An improved high-throughput liquid chromatographic/tandem mass spectrometric method for terbinafine quantification in human plasma, using automated liquid-liquid extraction based on 96-well format plates

Biomedical Chromatography

Volumn 21, Issue 2, 2007, Pages 201-208

  Dotsikas, Yannis ^a   Apostolou, Constantinos ^a   Kousoulos, Constantinos ^a   Tsatsou, Georgia ^a   Loukas, Yannis L ^a  

^a UNIVERSITY OF ATHENS   (Greece)

Author keywords

96 well format plates; Bioequivalence; Electrospray tandem mass spectrometry; Terbinafine

Indexed keywords

CALIBRATION; ELECTROSPRAY IONIZATION; HIGH PRESSURE LIQUID CHROMATOGRAPHY; MASS SPECTROMETRY; PLASMA (HUMAN); POSITIVE IONS; QUALITY CONTROL; SOLVENT EXTRACTION; THROUGHPUT;

96-WELL FORMAT; 96-WELL FORMAT PLATE; BIOEQUIVALENCE; ELECTROSPRAY TANDEM MASS SPECTROMETRY; HIGH-THROUGHPUT; HUMAN PLASMAS; INTERNAL STANDARDS; LIQUID-LIQUID EXTRACTION; TANDEM MASS SPECTROMETRIC; TERBINAFINE;

ORGANIC SOLVENTS;

HEXANE; METHYLAMINE; ORGANIC SOLVENT; TERBINAFINE; TERT BUTYL METHYL ETHER;

ACCURACY; ANALYTIC METHOD; ARTICLE; AUTOANALYSIS; BIOEQUIVALENCE; CALIBRATION; CENTRIFUGATION; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG BLOOD LEVEL; FREEZING; HIGH THROUGHPUT SCREENING; HUMAN; HUMAN EXPERIMENT; LIQUID LIQUID EXTRACTION; NORMAL HUMAN; POSITIVE ION ELECTROSPRAY; QUALITY CONTROL; RELIABILITY; REVERSED PHASE LIQUID CHROMATOGRAPHY; ROBOTICS; SENSITIVITY AND SPECIFICITY; SUPERNATANT; TABLET FORMULATION; TANDEM MASS SPECTROMETRY;

EID: 33847058759     PISSN: 02693879     EISSN: 10990801     Source Type: Journal    
DOI: 10.1002/bmc.738     Document Type: Article

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