Infertile women with isolated polycystic ovaries are deficient in endometrial expression of osteopontin but not αvβ3 integrin during the implantation window

Fertility and Sterility

Volumn 91, Issue 2, 2009, Pages 489-499

  DuQuesnay, Renée ^a   Wright, Corrina ^a   Aziz, Anita Abdul ^a   Stamp, Gordon W H ^a   Trew, Geoffrey H ^a   Margara, Raul A ^a   White, John O ^b  

^a HAMMERSMITH HOSPITAL   (United Kingdom)

^b SWANSEA UNIVERSITY   (United Kingdom)

Author keywords

Endometrium; implantation; Integrin v 3; isolated PCO morphology; osteopontin

Indexed keywords

ALPHA5 INTEGRIN; ANDROGEN; ANDROGEN RECEPTOR; BETA3 INTEGRIN; ESTRADIOL; ESTROGEN; ESTROGEN RECEPTOR ALPHA; ESTROGEN RECEPTOR BETA; LUTEINIZING HORMONE; MESSENGER RNA; METRIBOLONE; OSTEOPONTIN; PROGESTERONE; PROGESTERONE RECEPTOR;

ADULT; ARTICLE; CELL ADHESION; CELL INTERACTION; CLINICAL ARTICLE; CONTROLLED STUDY; ENDOMETRIAL DISEASE; ENDOMETRIUM; ENDOMETRIUM CELL; FEMALE; FEMALE INFERTILITY; FERTILIZATION IN VITRO; GENE EXPRESSION REGULATION; HISTOLOGY; HUMAN; HUMAN CELL; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; IN VITRO STUDY; MENSTRUAL CYCLE; MORPHOLOGY; NIDATION; OVARY POLYCYSTIC DISEASE; PRIORITY JOURNAL; PROSPECTIVE STUDY; PROTEIN EXPRESSION; PROTEIN SECRETION; QUANTITATIVE ANALYSIS; REAL TIME POLYMERASE CHAIN REACTION; UNIVERSITY HOSPITAL; UPREGULATION;

ADULT; CELL LINE; DOWN-REGULATION; EMBRYO IMPLANTATION; ENDOMETRIUM; ESTRADIOL; FEMALE; HUMANS; IMMUNOHISTOCHEMISTRY; INFERTILITY, FEMALE; INTEGRIN ALPHAVBETA3; MALE; METRIBOLONE; OSTEOPONTIN; POLYCYSTIC OVARY SYNDROME; PROGESTERONE; PROSPECTIVE STUDIES; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER; TESTOSTERONE CONGENERS; TIME FACTORS;

EID: 59249087902     PISSN: 00150282     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.fertnstert.2007.11.063     Document Type: Article

References (55)

