Combination therapy with histone deacetylase inhibitors and lithium chloride: A novel treatment for carcinoid tumors

Annals of Surgical Oncology

Volumn 16, Issue 2, 2009, Pages 481-486

  Adler, Joel T ^a   Hottinger, Daniel G ^a   Kunnimalaiyaan, Muthusamy ^a   Chen, Herbert ^a  

^a UNIVERSITY OF WISCONSIN SCHOOL OF MEDICINE AND PUBLIC HEALTH   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CHROMOGRANIN A; GLYCOGEN SYNTHASE KINASE 3BETA; HISTONE DEACETYLASE INHIBITOR; LITHIUM CHLORIDE; NOTCH1 RECEPTOR; SUBEROYL BIS HYDROXAMIC ACID; UNCLASSIFIED DRUG; VALPROIC ACID;

ARTICLE; CANCER GROWTH; CANCER INHIBITION; CARCINOID; CELL CYCLE ARREST; CELL PROLIFERATION; CONCENTRATION RESPONSE; CONTROLLED STUDY; DIGESTIVE SYSTEM CANCER; DRUG MECHANISM; ENZYME INHIBITION; HORMONE RELEASE; HUMAN; HUMAN CELL; LUNG CANCER; UPREGULATION; WESTERN BLOTTING;

ADJUVANTS, IMMUNOLOGIC; ANTINEOPLASTIC COMBINED CHEMOTHERAPY PROTOCOLS; BLOTTING, WESTERN; CARCINOID TUMOR; CELL CYCLE; CELL LINE, TUMOR; CELL PROLIFERATION; CHROMOGRANIN A; ENZYME INHIBITORS; GASTROINTESTINAL NEOPLASMS; GLYCOGEN SYNTHASE KINASE 3; HISTONE DEACETYLASES; HUMANS; HYDROXAMIC ACIDS; IMMUNOGLOBULIN J RECOMBINATION SIGNAL SEQUENCE-BINDING PROTEIN; LITHIUM CHLORIDE; LUCIFERASES; LUNG NEOPLASMS; RECEPTOR, NOTCH1; VALPROIC ACID;

EID: 59449093521     PISSN: 10689265     EISSN: 15344681     Source Type: Journal    
DOI: 10.1245/s10434-008-0194-6     Document Type: Article

References (22)

1. IM Modlin KD Lye M Kidd 2003 A 5-decade analysis of 13, 715 carcinoid tumors Cancer 97 934 59
2. A Lal H Chen 2006 Treatment of advanced carcinoid tumors Curr Opin Oncol 18 9 15
3. IM Modlin K Oberg DC Chung 2008 Gastroenteropancreatic neuroendocrine tumours Lancet Oncol 9 61 72
4. T Kadesch 2004 Notch signaling: the demise of elegant simplicity Curr Opin Genet Dev 14 506 12
5. I Maillard WS Pear 2003 Notch and cancer: best to avoid the ups and downs Cancer Cell 3 203 5
6. M Kunnimalaiyaan H Chen 2007 Tumor suppressor role of Notch-1 signaling in neuroendocrine tumors Oncologist 12 535 42
7. M Kunnimalaiyaan K Traeger H Chen 2005 Conservation of the Notch1 signaling pathway in gastrointestinal carcinoid cells Am J Physiol Gastrointest Liver Physiol 289 G636 42
8. M Kunnimalaiyaan AM Vaccaro MA Ndiaye 2006 Overexpression of the NOTCH1 intracellular domain inhibits cell proliferation and alters the neuroendocrine phenotype of medullary thyroid cancer cells J Biol Chem 281 39819 30
9. DY Greenblatt AM Vaccaro R Jaskula-Sztul 2007 Valproic acid activates notch-1 signaling and regulates the neuroendocrine phenotype in carcinoid cancer cells Oncologist 12 942 51
10. DY Greenblatt M Cayo L Ning 2007 Suberoyl bishydroxamic acid inhibits cellular proliferation by inducing cell cycle arrest in carcinoid cancer cells J Gastrointest Surg 11 1515 20
11. M Kunnimalaiyaan AM Vaccaro MA Ndiaye 2007 Inactivation of glycogen synthase kinase-3beta, a downstream target of the raf-1 pathway, is associated with growth suppression in medullary thyroid cancer cells Mol Cancer Ther 6 1151 8
12. A Kappes A Vaccaro M Kunnimalaiyaan 2007 Lithium ions: a novel treatment for pheochromocytomas and paragangliomas Surgery 141 161 5
13. RS Sippel JE Carpenter M Kunnimalaiyaan 2003 Raf-1 activation suppresses neuroendocrine marker and hormone levels in human gastrointestinal carcinoid cells Am J Physiol Gastrointest Liver Physiol 285 G245 54
14. JJ Van Gompel M Kunnimalaiyaan K Holen 2005 ZM336372, a Raf-1 activator, suppresses growth and neuroendocrine hormone levels in carcinoid tumor cells Mol Cancer Ther 4 910 7
15. Adler JT, Hottinger DG, Kunnimalaiyaan M, et al. Histone deacetylase inhibitors upregulate notch1 and inhibit growth in pheochromocytoma cells. Surgery. (in press).
16. L Ning DY Greenblatt M Kunnimalaiyaan 2008 Suberoyl bis-hydroxamic acid activates notch-1 signaling and induces apoptosis in medullary thyroid carcinoma cells Oncologist 13 98 104
17. DY Greenblatt MA Cayo JT Adler 2008 Valproic acid activates Notch1 signaling and induces apoptosis in medullary thyroid cancer cells Ann Surg 247 1036 40
18. CS Platta DY Greenblatt M Kunnimalaiyaan 2008 Valproic acid induces Notch1 signaling in small cell lung cancer cells J Surg Res 148 31 7
19. DO Morgan 1995 Principles of CDK regulation Nature 374 131 4
20. JJ Van Gompel RS Sippel TF Warner 2004 Gastrointestinal carcinoid tumors: factors that predict outcome World J Surg 28 387 92
21. RS Sippel H Chen 2006 Carcinoid tumors Surg Oncol Clin N Am 15 463 78
22. EK Nakakura VR Sriuranpong M Kunnimalaiyaan 2005 Regulation of neuroendocrine differentiation in gastrointestinal carcinoid tumor cells by notch signaling J Clin Endocrinol Metab 90 4350 6