Effects of high bone turnover on the biomechanical properties of the L3 vertebra in an ovine model of early stage osteoporosis

Spine

Volumn 33, Issue 23, 2008, Pages 2518-2523

  Kennedy, Oran D ^a,b   Brennan, Orlaith ^a,b   Mahony, Nicholas J ^b   Rackard, Susan M ^c   O'Brien, Fergal J ^a,b   Taylor, David ^b   Lee, Clive T ^a,b  

^a ROYAL COLLEGE OF SURGEONS IN IRELAND   (Ireland)

^b TRINITY COLLEGE DUBLIN   (Ireland)

^c UNIVERSITY COLLEGE DUBLIN   (Ireland)

Author keywords

High bone turnover; Lumbar vertebrae; Mechanical properties; Ovariectomy

Indexed keywords

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BIOMECHANICS; BONE MASS; BONE TURNOVER; CONTROLLED STUDY; CORTICAL BONE; FEMALE; LUMBAR VERTEBRA; NONHUMAN; OSTEOPOROSIS; PRIORITY JOURNAL; SHEEP; TRABECULAR BONE; ANIMAL; BONE DENSITY; BONE REMODELING; COMPRESSIVE STRENGTH; DISEASE MODEL; ELASTICITY; METABOLISM; OVARIECTOMY; PATHOLOGY; PATHOPHYSIOLOGY; PHYSIOLOGY;

DIAGNOSTIC AGENT; FLUORESCENT DYE;

ANIMALS; BIOMECHANICS; BONE DENSITY; BONE REMODELING; COMPRESSIVE STRENGTH; DISEASE MODELS, ANIMAL; ELASTICITY; FEMALE; FLUORESCENT DYES; LUMBAR VERTEBRAE; OSTEOPOROSIS; OVARIECTOMY; SHEEP;

EID: 59649120948     PISSN: 03622436     EISSN: 15281159     Source Type: Journal    
DOI: 10.1097/BRS.0b013e318186b292     Document Type: Article

References (33)

