Co-localization of inducible nitric oxide synthase and phosphorylated Akt in the lesional skins of patients with melasma

Journal of Dermatology

Volumn 36, Issue 1, 2009, Pages 10-16

  Jo, Ho Youn ^a   Kim, Chun Ki ^a   Suh, In Bum ^a   Ryu, Sook Won ^a   Ha, Kwon Soo ^a   Kwon, Young Geun ^b   Kim, Young Myeong ^a  

^a Kangwon National University   (South Korea)

^b Yonsei University   (South Korea)

Author keywords

Akt; Inducible nitric oxide synthase; Melasma; Skin biopsy

Indexed keywords

IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INDUCIBLE NITRIC OXIDE SYNTHASE; MESSENGER RNA; NITRIC OXIDE; PROTEIN KINASE B;

ADULT; ARTICLE; CELLULAR DISTRIBUTION; CHLOASMA; CLINICAL ARTICLE; CONTROLLED STUDY; ENZYME ACTIVATION; ENZYME PHOSPHORYLATION; EPIDERMIS; FEMALE; HUMAN; HUMAN TISSUE; HYPERPIGMENTATION; IMMUNOHISTOCHEMISTRY; KERATINOCYTE; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SKIN BIOPSY; SKIN DEFECT;

ADULT; BASE SEQUENCE; DNA PRIMERS; FEMALE; HUMANS; MALE; MELANOSIS; MIDDLE AGED; NITRIC OXIDE SYNTHASE TYPE II; PHOSPHORYLATION; PROTO-ONCOGENE PROTEINS C-AKT; RNA, MESSENGER; SKIN;

EID: 59549083214     PISSN: 03852407     EISSN: 13468138     Source Type: Journal    
DOI: 10.1111/j.1346-8138.2008.00579.x     Document Type: Article

References (29)

