Comparison of hydrophilic interaction and reversed-phase liquid chromatography coupled with tandem mass spectrometric detection for the determination of three pharmaceuticals in human plasma

Biomedical Chromatography

Volumn 22, Issue 12, 2008, Pages 1393-1402

  Apostolou, Constantinos ^a   Kousoulos, Constantinos ^a   Dotsikas, Yannis ^a   Loukas, Yannis L ^a  

^a UNIVERSITY OF ATHENS   (Greece)

Author keywords

Direct injection; HILIC; LC MS MS; RPLC; Sample preparation; Silica

Indexed keywords

CHROMATOGRAPHIC ANALYSIS; DIRECT INJECTION; EXTRACTION; HIGH PRESSURE LIQUID CHROMATOGRAPHY; HYDROPHILICITY; MASS SPECTROMETERS; MASS SPECTROMETRY; PHASE SEPARATION; PLASMA (HUMAN);

DONEPEZIL; HUMAN PLASMAS; HYDROPHILIC INTERACTION LIQUID CHROMATOGRAPHIES; LC-MS-MS; LC.MS/MS; LIQUID-LIQUID EXTRACTION; REVERSED PHASE LIQUID-CHROMATOGRAPHY; REVERSED-PHASE LIQUID CHROMATOGRAPHY; SAMPLE PREPARATION; TANDEM MASS SPECTROMETRIC DETECTION;

SILICA;

CETIRIZINE; DONEPEZIL; LORATADINE; INDAN DERIVATIVE; PIPERIDINE DERIVATIVE;

ACCURACY; AQUEOUS SOLUTION; ARTICLE; CONTROLLED STUDY; DRUG BLOOD LEVEL; DRUG DETERMINATION; DRUG RETENTION; HUMAN; HYDROPHILICITY; INTERMETHOD COMPARISON; LIQUID CHROMATOGRAPHY; LIQUID LIQUID EXTRACTION; PRECIPITATION; REVERSED PHASE HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; SENSITIVITY AND SPECIFICITY; SOLID PHASE EXTRACTION; TANDEM MASS SPECTROMETRY; TIME; BLOOD; COMPARATIVE STUDY; METHODOLOGY; REPRODUCIBILITY;

CETIRIZINE; CHROMATOGRAPHY, LIQUID; HUMANS; INDANS; LORATADINE; PIPERIDINES; REPRODUCIBILITY OF RESULTS; TANDEM MASS SPECTROMETRY;

EID: 59649112012     PISSN: 02693879     EISSN: 10990801     Source Type: Journal    
DOI: 10.1002/bmc.1071     Document Type: Article

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