1. Yaron Y., Botchan A., Amit A., Kogosowski A., Yovel I., and Lessing J.B. Endometrial receptivity: the age-related decline in pregnancy rates and the effect of ovarian function. Fertil Steril 60 (1993) 314-318
2. Hertig A.T., Rock J., Adams E.C., and Menkin M.C. Thirty-four fertilized human ova, good, bad and indifferent, recovered from 210 women of known fertility; a study of biologic wastage in early human pregnancy. Pediatrics 23 (1959) 202-211
3. Navot D., Scott R.T., Droesch K., Veeck L.L., Liu H.C., and Rosenwaks Z. The window of embryo transfer and the efficiency of human conception in vitro. Fertil Steril 55 (1991) 114-118
4. Lessey B.A. The use of integrins for the assessment of uterine receptivity. Fertil Steril 61 (1994) 812-814
5. Lessey B.A., Damjanovich L., Coutifaris C., Castelbaum A., Albelda S.M., and Buck C.A. Integrin adhesion molecules in the human endometrium. Correlation with the normal and abnormal menstrual cycle. J Clin Invest 90 (1992) 188-195
6. Tabibzadeh S. Patterns of expression of integrin molecules in human endometrium throughout the menstrual cycle. Hum Reprod 7 (1992) 876-882
7. Carson D.D., Lagow E., Thathiah A., Al-Shami R., Farach-Carson M.C., Vernon M., et al. Changes in gene expression during the early to mid-luteal (receptive phase) transition in human endometrium detected by high-density microarray screening. Mol Hum Reprod 8 (2002) 871-879
8. Kao L.C., Tulac S., Lobo S., Imani B., Yang J.P., Germeyer A., et al. Global gene profiling in human endometrium during the window of implantation. Endocrinology 143 (2002) 2119-2138
9. Riesewijk A., Martin J., van Os R., Horcajadas J.A., Polman J., Pellicer A., et al. Gene expression profiling of human endometrial receptivity on days LH+2 versus LH+7 by microarray technology. Mol Hum Reprod 9 (2003) 253-264
10. Apparao K.B., Murray M.J., Fritz M.A., Meyer W.R., Chambers A.F., Truong P.R., et al. Osteopontin and its receptor alphavbeta(3) integrin are coexpressed in the human endometrium during the menstrual cycle but regulated differentially. J Clin Endocrinol Metab 86 (2001) 4991-5000
11. Lessey B.A., and Castelbaum A.J. Integrins in the endometrium of women with endometriosis. Br J Obstet Gynaecol 102 (1995) 347-348
12. Gonzalez R.R., Palomino A., Boric A., Vega M., and Devoto L. A quantitative evaluation of alpha1, alpha4, alphaV and beta3 endometrial integrins of fertile and unexplained infertile women during the menstrual cycle. A flow cytometric appraisal. Hum Reprod 14 (1999) 2485-2492
13. Lessey B.A., Castelbaum A.J., Sawin S.W., Buck C.A., Schinnar R., Bilker W., et al. Aberrant integrin expression in the endometrium of women with endometriosis. J Clin Endocrinol Metab 79 (1994) 643-649
14. Illera M.J., Lorenzo P.L., Gui Y.T., Beyler S.A., Apparao K.B., and Lessey B.A. A role for alphavbeta3 integrin during implantation in the rabbit model. Biol Reprod 68 (2003) 766-771
15. Illera M.J., Cullinan E., Gui Y., Yuan L., Beyler S.A., and Lessey B.A. Blockade of the alpha(v)beta(3) integrin adversely affects implantation in the mouse. Biol Reprod 62 (2000) 1285-1290
16. Johnson G.A., Burghardt R.C., Bazer F.W., and Spencer T.E. Osteopontin: roles in implantation and placentation. Biol Reprod 69 (2003) 1458-1471
17. Christensen B., Nielsen M.S., Haselmann K.F., Petersen T.E., and Sorensen E.S. Post-translationally modified residues of native human osteopontin are located in clusters: identification of 36 phosphorylation and five O-glycosylation sites and their biological implications. Biochem J 390 (2005) 285-292
18. Aplin J.D. Adhesion molecules in implantation. Rev Reprod 2 (1997) 84-93
19. von Wolff M., Strowitzki T., Becker V., Zepf C., Tabibzadeh S., and Thaler C.J. Endometrial osteopontin, a ligand of beta3-integrin, is maximally expressed around the time of the "implantation window.". Fertil Steril 76 (2001) 775-781
20. Franzen A., and Heinegard D. Isolation and characterization of two sialoproteins present only in bone calcified matrix. Biochem J 232 (1985) 715-724
21. Senger D.R., Perruzzi C.A., Papadopoulos A., and Tenen D.G. Purification of a human milk protein closely similar to tumor-secreted phosphoproteins and osteopontin. Biochim Biophys Acta 996 (1989) 43-48
22. Luedtke C.C., McKee M.D., Cyr D.G., Gregory M., Kaartinen M.T., Mui J., et al. Osteopontin expression and regulation in the testis, efferent ducts, and epididymis of rats during postnatal development through to adulthood. Biol Reprod 66 (2002) 1437-1448
