Mucus is a predictor of better prognosis and survival in patients with intraductal papillary mucinous tumor of the pancreas

Journal of Gastrointestinal Surgery

Volumn 7, Issue 1, 2003, Pages 12-19

  Kitagawa, Yuichi ^a   Unger, Trisha A ^a   Taylor, Shari ^b   Kozarek, Richard A ^a   Traverso, L William ^a   Pitt, H A ^c   Warshaw, A L ^c   Wait, B ^c   Hoffman, J P ^c   Prinz, R A ^c  

^a VIRGINIA MASON MEDICAL CENTER   (United States)

^b UNIVERSITY OF WASHINGTON   (United States)

^c C6 GSURG ^*

Author keywords

Intraductal papillary mucinous tumor; Mucus; p53 overexpression; Pancreatic resection

Indexed keywords

CA 19-9 ANTIGEN; PROTEIN P53;

ADULT; AGED; ALCOHOL ABUSE; ARTICLE; CANCER SURGERY; CANCER SURVIVAL; CARCINOMA IN SITU; CONTROLLED STUDY; DATA ANALYSIS; ENDOSCOPY; FEMALE; FOLLOW UP; HUMAN; INTRADUCTAL PAPILLARY MUCINOUS TUMOR; INVASIVE CARCINOMA; JAUNDICE; LIVER FUNCTION; MAJOR CLINICAL STUDY; MALE; MALIGNANT NEOPLASTIC DISEASE; MEDICAL RECORD; MULTIVARIATE ANALYSIS; PANCREAS TUMOR; PROGNOSIS; PROTEIN EXPRESSION; RISK ASSESSMENT; STOMACH MUCUS; ADENOMA; CHEMISTRY; COLLOID CARCINOMA; LIVER; MIDDLE AGED; MORTALITY; MUCUS; PANCREAS CARCINOMA; PATHOPHYSIOLOGY; RISK; RISK FACTOR; SECRETION;

ADENOCARCINOMA, MUCINOUS; ADENOMA; AGED; CA-19-9 ANTIGEN; CARCINOMA, PANCREATIC DUCTAL; FEMALE; FOLLOW-UP STUDIES; HUMANS; LIVER; MALE; MIDDLE AGED; MUCUS; MULTIVARIATE ANALYSIS; ODDS RATIO; PROGNOSIS; RISK FACTORS; TUMOR SUPPRESSOR PROTEIN P53;

EID: 0037703747     PISSN: 1091255X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1091-255X(02)00152-X     Document Type: Article

References (26)

