Identification of the active site of DS-epimerase 1 and requirement of N-Glycosylation for enzyme function

Journal of Biological Chemistry

Volumn 284, Issue 3, 2009, Pages 1741-1747

  Pacheco, Benny ^a   Maccarana, Marco ^a   Goodlett, David R ^b   Malmström, Anders ^a   Malmström, Lars ^b  

^a LUND UNIVERSITY   (Sweden)

^b UNIVERSITY OF WASHINGTON   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ACTIVE SITES; BIOLOGICAL FUNCTIONS; CATALYTIC RESIDUES; CATALYTIC SITES; CONSERVED RESIDUES; DERMATAN SULFATES; ENZYME FUNCTIONS; GENERAL BASE; GLUCURONIC ACIDS; GLYCOSAMINOGLYCAN; GLYCOSIDIC LINKAGES; N-GLYCOSYLATION; PROTON ABSTRACTIONS; PROTONATED; STRUCTURAL BASIS; SULFATED POLYSACCHARIDES; TERTIARY STRUCTURES;

ABSTRACTING; AMINES; AMINO ACIDS; ENZYME ACTIVITY; ENZYMES; ESTERIFICATION; FUNCTIONS; GLUCOSE; GLYCOSYLATION; ORGANIC ACIDS; POLYSACCHARIDES; PROBABILITY DENSITY FUNCTION; PROTONS; SUGAR (SUCROSE); SUGARS;

DIELECTRIC RELAXATION;

ALANINE; AMINO ACID; C5 PROTON; DERMATAN SULFATE EPIMERASE 1; EPIMERASE; GLUCURONIC ACID; GLYCOSAMINOGLYCAN; HEPARIN LYASE; HEPARINASE II; HEXURONIC ACID; HISTIDINE; IDURONIC ACID; LYASE; PROTON; SUGAR; TYROSINE; UNCLASSIFIED DRUG;

ARTICLE; CATALYSIS; CONTROLLED STUDY; EMBRYO; ENZYME ACTIVE SITE; ENZYME ACTIVITY; ENZYME ANALYSIS; ENZYME CONFORMATION; ENZYME DEGRADATION; ENZYME MECHANISM; EPIMERIZATION; GLYCOSYLATION; HUMAN; HUMAN CELL; MOLECULAR MODEL; MUTATION; PRIORITY JOURNAL; PROTEIN FUNCTION; PROTEIN STRUCTURE; PROTON TRANSPORT; RESIDUE ANALYSIS;

AMINO ACID SUBSTITUTION; ANTIGENS, NEOPLASM; CATALYTIC DOMAIN; CELL LINE; DERMATAN SULFATE; DNA-BINDING PROTEINS; GLYCOSYLATION; HUMANS; MODELS, MOLECULAR; NEOPLASM PROTEINS; PEPTIDE MAPPING; POLYSACCHARIDE-LYASES; PROTEIN STRUCTURE, TERTIARY;

EID: 59449098994     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M805479200     Document Type: Article

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