease triad regulates the basement membrane transmigration program. Genes Dev. 20, 2673-2686 (2006).
4. Sharma-Kishore, R., White, J. G., Southgate, E. & Podbilewicz, B. Formation of the vulva in Caenorhabditis elegans: A paradigm for organogenesis. Development 126, 691-699 (1999).
5. Sherwood, D. R. & Sternberg, P. W. Anchor cell invasion into the vulval epithelium in C. elegans. Dev. Cell 5, 21-31 (2003).
6. Hwang, B. J., Meruelo, A. D. & Sternberg, P. W. C. elegans EVI1 proto-oncogene, EGL-43, is necessary for Notch-mediated cell fate specification and regulates cell invasion. Development 134, 669-679 (2007).
7. Rimann, I. & Hajnal, A. Regulation of anchor cell invasion and uterine cell fates by the egl-43 Evi-1 proto-oncogene in Caenorhabditis elegans. Dev. Biol. 308, 187-195 (2007).
8. Sherwood, D. R., Butler, J. A., Kramer, J. M. & Sternberg, P. W. FOS-1 promotes basement-membrane removal during anchor-cell invasion in C. elegans. Cell 121, 951-962 (2005).
9. Baker, K. A., Moore, S. W., Jarjour, A. A. & Kennedy, T. E. When a diffusible axon guidance cue stops diffusing: Roles for netrins in adhesion and morphogenesis. Curr. Opin. Neurobiol. 16, 529-534 (2006).
10. Hedgecock, E. M., Culotti, J. G. & Hall, D. H. The unc-5, unc-6, and unc-40 genes guide circumferential migrations of pioneer axons and mesodermal cells on the epidermis in C. elegans. Neuron 4 61-85 (1990).
11. Asakura, T., Ogura, K. & Goshima, Y. UNC-6 expression by the vulval precursor cells Caenorhabditis elegans is required for the complex axon guidance of the HSN neurons. Dev. Biol. 304, 800-810 (2007).
12. Wadsworth, W. G., Bhatt, H. & Hedgecock, E. M. Neuroglia and pioneer neurons express UNC-6 to provide global and local netrin cues for guiding migrations in C. elegans. Neuron 16, 35-46 (1996).
13. Burdine, R. D., Branda, C. S. & Stern, M. J. EGL-17(FGF) expression coordinates the attraction of the migrating sex myoblasts with vulval induction in C. elegans. Development 125, 1083-1093 (1998).
14. Adler, C. E., Fetter, R. D. & Bargmann, C. I. UNC-6/netrin induces neuronal asymmetry and defines the site of axon formation. Nature Neurosci. 9, 511-518 (2006).
15. Gitai, Z., Yu, T. W., Lundquist, E. A., Tessier-Lavigne, M. & Bargmann, C. I. The netrin receptor UNC-40/DCC stimulates axon attraction and outgrowth through enabled and, in parallel, Rac and UNC-115/AbLIM. Neuron 37, 53-65 (2003).
16. Lundquist, E. A., Reddien, P. W., Hartwieg, E., Horvitz, H. R. & Bargmann, C. I. Three C. elegans Rac proteins and several alternative Rac regulators control axon guidance, cell migration and apoptotic cell phagocytosis. Development 128, 4475-4488 (2001).
17. Edwards, K. A., Demsky, M., Montague, R. A., Weymouth, N. & Kiehart, D. P. GFPmoesin illuminates actin cytoskeleton dynamics in living tissue and demonstrates cell shape changes during morphogenesis in Drosophila. Dev. Biol. 191, 103-117 (1997).
18. Janmey, P. A. & Lindberg, U. Cytoskeletal regulation: Rich in lipids. Nature Rev. Mol. Cell Biol. 5, 658-666 (2004).
19. Heo, W. D. et al. PI(3, 4, 5)P3 and PI(4, 5)P2 lipids target proteins with polybasic clusters to the plasma membrane. Science 314, 1458-1461 (2006).
20. Rescher, U., Ruhe, D., Ludwig, C., Zobiack, N. & Gerke, V. Annexin 2 is a phosphatidylinositol (4, 5)-bisphosphate binding protein recruited to actin assembly sites cellular membranes. J. Cell Sci. 117, 3473-3480 (2004).
21. Colon-Ramos, D. A., Margeta, M. A. & Shen, K. Glia promote local synaptogenesis through UNC-6 (netrin) signalling in C. elegans. Science 318, 103-106 (2007).
22. Fitamant, J. et al. Netrin-1 expression confers a selective advantage for tumour cell survival in metastatic breast cancer. Proc. Natl Acad. Sci. USA 105, 4850-4855 (2008).
23. Rodrigues, S., De Wever, O., Bruyneel, E., Rooney, R. J. & Gespach, C. Opposing roles of netrin-1 and the dependence receptor DCC in cancer cell invasion, tumour growth and metastasis. Oncogene 26, 5615-5625 (2007).
24. Nguyen, A. & Cai, H. Netrin-1 induces angiogenesis via a DCC-dependent ERK1/2-eNOS feed-forward mechanism. Proc. Natl Acad. Sci. USA 103, 6530-6535 (2006).
25. Park, K. W. et al. The axonal attractant Netrin-1 is an angiogenic factor. Proc. Natl Acad. Sci. USA 101, 16210-16215 (2004).
26. Wilson, B. D. et al. Netrins promote developmental and therapeutic angiogenesis. Science 313, 640-644 (2006).
27. Heissig, B., Hattori, K., Friedrich, M., Rafii, S. & Werb, Z. Angiogenesis: Vascular remodelling of the extracellular matrix involves metalloproteinases. Curr. Opin. Haematol. 10, 136-141 (2003).
28. Kao, G., Huang, C. C., Hedgecock, E. M., Hall, D. H. & Wadsworth, W. G. The role the laminin beta subunit in laminin heterotrimer assembly and basement membrane function and development in C. elegans. Dev. Biol. 290, 211-219 (2006).
29. Hobert, O. PCR fusion-based approach to create reporter gene constructs for expression analysis in transgenic C. elegans. Biotechniques 32, 728-730 (2002).