Insulin causes a transient induction of proliferation via activation of the PI3-kinase pathway in airway smooth muscle cells

Experimental and Clinical Endocrinology and Diabetes

Volumn 115, Issue 2, 2007, Pages 118-123

  Papagianni, M ^a   Hatziefthimiou, A ^a   Chachami, G ^a   Gourgoulianis, K ^a   Molyvdas, P A ^a   Paraskeva, E ^a  

^a UNIVERSITY OF THESSALY   (Greece)

Author keywords

Diabetes; Protein kinases; Signal transduction

Indexed keywords

2 MORPHOLINO 8 PHENYLCHROMONE; BOVINE SERUM ALBUMIN; INSULIN; MITOGEN ACTIVATED PROTEIN KINASE; PHOSPHATIDYLINOSITOL 3 KINASE; WORTMANNIN;

ANIMAL CELL; ARTICLE; BREATHING MUSCLE; CELL COUNT; CELL PROLIFERATION; CONTROLLED STUDY; DRUG MECHANISM; ENZYME ACTIVATION; NONHUMAN; PRIORITY JOURNAL; RABBIT; SIGNAL TRANSDUCTION; SMOOTH MUSCLE FIBER;

1-PHOSPHATIDYLINOSITOL 3-KINASE; ANIMALS; CELL PROLIFERATION; CELLS, CULTURED; INSULIN; MAP KINASE SIGNALING SYSTEM; MYOCYTES, SMOOTH MUSCLE; RABBITS; RESPIRATORY MUSCLES; SIGNAL TRANSDUCTION;

EID: 33947125631     PISSN: 09477349     EISSN: None     Source Type: Journal    
DOI: 10.1055/s-2007-967094     Document Type: Article

References (31)

