Molecular profiles of progesterone receptor loss in human breast tumors

Breast Cancer Research and Treatment

Volumn 114, Issue 2, 2009, Pages 287-299

  Creighton, Chad J ^a   Kent Osborne, C ^a   Van De Vijver, Marc J ^b,c   Foekens, John A ^d   Klijn, Jan G ^d   Horlings, Hugo M ^b   Nuyten, Dimitry ^b   Wang, Yixin ^e   Zhang, Yi ^e   Chamness, Gary C ^a   Hilsenbeck, Susan G ^a   Lee, Adrian V ^a   Schiff, Rachel ^a  

^a BAYLOR COLLEGE OF MEDICINE   (United States)

^b NETHERLANDS CANCER INSTITUTE   (Netherlands)

^c ACADEMIC MEDICAL CENTER   (Netherlands)

^d JOSEPHINE NEFKENS INSTITUTE   (Netherlands)

^e JOHNSON AND JOHNSON   (United States)

Author keywords

Breast cancer; ER+ PR ; Estrogen receptor; Gene expression profiling; Meta analysis; Progesterone receptor

Indexed keywords

DNA; ESTROGEN RECEPTOR; PROGESTERONE RECEPTOR; RNA; TAMOXIFEN;

ARTICLE; BREAST CANCER; CANCER CHEMOTHERAPY; CONTROLLED STUDY; DNA DETERMINATION; GENE EXPRESSION; GENE EXPRESSION PROFILING; HUMAN; PRIORITY JOURNAL; RNA ANALYSIS; TRANSCRIPTION REGULATION;

1-PHOSPHATIDYLINOSITOL 3-KINASE; BREAST NEOPLASMS; ESTROGEN RECEPTOR ALPHA; FEMALE; GENE DOSAGE; GENE EXPRESSION PROFILING; HUMANS; OLIGONUCLEOTIDE ARRAY SEQUENCE ANALYSIS; PROGNOSIS; PROTEIN KINASES; PROTO-ONCOGENE PROTEINS C-AKT; RECEPTORS, PROGESTERONE; SIGNAL TRANSDUCTION; TUMOR MARKERS, BIOLOGICAL;

EID: 59449087284     PISSN: 01676806     EISSN: 15737217     Source Type: Journal    
DOI: 10.1007/s10549-008-0017-2     Document Type: Article

References (46)

