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Volumn 37, Issue 1, 2009, Pages 357-360

Genetic variability and outcome in the critically ill: Avoiding SNP judgments

Author keywords

Bacteremia; Cytokines; Mortality; Sepsis; Signal transduction

Indexed keywords

BLOOD CLOTTING FACTOR 5 LEIDEN; CASPASE RECRUITMENT DOMAIN PROTEIN 15; CASPASE RECRUITMENT DOMAIN PROTEIN 4; CYTOCHROME P450; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERLEUKIN 1BETA; INTERLEUKIN 6; TRANSCRIPTION FACTOR; TUMOR NECROSIS FACTOR ALPHA; WARFARIN;

EID: 59649102304     PISSN: 00903493     EISSN: 15300293     Source Type: Journal    
DOI: 10.1097/CCM.0b013e31819311c0     Document Type: Editorial
Times cited : (2)

References (27)
  • 1
    • 0034919862 scopus 로고    scopus 로고
    • Inflammation, coagulopathy, and the pathogenesis of multiple organ dysfunction syndrome
    • Marshall JC: Inflammation, coagulopathy, and the pathogenesis of multiple organ dysfunction syndrome. Crit Care Med 2001; 29:S99-S106
    • (2001) Crit Care Med , vol.29
    • Marshall, J.C.1
  • 2
    • 29144530137 scopus 로고    scopus 로고
    • Evidence of myocardial hibernation in the septic heart
    • Levy RJ, Piel DA, Acton PD, et al: Evidence of myocardial hibernation in the septic heart. Crit Care Med 2005; 33:2752-2756
    • (2005) Crit Care Med , vol.33 , pp. 2752-2756
    • Levy, R.J.1    Piel, D.A.2    Acton, P.D.3
  • 3
    • 4043128084 scopus 로고    scopus 로고
    • Multiorgan failure is an adaptive, endocrine-mediated, metabolic response to overwhelming systemic inflammation
    • Singer M, De Santis V, Vitale D, et al: Multiorgan failure is an adaptive, endocrine-mediated, metabolic response to overwhelming systemic inflammation. Lancet 2004; 364:545-548
    • (2004) Lancet , vol.364 , pp. 545-548
    • Singer, M.1    De Santis, V.2    Vitale, D.3
  • 4
    • 0029893535 scopus 로고    scopus 로고
    • Uncoupling of biological oscillators: A complementary hypothesis concerning the pathogenesis of multiple organ dysfunction syndrome
    • Godin PJ, Buchman TG: Uncoupling of biological oscillators: A complementary hypothesis concerning the pathogenesis of multiple organ dysfunction syndrome. Crit Care Med 1996; 24:1107-1116
    • (1996) Crit Care Med , vol.24 , pp. 1107-1116
    • Godin, P.J.1    Buchman, T.G.2
  • 5
    • 0028314865 scopus 로고
    • Mutation in blood coagulation factor V associated with resistance to activated protein C
    • Bertina RM, Koeleman BP, Koster T, et al: Mutation in blood coagulation factor V associated with resistance to activated protein C. Nature 1994; 369:64-67
    • (1994) Nature , vol.369 , pp. 64-67
    • Bertina, R.M.1    Koeleman, B.P.2    Koster, T.3
  • 6
    • 0033569516 scopus 로고    scopus 로고
    • Pharmacogenomics: Translating functional genomics into rational therapeutics
    • Evans WE, Relling MV: Pharmacogenomics: Translating functional genomics into rational therapeutics. Science 1999; 286:487-491
    • (1999) Science , vol.286 , pp. 487-491
    • Evans, W.E.1    Relling, M.V.2
  • 7
    • 45949100694 scopus 로고    scopus 로고
    • IL6 gene-wide haplotype is associated with susceptibility to acute lung injury
    • Flores C, Ma SF, Maresso K, et al: IL6 gene-wide haplotype is associated with susceptibility to acute lung injury. Transl Res 2008; 152:11-17
    • (2008) Transl Res , vol.152 , pp. 11-17
    • Flores, C.1    Ma, S.F.2    Maresso, K.3
  • 8
    • 45049085042 scopus 로고    scopus 로고
    • Protein C rs2069912 C allele is associated with increased mortality from severe sepsis in North Americans of East Asian ancestry
    • Russell JA, Wellman H, Walley KR: Protein C rs2069912 C allele is associated with increased mortality from severe sepsis in North Americans of East Asian ancestry. Hum Genet 2008; 123:661-663
    • (2008) Hum Genet , vol.123 , pp. 661-663
    • Russell, J.A.1    Wellman, H.2    Walley, K.R.3
  • 9
    • 42949176212 scopus 로고    scopus 로고
    • Sepsis syndrome and death in trauma patients are associated with variation in the gene encoding tumor necrosis factor
    • Menges T, Konig IR, Hossain H, et al: Sepsis syndrome and death in trauma patients are associated with variation in the gene encoding tumor necrosis factor. Crit Care Med 2008; 36:1456-1462
    • (2008) Crit Care Med , vol.36 , pp. 1456-1462