1. Ammit AJ, Panettieri RA Jr: Signal transduction in smooth muscle: invited review: the circle of life: cell cycle regulation in airway smooth muscle. J Appl Physiol 2001; 91: 1431-1437
2. Avena R, Mitchell ME, Neville RF, Sidawy AN: The additive effects of glucose and insulin on the proliferation of infragenicular vascular smooth muscle cells. J Vasc Surg 1998; 28: 1033-1038
3. Begum N, Song Y, Rienzie J, Ragolia L: Vascular smooth muscle cell growth and insulin regulation of mitogen-activated protein kinase in hypertension. Am J Physiol Cell Physiol 1998; 275: C42-C49
4. Berridge MV, Tan AS: Characterization of the cellular reduction of 3-(4, 5-dimethylthiazol-2-yl)-2, 5-diphenyltetrazolium bromide (MTT): subcellular localization, substrate dependence, and involvement of mitochondrial electron transport in MTT reduction. Archives of Biochemistry and Biophysics 1993; 303: 474-482
5. Black JL, Johnson PR: Factors controlling smooth muscle proliferation and airway remodelling. Curr Opin Allergy Clin Immunol 2002; 2: 47-51
6. Cefalu WT: Concept, strategies, and feasibility of noninvasive insulin delivery. Diabetes Care 2004; 27: 239-246
7. Chachami G, Simos G, Hatziefthimiou A, Bonanou S, Molyvdas P-A, Paraskeva E: Cobalt induces hypoxia-inducible factor-1{alpha} expression in airw. Am J Respir Cell Mol Biol 2004; 31: 544-551
8. Cherrington AD, Neal DW, Edgerton DS, Glass D, Bowen L, Hobbs CH, Leach C, Rosskamp R, Strack TR: Inhalation of insulin in dogs: assessment of insulin levels and comparison to subcutaneous injection. Diabetes 2004; 53: 877-881
9. Chiappara G, Gagliardo R, Siena A, Bonsignore MR, Bousquet J, Bonsignore G, Vignola AM: Airway remodelling in the pathogenesis of asthma. Curr Opin Allergy Clin Immunol 2001; 1: 85-93
10. Colthorpe P, Farr SJ, Taylor G, Smith IJ, Wyatt D: The pharmacokinetics of pulmonary-delivered insulin: a comparison of intratracheal and aerosol administration to the rabbit. Pharmaceutical Research 1992; 9: 764-768
11. Cory AH, Owen TC, Barltrop JA, Cory JG: Use of an aqueous soluble tet-razolium/formazan assay for cell growth assays in culture. Cancer Commun 1991; 3: 207-212
12. Gosens R, Nelemans SA, Hiemstra M, Grootte Bromhaar MM, Meurs H, Zaagsma J: Insulin induces a hypercontractile airway smooth muscle phenotype. Eur J Pharmacol 2003; 481: 125-131
13. Halayko AJ, Kartha S, Stelmack GL, McConville J, Tam J, Camoretti-Mercado B, Forsythe SM, Hershenson MB, Solway J: Phophatidylinosi-tol-3 kinase/mammalian target of rapamycin/p 70S6Kregulates contractile protein accumulation in airway myocyte differentiation. Am J Respir Cell Mol Biol 2004; 31: 266-275
14. Halayko AJ, Rector E, Stephens NL: Airway smooth muscle cell proliferation: characterization of subpopulations by sensitivity to heparin inhibition. Am J Physiol Lung Cell Mol Physiol 1998; 274: L17-L25
15. Halayko AJ, Solway J: Plasticity in skeletal, cardiac, and smooth muscle: invited review: molecular mechanisms of phenotypic plasticity in smooth muscle cells. J Appl Physiol 2001; 90: 358-368
16. Hilsted J, Madsbad S, Hvidberg A, Rasmussen MH, Krarup T, Ipsen H, Hansen B, Pedersen M, Djurup R, Oxenboll B: Intranasal insulin therapy: the clinical realities. Diabetologia 1995; 38: 680-684
17. Jendle JH, Karlberg BE: Effects of intrapulmonary insulin in patients with non-insulin-dependent diabetes. Scand J Clin Lab Invest 1996; 56: 555-561
18. Jung F, Haendeler J, Goebel C, Zeiher AM, Dimmeler S: Growth factor-induced phosphoinositide 3-OH kinase/Akt phosphorylation in smooth muscle cells: induction of cell proliferation and inhibition of cell death. Cardiovasc Res 2000; 48: 148-157
19. Karpova AY, Abe MK, Li J, Liu PT, Rhee JM, Kuo WL, Hershenson MB: MEK1 is required for PDGF-induced ERK activation and DNA synthesis in tracheal myocytes. Am J Physiol 1997; 272: L558-L565
20. Kobayashi Y, Naruse K, Hamada Y, Nakashima E, Kato K, Akiyama N, Kamiya H, Watarai A, Nakae M, Oiso Y, Nakamura J: Human proinsulin C-peptide prevents proliferation of rat aortic smooth muscle cells cultured in high-glucose conditions. Diabetologia 2005; 48: 2396-2401
21. Laube B, Benedict G, Dobs A: The lung as an alternative route of delivery for insulin in controlling postprandial glucose levels in patients with diabetes. Chest 1998; 114: 1734-1739
22. Ma X, Wang Y, Stephens NL: Serum deprivation induces a unique hypercontractile phenotype of cultured smooth muscle cells. Am J Physiol Cell Physiol 1998; 274: C1206-C1214
23. Mandal TK: Inhaled insulin for diabetes mellitus. Am J Health Syst Pharm 2005; 62: 1359-1364
24. Noveral JP, Grunstein MM: Tachykinin regulation of airway smooth muscle cell proliferation. Am J Physiol 1995; 269: L339-L343
25. Papayianni M, Gourgoulianis KI, Molyvdas PA: Insulin NO-dependent action on airways smooth muscles. Nitric Oxide 2001; 5: 72-76
26. Rave K, Bott S, Heinemann L, Sha S, Becker RHA, Willavize SA, Heise T: Time-action profile of inhaled insulin in comparison with subcutaneously injected insulin lispro and regular human insulin. Diabetes Care 2005; 28: 1077-1082
27. Saltiel AR, Kahn CR: Insulin signalling and the regulation of glucose and lipid metabolism. Nature 2001; 414: 799-806
28. Skalli O, Ropraz P, Trzeciak A, Benzonana G, Gillessen D, Gabbiani G: A monoclonal antibody against alpha-smooth muscle actin: a new probe for smooth muscle differentiation. J Cell Biol 1986; 103: 2787-2796
29. Wang CC, Gurevich I, Draznin B: Insulin affects vascular smooth muscle cell phenotype and migration via distinct signaling pathways. Diabetes 2003; 52: 2562-2569
30. White MF: Insulin signaling in health and disease. Science 2003; 302: 1710-1711
31. Zhou L, Hershenson MB: Mitogenic signaling pathways in airway smooth muscle. Respiratory Physiology & Neurobiology 2003; 137: 295-308