1. Cummings SR, Black DM, Nevitt MC, et al. Appendicular bone density and age predict hip fracture in women. The Study of Osteoporotic Fractures Research Group. JAMA 1990;263:665-8.
2. Cooper C, Campion G, Melton LJ III. Hip fractures in the elderly: a worldwide projection. Osteoporos Int 1992;2:285-9.
3. Jacobsen SJ, Cooper C, Gottlieb MS, et al. Hospitalization with vertebral fracture among the aged: a national population-based study, 1986-1989. Epidemiology 1992;3:515-18.
4. Dickerson CR, Saha S, Hotchkiss CE. Relationships between densitometric and morphological parameters as measured by peripheral computed tomography and the compressive behavior of lumbar vertebral bodies from macaques (Macaca fascicularis). Spine 2008;33:366-72.
5. Duboeuf F, Jergas M, Schott AM, et al. A comparison of bone densitometry measurements of the central skeleton in post-menopausal women with and without vertebral fracture. Br J Radiol 1995;68:747-53.
6. Ito M, Ohki M, Hayashi K, et al. Relationship of spinal fracture to bone density, textural, and anthropometric parameters. Calcif Tissue Int 1997;60: 240-4.
7. Lang TF, Guglielmi G, van Kuijk C, et al. Measurement of bone mineral density at the spine and proximal femur by volumetric quantitative computed tomography and dual-energy x-ray absorptiometry in elderly women with and without vertebral fractures. Bone 2002;30:247-50.
8. Legrand E, Chappard D, Pascaretti C, et al. Trabecular bone microarchitecture, bone mineral density, and vertebral fractures in male osteoporosis. J Bone Miner Res 2000;15:13-19.
9. Cefalu CA. Is bone mineral density predictive of fracture risk reduction? Curr Med Res Opin 2004;20:341-9.
10. Parfitt AM. Implications of architecture for the pathogenesis and prevention of vertebral fracture. Bone 1992;13:S41-7.
11. Parfitt AM. High bone turnover is intrinsically harmful: two paths to a similar conclusion. The Parfitt view. J Bone Miner Res 2002;17:1558-9.
12. Delmas PD. How does antiresorptive therapy decrease the risk of fracture in women with osteoporosis? Bone 2000;27:1-3.
13. Greenspan SL, Harris ST, Bone H, et al. Bisphosphonates: safety and efficacy in the treatment and prevention of osteoporosis. Am Fam Physician 2000; 61:2731-6.
14. Parfitt AM. Misconceptions (2): turnover is always higher in cancellous than in cortical bone. Bone 2002;30:807-9.
15. Schorlemmer S, Ignatius A, Claes L, et al. Inhibition of cortical and cancellous bone formation in glucocorticoid-treated OVX sheep. Bone 2005;37: 491-6.
16. Rahn BA. Polychrome fluorescence labelling of bone formation, instrumental aspects and experimental use. Zeiss Information 1977;22:36-9.
17. Lanyon LE, Goodship AE, Pye C, et al. Mechanically adaptive bone remodeling: a quantitative study on functional adaption in the radius following ulna osteotomy in sheep. J Biomech 1982;15:141-54.
18. Lee TC, Staines A, Taylor D. Bone adaptation to load: microdamage as a stimulus for bone remodelling. J Anat 2002;201:437-46.
19. Mohsin S, Taylor D, Lee TC. Three-dimensional reconstruction of Haversian systems in ovine compact bone. Eur J Morphol 2002;40:309-15.
20. Lee TC, Taylor D. Quantification of ovine bone adaptation to altered load: morphometry, density, and surface strain. Eur J Morphol 2003;41:117-25.
21. Mosekilde L, Mosekilde L. Normal vertebral body size and compressive strength: relations to age and to vertebral and iliac trabecular bone compressive strength. Bone 1986;7:207-12.
22. Thomsen JS, Ebbesen EN, Mosekilde L. Static histomorphometry of human iliac crest and vertebral trabecular bone: a comparative study. Bone 2002; 30:267-74.
23. Parfitt AM, Drezner MK, Glorieux FH, et al. Bone histomorphometry: standardization of nomenclature, symbols, and units. Report of the ASBMR Histomorphometry Nomenclature Committee. J Bone Miner Res 1987;2: 595-610.
24. Keaveny TM, Wachtel EF, Kopperdahl DL. Mechanical behavior of human trabecular bone after overloading. J Orthop Res 1999;17:346-53.
25. Kopperdahl DL, Pearlman JL, Keaveny TM. Biomechanical consequences of an isolated overload on the human vertebral body. J Orthop Res 2000;18: 685-90.
26. Ross PD, Davis JW, Epstein RS, et al. Pre-existing fractures and bone mass predict vertebral fracture incidence in women. Ann Intern Med 1991;114: 919-23.
27. Bouxsein ML. Bone quality: where do we go from here? Osteoporos Int 2003;14(suppl 5):118-27.
28. Mitton D, Rumelhart C, Hans D, et al. The effects of density and test conditions on measured compression and shear strength ofcancellous bone from the lumbar vertebrae of ewes. Med Eng Phys 1997;19:464-74.
29. Turner AS, Alvis M, Myers W, et al. Changes in bone mineral density and bone-specific alkaline phosphatase in ovariectomized ewes. Bone 1995;17: 395S-402S.
30. Chavassieux P, Garnero P, Duboeuf F, et al. Effects of a new selective estrogen receptor modulator (MDL 103,323) on cancellous and cortical bone in ovariectomized ewes: a biochemical, histomorphometric, and densitometric study. J Bone Miner Res 2001;16:89-96.
31. Kimmel DB, Jee WS. A quantitative histologic study of bone turnover in young adult beagles. Anat Rec 1982;203:31-45.
32. Lill CA, Fluegel AK, Schneider E. Effect of ovariectomy, malnutrition and glucocorticoid application on bone properties in sheep: a pilot study. Osteoporos Int 2002;13:480-6.
33. Krajcinovic D. Damage Mechanics. New York: Elsevier Science BV; 1996.