    • Menges, T.1    Konig, I.R.2    Hossain, H.3
  • 10
    • 33846531198 scopus 로고    scopus 로고
    • Innate immunity SNPs are associated with risk for severe sepsis after burn injury
    • Barber RC, Chang LY, Arnoldo BD, et al: Innate immunity SNPs are associated with risk for severe sepsis after burn injury. Clin Med Res 2006; 4:250-255
    • (2006) Clin Med Res , vol.4 , pp. 250-255
    • Barber, R.C.1    Chang, L.Y.2    Arnoldo, B.D.3
  • 11
    • 33845336158 scopus 로고    scopus 로고
    • Polymorphism of the C-reactive protein gene is associated with mortality in bacteraemia
    • Eklund C, Huttunen R, Syrjanen J, et al: Polymorphism of the C-reactive protein gene is associated with mortality in bacteraemia. Scand J Infect Dis 2006; 38:1069-1073
    • (2006) Scand J Infect Dis , vol.38 , pp. 1069-1073
    • Eklund, C.1    Huttunen, R.2    Syrjanen, J.3
  • 12
    • 33747586761 scopus 로고    scopus 로고
    • Association of polymorphisms of IGF1R and genes in the transforming growth factor-beta/bone morphogenetic protein pathway with bacteremia in sickle cell anemia
    • Adewoye AH, Nolan VG, Ma Q, et al: Association of polymorphisms of IGF1R and genes in the transforming growth factor-beta/bone morphogenetic protein pathway with bacteremia in sickle cell anemia. Clin Infect Dis 2006; l;43:593-598
    • (2006) Clin Infect Dis , vol.50 , Issue.43 , pp. 593-598
    • Adewoye, A.H.1    Nolan, V.G.2    Ma, Q.3
  • 13
    • 33745138167 scopus 로고    scopus 로고
    • Variant IRAK-1 haplotype is associated with increased nuclear factor-kappaB activation and worse outcomes in sepsis
    • Arcaroli J, Silva E, Maloney JP, et al: Variant IRAK-1 haplotype is associated with increased nuclear factor-kappaB activation and worse outcomes in sepsis. Am J Respir Crit Care Med 2006; 15;173:1335-1341
    • (2006) Am J Respir Crit Care Med , vol.15 , Issue.173 , pp. 1335-1341
    • Arcaroli, J.1    Silva, E.2    Maloney, J.P.3
  • 14
    • 24944436195 scopus 로고    scopus 로고
    • Interleukin-10 haplotype associated with increased mortality in critically ill patients with sepsis from pneumonia but not in patients with extrapulmonary sepsis
    • Wattanathum A, Manocha S, Groshaus H, et al: Interleukin-10 haplotype associated with increased mortality in critically ill patients with sepsis from pneumonia but not in patients with extrapulmonary sepsis. Chest 2005; 128:1690-1698
    • (2005) Chest , vol.128 , pp. 1690-1698
    • Wattanathum, A.1    Manocha, S.2    Groshaus, H.3
  • 15
    • 14944375926 scopus 로고    scopus 로고
    • Polymorphisms in CD 14, mannose-binding lectin, and toll-like receptor-2 are associated with increased prevalence of infection in critically ill adults
    • Sutherland AM, Walley KR, Russell JA: Polymorphisms in CD 14, mannose-binding lectin, and toll-like receptor-2 are associated with increased prevalence of infection in critically ill adults. Crit Care Med 2005; 33:638-644
    • (2005) Crit Care Med , vol.33 , pp. 638-644
    • Sutherland, A.M.1    Walley, K.R.2    Russell, J.A.3
  • 16
    • 11844292713 scopus 로고    scopus 로고
    • The association of interleukin 6 haplotype clades with mortality in critically ill adults
    • Sutherland AM, Walley KR, Manocha S, et al: The association of interleukin 6 haplotype clades with mortality in critically ill adults. Arch Intern Med 2005; 10;165:75-82
    • (2005) Arch Intern Med , vol.10 , Issue.165 , pp. 75-82
    • Sutherland, A.M.1    Walley, K.R.2    Manocha, S.3
  • 17
    • 59649127441 scopus 로고    scopus 로고
    • Polymorphisms in innate immunity genes predispose to bacteremia and death in the medical intensive care unit
    • Henckaerts L, Nielsen KR, Steffensen R, et al: Polymorphisms in innate immunity genes predispose to bacteremia and death in the medical intensive care unit. Crit Care Med 2009; 37: 192-201
    • (2009) Crit Care Med , vol.37 , pp. 192-201
    • Henckaerts, L.1    Nielsen, K.R.2    Steffensen, R.3
  • 18
    • 32044465949 scopus 로고    scopus 로고
    • Intensive insulin therapy in the medical ICU
    • Van den Berghe G, Wilmer A, Hermans G, et al: Intensive insulin therapy in the medical ICU. New Engl J Med 2006; 354:449-461
    • (2006) New Engl J Med , vol.354 , pp. 449-461
    • Van den Berghe, G.1    Wilmer, A.2    Hermans, G.3
  • 19
    • 52749085896 scopus 로고    scopus 로고