1. Kloppel G.H., Solcia E., Longnecker D.S., Capella C., Sobin L.H. Histological Classification of Tumours of the Exocrine Pancreas. 1996;Springer, New York.
2. Itoh S., Ishiguchi T., Ishigaki T.et al. Mucin-producing pancreatic tumor. CT findings and histopathological correlation Radiology. 183:1992;81-86.
3. Furukawa Y., Fujiyoshi F., Sasaki M.et al. Intraductal papillary mucinous tumors of the pancreas. thin-section helical CT findings AJR. 174:2000;441-447.
4. Cellier C., Uillerier E., Palazzo L.et al. Intraductal papillary mucinous tumors of the pancreas. Accuracy of preoperative computed tomography, endoscopic retrograde pancreatography and endoscopic ultrasonography, and long-term outcome in a large surgical series Gastrointest Endosc. 47:1998;42-49.
5. Furukawa Y., Fujiyoshi F., Sasaki M.et al. HASTE MR cholangiopancreatography in the evaluation of intraductal papillary mucinous tumors of the pancreas. J Comput Assist Tomogr. 23:1999;301-305.
6. Irei H., Honda H., Aibe H.et al. MR cholangiopancreatographic differentiation of benign and malignant intraductal mucin-producing tumor of the pancreas. AJR. 174:2000;1403-1408.
7. Maguchi H. Clinicopathological and diagnostic study of mucin producing pancreatic tumors. Jpn J Gastroenterol. 91:1994;1005-1015.
8. Taki T., Goto H., Naitoh Y.et al. Diagnosis of mucin-producing tumor of the pancreas with an intraductal ultrasonographic system. J Ultrasound Med. 16:1997;1-6.
9. Nakamura Y., Nakazawa S., Yamao K.et al. Evaluation of intraductal ultrasonography of pancreas for intraductal papillary tumor. Gastroenterol Endosc. 39:1997;42-51. [in Japanese with English abstract].
10. Traverso L.W., Peralta A.E., Ryan A.J., Kozarek A.R. Intraductal neoplasms of the pancreas. Am J Surg. 175:1998;426-432.
11. Kaserer K., Schmaus J., Bethge U.et al. Staining patterns of p53 immunohistochemistry and their biological significance in colorectal cancer. J Pathol. 190:2000;450-456.
12. Obara T., Maguchi H., Saitoh Y.et al. Mucin-producing tumor of the pancreas. Surgery or follow-up? Nippon Jpn J Gastroenterol. 91:1994;66-74. [in Japanese with English abstract].
13. Loftus E.V. Jr., Olivares-Pakzad B.A., Batts K.P.et al. Intraductal papillary mucinous tumors of the pancreas. Clinicopathologic features, outcome and nomenclature. Member of the Pancreas Clinic, and Pancreas Surgeons of Mayo Clinic Gastroenterology. 110:1996;1909-1918.
14. Nagai E., Ueki T., Chijiiwa K.et al. Intraductal papillary mucinous neoplasms of the pancreas associated with so-called "mucinous ductal ectasia." Am J Surg Pathol. 19:1995;576-589.
15. Shry Y.M., Su C.H., Tsay S.H., Lui W.Y. Mucin-producing neoplasms of the pancreas. Intraductal papillary mucinous cystic neoplasms. Ann Surg. 223:1996;141-146.
16. Kench J.G., Eckstein R.P., Smith R.C. Intraductal papillary-mucinous neoplasms of the pancreas. A report of five cases with immunohistochemical findings Pathology. 29:1997;7-11.
17. Paal E., Thompson L.D., Pryzygodzki R.M.et al. A clinicopathological and immunohistochemical study of 22 intraductal papillary mucinous neoplasms of the pancreas, with a review of the literature. Mod Pathol. 12:1999;518-528.
18. Satoh K., Shimosegawa T., Morizumi S.et al. K-ras mutation and p53 protein accumulate in intraductal mucin-hypersecreting neoplasms of the pancreas. Pancreas. 12:1996;362-368.
19. Z'graggen K., Rivera J., Compton C.et al. Prevalence of activating K-ras mutation in the evolution stages of neoplasia in intraductal papillary mucinous tumors of the pancreas. Ann Surg. 226:1997;491-498.
20. Satoh K., Sasano H., Shimosegawa T.et al. An immunohistochemical study of the c-erbB-2 oncogene product in intraductal mucin-hypersecreting neoplasms and in ductal cell carcinomas of the pancreas. Cancer. 72:1993;51-56.
21. Sessa F., Solcia E., Capella C.et al. Intraductal papillary- mucinous tumours represent a distinct group of pancreatic neoplasms. An investigation of tumour cell differentiation and K-ras, p53, and c-erbB-2 abnormalities in 26 patients Virchows Arch. 425:1994;357-367.
22. Terada T., Ohta T., Nakanuma Y. Expression of oncogene products, anti-oncogene products and oncofetal antigens in intraductal papillary-mucinous neoplasm of the pancreas. Histopathology. 29:1996;355-361.
23. Mukawa K., Kawa S., Aoki Y.et al. Reduced expression of p53 and cyclin A in intraductal mucin-hypersecreting neoplasm of the pancreas compared with usual pancreatic ductal adenocarcinoma. Am J Gastroenterol. 94:1999;2263-2267.
24. De Ronde T., Deprez P., Van Beers B.et al. Intraductal papillary-mucinous tumours of the pancreas. Clinical and radiological aspects. Acta Gastroenterol Belg. 59:1996;208-210.
25. Madura J.A., Weibke E.A., Howard T.J.et al. Mucin-hypersecreting neoplasms of the pancreas. A precursor to cystic pancreatic malignancies Surgery. 122:1997;786-793.
26. Seo D.W., Kim M.H., Lee S.K.et al. The value of pancreatoscopy in patients with mucinous ductal ectasia. Endoscopy. 29:1997;315-318.