1. Elledge RM, Fuqua SA (2000) Estrogen and progesterone receptors. In: Harris J, Lippman ME, Morrow M, Osborne C (eds) Diseases of the Breast. Lippincott, Williams and Wilkins, Philadelphia, pp 471-488
2. X Cui R Schiff G Arpino CK Osborne AV Lee 2005 Biology of progesterone receptor loss in breast cancer and its implications for endocrine therapy J Clin Oncol 23 30 7721 7735
3. C Osborne 1998 Steroid hormone receptors in breast cancer management Breast Cancer Res Treat 51 3 227 238
4. DC Allred P Brown D Medina 2004 The origins of estrogen receptor alpha-positive and estrogen receptor alpha-negative human breast cancer Breast Cancer Res 6 240 245
5. AJ Poole Y Li Y Kim S-CJ Lin W-H Lee EYHP Lee 2006 Prevention of Brca1-mediated mammary tumorigenesis in mice by a progesterone antagonist Science 314 5804 1467 1470
6. W McGuire 1978 Hormone receptors: their role in predicting prognosis and response to endocrine therapy Semin Oncol 5 4 428 433
7. K Horwitz W McGuire 1978 Estrogen control of progesterone receptor in human breast cancer. Correlation with nuclear processing of estrogen receptor J Biol Chem 253 7 2223 2228
8. K Horwitz Y Koseki W McGuire 1978 Estrogen control of progesterone receptor in human breast cancer: role of estradiol and antiestrogen Endocrinology 103 5 1742 1751
9. V-J Bardou G Arpino RM Elledge CK Osborne GM Clark 2003 Progesterone receptor status significantly improves outcome prediction over estrogen receptor status alone for adjuvant endocrine therapy in two large breast cancer databases J Clin Oncol 21 10 1973 1979
10. CK Osborne 1998 Tamoxifen in the treatment of breast cancer N Engl J Med 339 22 1609 1618
11. M Stendahl L Ryden B Nordenskjold PE Jonsson G Landberg K Jirstrom 2006 High progesterone receptor expression correlates to the effect of adjuvant tamoxifen in premenopausal breast cancer patients Clin Cancer Res 12 15 4614 4618
12. G Arpino H Weiss AV Lee R Schiff S De Placido CK Osborne RM Elledge 2005 Estrogen receptor-positive, progesterone receptor-negative breast cancer: association with growth factor receptor expression and tamoxifen resistance J Natl Cancer Inst 97 17 1254 1261
13. S Tovey B Dunne CJ Witton A Forsyth TG Cooke JMS Bartlett 2005 Can molecular markers predict when to implement treatment with aromatase inhibitors in invasive breast cancer? Clin Cancer Res 11 13 4835 4842
14. PM Ravdin S Green TM Dorr WL McGuire C Fabian RP Pugh RD Carter SE Rivkin JR Borst RJ Belt 1992 Prognostic significance of progesterone receptor levels in estrogen receptor-positive patients with metastatic breast cancer treated with tamoxifen: results of a prospective Southwest Oncology Group study J Clin Oncol 10 8 1284 1291
15. CK Osborne MG Yochmowitz WA Knight WL McGuire 1980 The value of estrogen and progesterone receptors in the treatment of breast cancer Cancer 46 12 Suppl 2884 2888
16. M Dowsett C Allred J Knox E Quinn J Salter C Wale J Cuzick J Houghton N Williams E Mallon 2008 Relationship between quantitative estrogen and progesterone receptor expression and human epidermal growth factor receptor 2 (HER-2) status with recurrence in the arimidex, tamoxifen, alone or in combination trial J Clin Oncol 26 7 1059 1065
17. G Viale M Regan E Maiorano M Mastropasqua P Dell'Orto B Rasmussen J Raffoul P Neven Z Orosz S Braye 2007 Prognostic and predictive value of centrally reviewed expression of estrogen and progesterone receptors in a randomized trial comparing letrozole and tamoxifen adjuvant therapy for postmenopausal early breast cancer: BIG 1-98 J Clin Oncol 25 25 3846 3852
18. Early Breast Cancer Trialists' Collaborative Group 1992 Systemic treatment of early breast cancer by hormonal, cytotoxic, or immune therapy. 133 randomised trials involving 31, 000 recurrences and 24, 000 deaths among 75, 000 women Lancet 339 8785 71 85
19. RL Balleine MJ Earl ML Greenberg CL Clarke 1999 Absence of progesterone receptor associated with secondary breast cancer in postmenopausal women Br J Cancer 79 9-10 1564 1571
20. AM Bamberger K Milde-Langosch HM Schulte T Loning 2000 Progesterone receptor isoforms, PR-B and PR-A, in breast cancer: correlations with clinicopathologic tumor parameters and expression of AP-1 factors Horm Res 54 1 32 37
21. M Dowsett C Harper-Wynne I Boeddinghaus J Salter M Hills M Dixon S Ebbs G Gui N Sacks I Smith 2001 HER-2 amplification impedes the antiproliferative effects of hormone therapy in estrogen receptor-positive primary breast cancer Cancer Res 61 23 8452 8458
22. X Cui P Zhang W Deng S Oesterreich Y Lu GB Mills AV Lee 2003 Insulin-like growth factor-I inhibits progesterone receptor expression in breast cancer cells via the phosphatidylinositol 3-kinase/Akt/mammalian target of rapamycin pathway: progesterone receptor as a potential indicator of growth factor activity in breast cancer Mol Endocrinol 17 4 575 588
