LC/MS/MS for identification of in vivo and in vitro metabolites of jatrorrhizine

Biomedical Chromatography

Volumn 22, Issue 12, 2008, Pages 1360-1367

  Zhang, Yi ^a   Wu, Wenhua ^a   Han, Fengmei ^a   Chen, Yong ^a  

^a HUBEI UNIVERSITY   (China)

Author keywords

HPLC; Jatrorrhizine; Metabolite; MS; MS MS

Indexed keywords

ALKYLATION; BIOMOLECULES; BODY FLUIDS; HYDROXYLATION; PHASE SEPARATION; PURIFICATION; RATS;

HPLC; IN-VITRO; IN-VIVO; INTESTINAL FLORA; JATRORRHIZINE; LC-MS-MS; LIVER MICROSOMES; MS; MS/MS; RAT URINE;

METABOLITES;

DRUG METABOLITE; JATRORRHIZINE; BERBERINE; DRUG DERIVATIVE;

ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; BLOOD SAMPLING; CHEMICAL REACTION; DRUG IDENTIFICATION; DRUG STRUCTURE; DRUG TRANSFORMATION; FECES ANALYSIS; IN VITRO STUDY; IN VIVO STUDY; INTESTINE FLORA; LIQUID CHROMATOGRAPHY; LIVER MICROSOME; MALE; NONHUMAN; RAT; SOLID PHASE EXTRACTION; TANDEM MASS SPECTROMETRY; URINALYSIS; ANIMAL; BLOOD; CHEMISTRY; FECES; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; METABOLISM; METHODOLOGY; REPRODUCIBILITY; URINE; WISTAR RAT;

RATTUS;

ANIMALS; BERBERINE; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; FECES; MICROSOMES, LIVER; RATS; RATS, WISTAR; REPRODUCIBILITY OF RESULTS; TANDEM MASS SPECTROMETRY;

EID: 59649091584     PISSN: 02693879     EISSN: 10990801     Source Type: Journal    
DOI: 10.1002/bmc.1066     Document Type: Article

References (14)

1. Appolonova SA, Shpak AV and Semenov VA. Liquid chromatography-electrospray ionization ion trap mass spectrometry for analysis of mesocarb and its metabolites in human urine. Journal of chromatography B 2004; 800: 281-289.
2. Bradford MM. A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Analytical Biochemistry 1976;72: 248-254.
3. Chan SA, Chen MJ, Liu TY, Fuh MR, Deng JF, Wu ML and Hsieh SJ. Determination of aristolochic acids in medicinal plant and herbal product by liquid chromatography-electrospray-ion trap mass spectrometry. Talanta 2003; 60: 679-685.
4. Chen HX, Chen Y, Du P and Han FM. LC-MS for identification and elucidation of the structure of in-vivo and in-vitro metabolites of atropine. Chromatographia 2007; 65: 413-418.
5. Chung EW, Ho ENM, Leung DKK, Tang FPW, Yiu KCH and Wan TSM. Detection of anti-ulcer drugs and their metabolites in horse urine by liquid chromatography-mass spectrometry. Chromatographia 2004; 59: S29-38.
6. Fu Y, Hu B, Tang Q, Zhang Q and Xiang J. Effect of jatrorrhizine, berberine, Huanglian decoction and compound-mimic prescription on blood glucose in mice. Chinese Traditional and Herbal Drugs 2005a; 36: 548-551.
7. Fu Y, Hu B, Tang Q, Fu Q and Xiang J. Hypoglycemic activity of jatrorrhizine. Journal of Huazhong University of Science and Technology. Medical Sciences 2005b; 25: 491-493.
8. Han FM, Zhu MM, Chen HX and Chen Y. Liquid chromatography-tandem electrospray ionization ion trap mass spectrometric assay for the metabolites of jatrorrhizine in rat urine. Acta Pharmaceutica Sinica 2006; 41: 846-851.
9. Smyth WF. Electrospray ionisation mass spectrometric behaviour of selected drugs and their metabolites. Analytica Chimica Acta 2003; 492: 1-16.
10. Smyth WF. Recent studies on the electrospray ionisation mass spectrometric behaviour of selected nitrogen-containing drug molecules and its application to drug analysis using liquid chromatography-electrospray ionisation mass spectrometry. Journal of Chromatography B 2005; 824: 1-20.
11. Thevis M, Fubholler G, Geyer H, Rodchenkov G, Mareck U, Sigmund G, Koch A, Thomas A and Schanzer W. Detection of stanozolol and its major metabolites in human urine by liquid chromatography-tandem mass spectrometry. Chromatographia 2006; 64: 441-446.
12. Xing J, Xie CF and Lou HX. Recent applications of liquid chromatography-mass spectrometry in natural products bioanalysis. Journal of Pharmaceutical and Biomedical Analysis 2007; 44: 368-378.
13. Yu Sen, Pang X, Deng Y, Liu L, Liang Y, Liu X, Xie L, Wang G and Wang X. A sensitive and specific liquid chromatography mass spectrometry method for simultaneous determination of berberine, palmatine, coptisine, epiberberine and jatrorrhizine from Coptidis Rhizoma in rat plasma. International Journal of Mass Spectrometry 2007; 268: 30-37.
14. Zuo F, Nakamura N, Akao T and Hattori M. Pharmacokinetics of berberine and its main metabolites in conventional and pseudo germ-free rats determined by liquid chromatography/ion trap mass spectrometry. Drug Metabolism and Disposition 2006; 34: 2064-2072.