1. Hearing VJ. Mammalian monophenol monooxygenase (tyrosinase): purification, properties, and reactions catalyzed. Methods Enzymol 1987 142 : 154 165.
2. Pérez-Bernal A, Muñoz-Pérez MA, Camacho F. Management of facial hyperpigmentation. Am J Clin Dermatol 2000 1 : 261 268.
3. Kim YM, Bombeck CA, Billiar TR. Nitric oxide as a bifunctional regulator of apoptosis. Circ Res 1999 84 : 253 256.
4. Moncada S, Palmer RM, Higgs EA. Nitric oxide: physiology, pathophysiology, and pharmacology. Pharmacol Rev 1991 43 : 109 142.
5. Romero-Graillet C, Aberdam E, Clement M et al. Nitric oxide produced by ultraviolet-irradiated keratinocytes stimulates melanogenesis. J Clin Invest 1997 99 : 635 642.
6. Saliou C, Kitazawa M, McLaughlin L et al. Antioxidants modulate acute solar ultraviolet radiation-induced NF-κB activation in a human keratinocyte cell line. Free Radic Biol Med 1999 26 : 174 183.
7. Hattori Y, Hattori S, Kasai K. Lipopolysaccharide activates Akt in vascular smooth muscle cells resulting in induction of inducible nitric oxide synthase through nuclear factor-κB activation. Eur J Pharmacol 2003 481 : 153 158.
8. Kuhn A, Fehsel K, Lehmann P et al. Aberrant timing in epidermal expression of inducible nitric oxide synthase after UV irradiation in cutaneous lupus erythematosus. J Invest Dermatol 1998 111 : 149 153.
9. Tsatmali M, Graham A, Szatkowski D et al. α-melanocyte-stimulating hormone modulates nitric oxide production in melanocytes. J Invest Dermatol 2000 114 : 520 526.
10. Jańczyk A, Garcia-Lopez MA, Fernandez-Peñas P et al. A Polypodium leucotomos extract inhibits solar-simulated radiation-induced TNF-α and iNOS expression, transcriptional activation and apoptosis. Exp Dermatol 2007 16 : 823 829.
11. Rhodes AR, Stern RS, Melski JW. The PUVA lentigo: an analysis of predisposing factors. J Invest Dermatol 1983 81 : 459 463.
12. Costin GE, Hearing VJ. Human skin pigmentation: melanocytes modulate skin color in response to stress. FASEB J 2007 21 : 976 994.
13. Imokawa G, Muyagishi M, Yada Y. Endothelin-1 as a new melanogen: coordinated expression of its gene and the tyrosinase gene in UVB-exposed human epidermis. J Invest Dermatol. 1995 105 : 32 37.
14. Brenner M, Degitz K, Besch R et al. Differential expression of melanoma-associated growth factors in keratinocytes and fibroblasts by ultraviolet A and ultraviolet B radiation. Br J Dermatol 2005 153 : 733 739.
15. Imokawa G, Yad Y, Kimura M et al. Granulocyte/macrophage colony-stimulating factor is an intrinsic keratinocyte-derived growth factor for human melanocytes in UVA-induced melanosis. Biochem J 1996 313 : 625 631.
16. Aberdam E, Bertolotto C, Sviderskaya EV et al. Involvement of microphthalmia in the inhibition of melanocyte lineage differentiation and of melanogenesis by agouti signal protein. J Biol Chem 1998 273 : 19560 19565.
17. Kuzumaki T, Matsuda A, Wakamatsu K et al. Eumelanin biosynthesis is regulated by coordinate expression of tyrosinase and tyrosinase-related protein-1 genes. Exp Cell Res 1993 207 : 33 40.
18. Sasaki M, Horikoshi T, Uchiwa H et al. Up-regulation of tyrosinase gene by nitric oxide in human melanocytes. Pigment Cell Res 2000 13 : 248 252.
19. Shahrad P, Marks R. A pharmacological effect of oestrone on human epidermis. Br J Dermatol 1977 97 : 383 386.
20. Horikoshi T, Nakahara M, Kaminaga H et al. Involvement of nitric oxide in UVB-induced pigmentation in guinea pig skin. Pigment Cell Res 2000 13 : 358 363.
21. Xie QW, Kashiwabara Y, Nathan C. Role of transcription factor NF-κB/Rel in induction of nitric oxide synthase. J Biol Chem 1994 269 : 4705 4708.
22. Taylor BS, de Vera ME, Ganster RW et al. Multiple NF-κB enhancer elements regulate cytokine induction of the human inducible nitric oxide synthase gene. J Biol Chem 1998 273 : 15148 15256.
23. Zhang QS, Maddock DA, Chen JP et al. Cytokine-induced p38 activation feedback regulates the prolonged activation of AKT cell survival pathway initiated by reactive oxygen species in response to UV irradiation in human keratinocytes. Int J Oncol 2001 19 : 1057 1061.
24. Takiwaki H, Shirai S, Kohno H et al. The degrees of UVB-induced erythema and pigmentation correlate linearly and are reduced in a parallel manner by topical anti-inflammatory agents. J Invest Dermatol 1994 103 : 642 646.
25. Ochiai Y, Kaburagi S, Obayashi K et al. A new lipophilic pro-vitamin C, tetra-isopalmitoyl ascorbic acid (VC-IP), prevents UV-induced skin pigmentation through its anti-oxidative properties. J Dermatol Sci 2006 44 : 37 44.
26. Kuwabara Y, Watanabe T, Yasuoka S et al. Topical application of gamma-tocopherol derivative prevents UV-induced skin pigmentation. Biol Pharm Bull 2006 29 : 1175 1179.
27. Shahrad P, Marks R. A pharmacological effect of oestrone on human epidermis. Br J Dermatol 1977 97 : 383 386.
28. Murayama K, Kimura T, Tarutani M et al. Akt activation induces epidermal hyperplasia and proliferation of epidermal progenitors. Oncogene 2007 26 : 4882 4888.
29. Felty Q, Roy D. Mitochondrial signals to nucleus regulate estrogen-induced cell growth. Med Hypotheses 2005 64 : 133 141.