23. RG Lapidus SJ Nass NE Davidson 1998 The loss of estrogen and progesterone receptor gene expression in human breast cancer J Mammary Gland Biol Neoplasia 3 85 94
24. T Sorlie CM Perou R Tibshirani T Aas S Geisler H Johnsen T Hastie MB Eisen M van de Rijn SS Jeffrey 2001 Gene expression patterns of breast carcinomas distinguish tumor subclasses with clinical implications Proc Natl Acad Sci USA 98 19 10869 10874
25. T Sorlie R Tibshirani J Parker T Hastie JS Marron A Nobel S Deng H Johnsen R Pesich S Geisler 2003 Repeated observation of breast tumor subtypes in independent gene expression data sets Proc Natl Acad Sci USA 100 14 8418 8423
26. K Chin S DeVries J Fridlyand PT Spellman R Roydasgupta W-L Kuo A Lapuk RM Neve Z Qian T Ryder 2006 Genomic and transcriptional aberrations linked to breast cancer pathophysiologies Cancer Cell 10 6 529 541
27. RM Neve K Chin J Fridlyand J Yeh FL Baehner T Fevr L Clark N Bayani J-P Coppe F Tong 2006 A collection of breast cancer cell lines for the study of functionally distinct cancer subtypes Cancer Cell 10 6 515 527
28. MJ van de Vijver YD He LJ van't Veer H Dai AA Hart DW Voskuil GJ Schreiber JL Peterse C Roberts MJ Marton 2002 A gene-expression signature as a predictor of survival in breast cancer N Engl J Med 347 1999 2009
29. LJ van't Veer H Dai MJ van de Vijver YD He AA Hart M Mao HL Peterse K van der Kooy MJ Marton AT Witteveen 2002 Gene expression profiling predicts clinical outcome of breast cancer Nature 415 530 536
30. Y Wang JG Klijn Y Zhang AM Sieuwerts MP Look F Yang D Talantov M Timmermans ME Meijer-van Gelder J Yu 2005 Gene-expression profiles to predict distant metastasis of lymph-node-negative primary breast cancer Lancet 365 671 679
31. A Potti HK Dressman A Bild RF Riedel G Chan R Sayer J Cragun H Cottrill MJ Kelley R Petersen 2006 Genomic signatures to guide the use of chemotherapeutics Nat Med 12 11 1294 1300
32. AH Bild G Yao JT Chang Q Wang A Potti D Chasse M-B Joshi D Harpole JM Lancaster A Berchuck 2006 Oncogenic pathway signatures in human cancers as a guide to targeted therapies Nature 439 7074 353 357
33. X-J Ma Z Wang PD Ryan SJ Isakoff A Barmettler A Fuller B Muir G Mohapatra R Salunga JT Tuggle 2004 A two-gene expression ratio predicts clinical outcome in breast cancer patients treated with tamoxifen Cancer Cell 5 6 607 616
34. JC Chang EC Wooten A Tsimelzon SG Hilsenbeck MC Gutierrez R Elledge S Mohsin CK Osborne GC Chamness DC Allred 2003 Gene expression profiling for the prediction of therapeutic response to docetaxel in patients with breast cancer Lancet 362 9381 362 369
35. LD Miller J Smeds J George VB Vega L Vergara A Ploner Y Pawitan P Hall S Klaar ET Liu 2005 An expression signature for p53 status in human breast cancer predicts mutation status, transcriptional effects, and patient survival Proc Natl Acad Sci USA 102 38 13550 13555
36. Hoadley K, Weigman V, Fan C, Sawyer L, He X, Troester M, Sartor C, Rieger-House T, Bernard P, Carey L et al (2007) EGFR associated expression profiles vary with breast tumor subtype. BMC Genomics 8(258)
37. S Loi B Haibe-Kains C Desmedt F Lallemand AM Tutt C Gillet P Ellis A Harris J Bergh JA Foekens 2007 Definition of clinically distinct molecular subtypes in estrogen receptor-positive breast carcinomas through genomic grade J Clin Oncol 25 10 1239 1246
38. MB Eisen PT Spellman PO Brown D Botstein 1998 Cluster analysis and display of genome-wide expression patterns Proc Natl Acad Sci USA 95 14863 14868
39. AJ Saldanha 2004 Java Treeview-extensible visualization of microarray data Bioinformatics 20 3246 3248
40. Herschkowitz J, Simin K, Weigman V, Mikaelian I, Usary J, Hu Z, Rasmussen K, Jones L, Assefnia S, Chandrasekharan S et al (2007) Identification of conserved gene expression features between murine mammary carcinoma models and human breast tumors. Genome Biol R76.16
41. C Sotiriou S-Y Neo LM McShane EL Korn PM Long A Jazaeri P Martiat SB Fox AL Harris ET Liu 2003 Breast cancer classification and prognosis based on gene expression profiles from a population-based study Proc Natl Acad Sci USA 100 18 10393 10398
42. J Lamb ED Crawford D Peck JW Modell IC Blat MJ Wrobel J Lerner J-P Brunet A Subramanian KN Ross 2006 The Connectivity Map: using gene-expression signatures to connect small molecules, genes, and disease Science 313 5795 1929 1935
43. S Paik S Shak G Tang C Kim J Baker M Cronin FL Baehner DW Walker MG T Park 2004 A multigene assay to predict recurrence of tamoxifen-treated, node-negative breast cancer N Engl J Med 351 27 2817 2826
44. CM Perou T Sorlie MB Eisen M van de Rijn SS Jeffrey CA Rees JR Pollack DT Ross H Johnsen LA Akslen 2000 Molecular portraits of human breast tumours Nature 406 6797 747 752
45. GE Gross GM Clark GC Chamness WL McGuire 1984 Multiple progesterone receptor assays in human breast cancer Cancer Res 44 2 836 840
46. U Lehmann H Kreipe 2001 Real-Time PCR analysis of DNA and RNA extracted from formalin-fixed and paraffin-embedded biopsies Methods 25 4 409 418