Cause or consequence: What does macrophage apoptosis do in atherosclerosis?

Arteriosclerosis, Thrombosis, and Vascular Biology

Volumn 29, Issue 2, 2009, Pages 153-155

  Clarke, Murray C H ^a   Bennett, Martin R ^a  

^a UNIVERSITY OF CAMBRIDGE   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

INTERLEUKIN 1BETA; INTERLEUKIN 1BETA CONVERTING ENZYME; INTERLEUKIN 6; PROTEIN BCL 2; TUMOR NECROSIS FACTOR ALPHA; APOLIPOPROTEIN E; BCL2 PROTEIN, MOUSE; ONCOPROTEIN;

APOPTOSIS; ATHEROGENESIS; ATHEROSCLEROSIS; ATHEROSCLEROTIC PLAQUE; CELL DIFFERENTIATION; CELL LINEAGE; CYTOKINE PRODUCTION; EDITORIAL; MACROPHAGE; MONOCYTE; NICK END LABELING; NONHUMAN; PHAGOCYTOSIS; PRIORITY JOURNAL; VASCULAR SMOOTH MUSCLE; ANIMAL; ATHEROGENIC DIET; CELL CULTURE; DISEASE MODEL; GENETICS; HUMAN; METABOLISM; MOUSE; MOUSE MUTANT; NECROSIS; NOTE; PATHOLOGY; PERITONEUM MACROPHAGE;

ANIMALS; APOLIPOPROTEINS E; APOPTOSIS; ATHEROSCLEROSIS; CELLS, CULTURED; DIET, ATHEROGENIC; DISEASE MODELS, ANIMAL; HUMANS; MACROPHAGES, PERITONEAL; MICE; MICE, KNOCKOUT; NECROSIS; PROTO-ONCOGENE PROTEINS;

EID: 59449104263     PISSN: 10795642     EISSN: None     Source Type: Journal    
DOI: 10.1161/ATVBAHA.108.179903     Document Type: Editorial

References (15)

1. Geng Y, Libby P. Evidence for apoptosis in advanced human atheroma: colocalization with interleukin-lß converting enzyme. Am J Path. 1995; 147:251-266.
2. Isner J, Keamey M, Bortman S, Passeri J. Apoptosis in human atherosclerosis and restenosis. Circulation. 1995;91:2703-2711.
3. Bennett M, Evan G, Schwartz S. Apoptosis of human vascular smooth muscle cells derived from normal vessels and coronary atherosclerotic plaques. J Clin Invest. 1995;95:2266-2274.
4. Lutgens E, de Muinck ED, Kitslaar PJ, Tordoir JH, Wellens HJ, Daemen MJ. Biphasic pattern of cell turnover characterizes the progression from fatty streaks to ruptured human atherosclerotic plaques. Cardiovasc Res. 1999;41:473-479.
5. Clarke M, Bennett M, Littlewood T. Cell death in the cardiovascular system. Heart. 2007;93:659-664.
6. Clarke MC, Figg N, Maguire JJ, Davenport AP, Goddard M, Littlewood TD, Bennett MR. Apoptosis of vascular smooth muscle cells induces features of plaque vulnerability in atherosclerosis. Nature Medicine. 2006;12:1075-1080.
7. Ait-Oufella H, Kinugawa K, Zoll J, Simon T, Boddaert J, Heeneman S, Blanc-Brude O, Barateau V, Potteaux S, Merval R, Esposito B, Teissier E, Daemen MJ, Leseche G, Boulanger C, Tedgui A, Mallat Z. Lactadherin deficiency leads to apoptotic cell accumulation and accelerated atherosclerosis in mice. Circulation. 2007;115:2168-2177.
8. Clarke MC, Littlewood TD, Figg N, Maguire JJ, Davenport AP, Goddard M, Bennett MR. Chronic apoptosis of vascular smooth muscle cells accelerates atherosclerosis and promotes calcification and medial degeneration. Circ Res. 2008;102:1529-1538.
9. Tabas I. Consequences and therapeutic implications of macrophage apoptosis in atherosclerosis: the importance of lesion stage and phagocytic efficiency. Arterioscler Thromb Vase Biol. 2005;25:2255-2264.
10. Secchiero P, Candido R, Corallini F, Zacchigna S, Toffoli B, Rimondi E, Fabris B, Giacca M, Zauli G. Systemic tumor necrosis factor-related apoptosis-inducing ligand delivery shows antiatherosclerotic activity in apolipoprotein E-null diabetic mice. Circulation. 2006;114:1522-1530.
11. Stoneman V, Braganza D, Figg N, Mercer J, Lang R, Goddard M, Bennett M. Monocyte/macrophage suppression in CD11b diphtheria toxin receptor transgenic mice differentially affects atherogenesis and established plaques. Circ Res. 2007;100:884-893.
12. Thorp E, Cui D, Schrijvers DM, Kuriakose G, Tabas I. Mertk receptor mutation reduces efferocytosis efficiency and promotes apoptotic cell accumulation and plaque necrosis in atherosclerotic lesions of apoe-/-mice. Arterioscler Thromb Vasc Biol. 2008;28:1421-1428.
13. Ait-Oufella H, Pouresmail V, Simon T, Blanc-Brude O, Kinugawa K, Merval R, Offenstadt G, Leseche G, Cohen PL, Tedgui A, Mallat Z. Defective mer receptor tyrosine kinase signaling in bone marrow cells promotes apoptotic cell accumulation and accelerates atherosclerosis. Arterioscler Thromb Vasc Biol. 2008;28:1429-1431.
14. Clausen BE, Burkhardt C, Reith W, Renkawitz R, Forster I. Conditional gene targeting in macrophages and granulocytes using LysMcre mice. Transgenic Res. 1999;8:265-277.
15. Bruey JM, Bruey-Sedano N, Luciano F, Zhai D, Balpai R, Xu C, Kress CL, Bailly-Maitre B, Li X, Osterman A, Matsuzawa S, Terskikh AV, Faustin B, Reed JC. Bcl-2 and Bel-XL regulate proinflammatory caspase-1 activation by interaction with NALP1. Cell. 2007;129:45-56.