    • Tolllike receptor 1 polymorphisms affect innate immune responses and outcomes in sepsis
    • Wurfel MM, Gordon AC, Holden TD, et al: Tolllike receptor 1 polymorphisms affect innate immune responses and outcomes in sepsis. Am J Respir Crit Care Med 2008; 178:710-720
    • (2008) Am J Respir Crit Care Med , vol.178 , pp. 710-720
    • Wurfel, M.M.1    Gordon, A.C.2    Holden, T.D.3
  • 20
    • 34548175739 scopus 로고    scopus 로고
    • Genetic variants in the NOD2/CARD15 gene are associated with early mortality in sepsis patients
    • Brenmoehl J, Herfarth H, Glück T, et al: Genetic variants in the NOD2/CARD15 gene are associated with early mortality in sepsis patients. Intensive Care Med 2007; 33: 1541-1548
    • (2007) Intensive Care Med , vol.33 , pp. 1541-1548
    • Brenmoehl, J.1    Herfarth, H.2    Glück, T.3
  • 21
    • 84882559811 scopus 로고    scopus 로고
    • Stuber F, Lehman LE, Schewe JC, et al. Genetics. In: Clinical Critical Care Medicine. Albert RK, Slutsky A, Ranieri M, et al (Eds). Philadephia, Elsevier, 2006, pp 13-19
    • Stuber F, Lehman LE, Schewe JC, et al. Genetics. In: Clinical Critical Care Medicine. Albert RK, Slutsky A, Ranieri M, et al (Eds). Philadephia, Elsevier, 2006, pp 13-19
  • 22
    • 0034278017 scopus 로고    scopus 로고
    • Gender differences in sepsis: Genetically determined?
    • discussion 310-303
    • Schroder J, Kahlke V, Book M, et al: Gender differences in sepsis: Genetically determined? Shock 2000; 14:307-310; discussion 310-303
    • (2000) Shock , vol.14 , pp. 307-310
    • Schroder, J.1    Kahlke, V.2    Book, M.3
  • 23
    • 45349102367 scopus 로고    scopus 로고
    • Plasticity of the systemic inflammatory response to acute infection during critical ill- ness: Development of the riboleukogram
    • McDunn JE, Husain KD, Polpitiya AD, et al: Plasticity of the systemic inflammatory response to acute infection during critical ill- ness: Development of the riboleukogram. PLoS ONE 2008; 3:el564
    • (2008) PLoS ONE , vol.3
    • McDunn, J.E.1    Husain, K.D.2    Polpitiya, A.D.3
  • 24
    • 12244252762 scopus 로고    scopus 로고
    • Extremely high interleukin-6 blood levels and outcome in the critically ill are associated with tumor necrosis factor- and interleukin-1-related gene polymorphisms
    • discussion 242-243
    • Watanabe E, Hirasawa H, Oda S, et al: Extremely high interleukin-6 blood levels and outcome in the critically ill are associated with tumor necrosis factor- and interleukin-1-related gene polymorphisms. Crit Care Med 2005; 33:89-97; discussion 242-243
    • (2005) Crit Care Med , vol.33 , pp. 89-97
    • Watanabe, E.1    Hirasawa, H.2    Oda, S.3
  • 25
    • 0029856112 scopus 로고    scopus 로고
    • Acute-phase gene expression correlates with intrahepatic tumor necrosis factor-alpha abundance but not with plasma tumor necrosis factor concentrations during sepsis/systemic inflam- matory response syndrome in the rat
    • Andrejko KM, Deutschman CS: Acute-phase gene expression correlates with intrahepatic tumor necrosis factor-alpha abundance but not with plasma tumor necrosis factor concentrations during sepsis/systemic inflam- matory response syndrome in the rat. Crit Care Med 1996; 24:1947-1952
    • (1996) Crit Care Med , vol.24 , pp. 1947-1952
    • Andrejko, K.M.1    Deutschman, C.S.2
  • 26
    • 0035104585 scopus 로고    scopus 로고
    • Intrahepatic nuclear factor-kappa B activity and alpha 1-acid glycoprotein transcription do not predict outcome after cecal ligation and puncture in the rat
    • Chen J, Raj N, Kim P, et al: Intrahepatic nuclear factor-kappa B activity and alpha 1-acid glycoprotein transcription do not predict outcome after cecal ligation and puncture in the rat. Crit Care Med 2001; 29: 589-596
    • (2001) Crit Care Med , vol.29 , pp. 589-596
    • Chen, J.1    Raj, N.2    Kim, P.3
  • 27
    • 0032437814 scopus 로고    scopus 로고
    • Intrahepatic STAT-3 activation and acute phase gene expression predict outcome after CLP sepsis in the rat
    • Andrejko KM, Chen J, Deutschman CS: Intrahepatic STAT-3 activation and acute phase gene expression predict outcome after CLP sepsis in the rat. Am J Physiol 1998; 275: G1423-G1429
    • (1998) Am J Physiol , vol.275
    • Andrejko, K.M.1    Chen, J.2    Deutschman, C.S.3


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