Dilinoleoylphosphatidylcholine ameliorates scopolamine-induced impairment of spatial learning and memory by targeting α7 nicotinic ACh receptors

Life Sciences

Volumn 84, Issue 9-10, 2009, Pages 263-266

  Yaguchi, Takahiro ^a   Nagata, Tetsu ^a   Nishizaki, Tomoyuki ^a  

^a HYOGO COLLEGE OF MEDICINE   (Japan)

Author keywords

7 ACh receptor; Dilinoleoylphosphatidylcholine; Hippocampal synaptic transmission; Spatial learning and memory

Indexed keywords

1 PALMITOYL 2 LINOLEOYL SN GLYCERO 3 PHOSPHOCHOLINE; 1 PALMITOYL 2 OLEOYL SN GLYCERO 3 PHOSPHOCHOLINE; BUNGAROTOXIN RECEPTOR; DILINOLEOYLPHOSPHATIDYLCHOLINE; PHOSPHATIDYLCHOLINE; SCOPOLAMINE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; COGNITIVE DEFECT; CONTROLLED STUDY; DRUG TARGETING; EXCITATORY POSTSYNAPTIC POTENTIAL; HIPPOCAMPUS; LEARNING; MALE; MEMORY; NONHUMAN; OOCYTE; PROTEIN EXPRESSION; RAT; SYNAPTIC TRANSMISSION; VOLTAGE CLAMP; XENOPUS;

ANIMALS; CHOLINERGIC ANTAGONISTS; MALE; MAZE LEARNING; MEMORY; OOCYTES; PATCH-CLAMP TECHNIQUES; PHOSPHATIDYLCHOLINES; RATS; RATS, WISTAR; RECEPTORS, NICOTINIC; SCOPOLAMINE; SPATIAL BEHAVIOR; XENOPUS LAEVIS;

RATTUS;

EID: 59649098418     PISSN: 00243205     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.lfs.2008.12.003     Document Type: Article

References (18)

1. Ikeuchi Y., Nishizaki T., Matsuoka T., and Sumikawa K. Long-lasting enhancement of ACh receptor currents by lysophospholipids. Molecular Brain Research 45 2 (1997) 317-320
2. Kanno T., Yamamoto H., Yaguchi T., Hi R., Mukasa T., Fujikawa H., Nagata T., Yamamoto S., Tanaka A., and Nishizaki T. The linoleic acid derivative DCP-LA selectively activates PKC-ε, possibly binding to the phosphatidylserine binding site. Journal of Lipid Research 47 6 (2006) 1146-1156
3. Matsuyama S., Matsumoto A., Enomoto T., and Nishizaki T. Activation of nicotinic acetylcholine receptors induces long-term potentiation in vivo in the intact mouse dentate gyrus. European Journal of Neuroscience 12 10 (2000) 3741-3747
4. Medina J.H., and Izquierdo I. Retrograde messengers, long-term potentiation and memory. Brain Research Review 21 2 (1995) 185-194
5. Miyamoto H., Yaguchi T., Ohta K., Nagai K., Nagata T., Yamamoto S., and Nishizaki T. 2-pyrrolidinone induces a long-lasting facilitation of hippocampal synaptic transmission by enhancing α7 ACh receptor responses via a PKC pathway. Molecular Brain Research 117 1 (2003) 91-96
6. Nagata T., Yamamoto S., Yaguchi T., Iso H., Tanaka A., and Nishizaki T. The newly synthesized linoleic acid derivative DCP-LA ameliorates memory deficits in animal models treated with amyloid-b peptide and scopolamine. Psychogeriatrics 5 4 (2005) 122-126
7. Nishizaki T., and Sumikawa K. Lysophosphatidic acid potentiates ACh receptor currents by G-protein-mediated activation of protein kinase C. Molecular Brain Research 50 1-2 (1997) 121-126
8. Nishizaki T., Ikeuchi Y., Matsuoka T., and Sumikawa K. Short-term depression and long-term enhancement of ACh-gated channel currents induced by linoleic and linolenic acid. Brain Research 751 2 (1997) 253-258
9. Nishizaki T., Matsuoka T., Nomura T., and Sumikawa K. Modulation of ACh receptor currents by arachidonic acid. Molecular Brain Research 57 1 (1998) 173-179
10. Nishizaki T., Nomura T., Matsuoka T., Enikolopov G., and Sumikawa K. Arachidonic acid induces a long-lasting facilitation of hippocampal synaptic transmission by modulating PKC activity and nicotinic ACh receptors. Molecular Brain Research 69 2 (1999) 263-272
11. Nishizaki T., Nomura T., Matsuoka T., and Tsujishita Y. Arachidonic acid as a messenger for the expression of long-term potentiation. Biochemical and Biophysical Research Communications 254 2 (1999) 446-449
12. Nishizaki T., Nomura T., Matuoka T., Kondoh T., Enikolopo G., Sumikawa K., Watabe S., Shiotani T., and Yoshii M. The anti-dementia drug nefiracetam facilitates hippocampal synaptic transmission by functionally targeting presynaptic nicotinic ACh receptors. Molecular Brain Research 80 1 (2000) 53-62
13. Nishizaki T., Nomura T., Matsuyama S., Kondoh T., Fujimoto E., and Yoshii M. Critical role of presynaptic nicotinic ACh receptor in the formation of long-term potentiation: implication of development of anti-dementia drug. Psychogeriatrics 1 3 (2001) 209-217
14. 2 signaling pathway. Life Sciences 68 25 (2001) 2885-2891
15. Tanaka A., and Nishizaki T. The newly synthesized linoleic acid derivative FR236924 induces a long-lasting facilitation of hippocampal neurotransmission by targeting nicotinic acetylcholine receptors. Bioorganic and Medical Chemistry Letters 13 6 (2003) 1037-1040
16. Yaguchi T., Yamamoto S., Nagata T., Kanno T., Tanaka A., and Nishizaki T. Effects of cis-unsaturated free fatty acids on PKC-ε activation and nicotinic ACh receptor responses. Molecular Brain Research 133 2 (2005) 320-324
17. Yaguchi T., Nagata T., Mukasa T., Fujikawa H., Yamamoto H., Yamamoto S., Iso H., Tanaka A., and Nishizaki T. Linoleic acid derivative DCP-LA improves learning impairment in SAMP8. Neuroreport 17 1 (2006) 105-108
18. Yamamoto S., Kanno T., Nagata T., Yaguchi T., Tanaka A., and Nishizaki T. The linoleic acid derivative FR236924 facilitates hippocampal synaptic transmission by enhancing activity of presynaptic α7 acetylcholine receptors on the glutamatergic terminals. Neuroscience 130 1 (2005) 207-213