Inhaled insulin does not trigger lung inflammation and airway remodelling

European Respiratory Journal

Volumn 33, Issue 2, 2009, Pages 444-445

  Papagianni, M ^a   Hatziefthimiou, A ^a   Chachami, G ^a   Gourgoulianis, K ^a   Molyvdas, P A ^a   Paraskeva, E ^a  

^a UNIVERSITY OF THESSALY   (Greece)

Author keywords

[No Author keywords available]

Indexed keywords

HUMAN INSULIN; RECOMBINANT HUMAN INSULIN;

AIRWAY; CELL PROLIFERATION; CYTOKINE PRODUCTION; DIABETES MELLITUS; DRUG EFFECT; HUMAN; LETTER; LUNG FUNCTION; MUSCLE FIBER CONTRACTION; MYOFIBROBLAST; PNEUMONIA; PRIORITY JOURNAL; RESPIRATORY EPITHELIUM; SMOOTH MUSCLE FIBER;

ADMINISTRATION, INHALATION; BRONCHOALVEOLAR LAVAGE FLUID; BRONCHOSCOPY; CLINICAL TRIALS AS TOPIC; HUMANS; HYPOGLYCEMIC AGENTS; INFLAMMATION; INSULIN; LUNG; PHENOTYPE; RISK FACTORS;

EID: 59649124815     PISSN: 09031936     EISSN: 13993003     Source Type: Journal    
DOI: 10.1183/09031936.00140708     Document Type: Letter

References (4)

1. Liu MC, Riese RJ, Van Grundy K, et al. Effects of inhaled human insulin on airway lining fluid composition in adults with diabetes. Eur Respir J 2008; 32: 180-188.
2. Halayko AJ, Amrani Y. Mechanisms of inflammation-mediated airway smooth muscle plasticity and airway remodeling in asthma. Respir Physiol Neurobiol 2003; 137:209-222.
3. Halayko AJ, Solway J. Plasticity in skeletal, cardiac, and smooth muscle: invited review: molecular mechanisms of phenotypic plasticity in smooth muscle cells. J Appl Physiol 2001; 90: 358-368.
4. Papagianni M, Hatziefthimiou A, Chachami G, Gourgoulianis K, Molyvdas P-A, Paraskeva E. Insulin causes a transient induction of proliferation via activation of the PI3-kinase pathway in airway smooth muscle cells. Exp Clin Endocrinol Diabetes 2007; 115: 118-123.