23. Brown L.F., Berse B., Van de Water L., Papadopoulos-Sergiou A., Perruzzi C.A., Manseau E.J., et al. Expression and distribution of osteopontin in human tissues: widespread association with luminal epithelial surfaces. Mol Biol Cell 3 (1992) 1169-1180
24. Hotte S.J., Winquist E.W., Stitt L., Wilson S.M., and Chambers A.F. Plasma osteopontin: associations with survival and metastasis to bone in men with hormone-refractory prostate carcinoma. Cancer 95 (2002) 506-512
25. Miyauchi A., Alvarez J., Greenfield E.M., Teti A., Grano M., Colucci S., et al. Recognition of osteopontin and related peptides by an alpha v beta 3 integrin stimulates immediate cell signals in osteoclasts. J Biol Chem 266 (1991) 20369-20374
26. Flores M.E., Norgard M., Heinegard D., Reinholt F.P., and Andersson G. RGD-directed attachment of isolated rat osteoclasts to osteopontin, bone sialoprotein, and fibronectin. Exp Cell Res 201 (1992) 526-530
27. Hruska K.A., Rolnick F., Huskey M., Alvarez U., and Cheresh D. Engagement of the osteoclast integrin alpha v beta 3 by osteopontin stimulates phosphatidylinositol 3-hydroxyl kinase activity. Ann N Y Acad Sci 760 (1995) 151-165
28. Senger D.R., and Perruzzi C.A. Cell migration promoted by a potent GRGDS-containing thrombin-cleavage fragment of osteopontin. Biochim Biophys Acta 1314 (1996) 13-24
29. Agnihotri R., Crawford H.C., Haro H., Matrisian L.M., Havrda M.C., and Liaw L. Osteopontin, a novel substrate for matrix metalloproteinase-3 (stromelysin-1) and matrix metalloproteinase-7 (matrilysin). J Biol Chem 276 (2001) 28261-28267
30. Kousta E., White D.M., Cela E., McCarthy M.I., and Franks S. The prevalence of polycystic ovaries in women with infertility. Hum Reprod 14 (1999) 2720-2723
31. Adams J.M., Taylor A.E., Crowley Jr. W.F., and Hall J.E. Polycystic ovarian morphology with regular ovulatory cycles: insights into the pathophysiology of polycystic ovarian syndrome. J Clin Endocrinol Metab 89 (2004) 4343-4350
32. Apparao K.B., Lovely L.P., Gui Y., Lininger R.A., and Lessey B.A. Elevated endometrial androgen receptor expression in women with polycystic ovarian syndrome. Biol Reprod 66 (2002) 297-304
33. Cermik D., Selam B., and Taylor H.S. Regulation of HOXA-10 expression by testosterone in vitro and in the endometrium of patients with polycystic ovary syndrome. J Clin Endocrinol Metab 88 (2003) 238-243
34. Palomino W.A., Fuentes A., Gonzalez R.R., Gabler F., Boric M.A., Vega M., et al. Differential expression of endometrial integrins and progesterone receptor during the window of implantation in normo-ovulatory women treated with clomiphene citrate. Fertil Steril 83 (2005) 587-593
35. Brosens J., Verhoeven H., Campo R., Gianaroli L., Gordts S., Hazekamp J., et al. High endometrial aromatase P450 mRNA expression is associated with poor IVF outcome. Hum Reprod 19 (2004) 352-356
36. Revised 2003 consensus on diagnostic criteria and long-term health risks related to polycystic ovary syndrome. Fertil Steril 81 (2004) 19-25
37. Adams J., Polson D.W., and Franks S. Prevalence of polycystic ovaries in women with anovulation and idiopathic hirsutism. Br Med J (Clin Res Ed) 293 (1986) 355-359
38. Noyes R.W., and Haman J.O. Accuracy of endometrial dating; correlation of endometrial dating with basal body temperature and menses. Fertil Steril 4 (1953) 504-517
39. Chambers A.F., Wilson S.M., Kerkvliet N., O'Malley F.P., Harris J.F., and Casson A.G. Osteopontin expression in lung cancer. Lung Cancer 15 (1996) 311-323
40. Bautista D.S., Xuan J.W., Hota C., Chambers A.F., and Harris J.F. Inhibition of Arg-Gly-Asp (RGD)-mediated cell adhesion to osteopontin by a monoclonal antibody against osteopontin. J Biol Chem 269 (1994) 23280-23285
41. Budwit-Novotny D.A., McCarty K.S., Cox E.B., Soper J.T., Mutch D.G., Creasman W.T., et al. Immunohistochemical analyses of estrogen receptor in endometrial adenocarcinoma using a monoclonal antibody. Cancer Res 46 (1986) 5419-5425
42. Fisher L.W., Stubbs III J.T., and Young M.F. Antisera and cDNA probes to human and certain animal model bone matrix noncollagenous proteins. Acta Orthop Scand Suppl 266 (1995) 61-65
43. Ruck P., Marzusch K., Kaiserling E., Horny H.P., Dietl J., Geiselhart A., et al. Distribution of cell adhesion molecules in decidua of early human pregnancy. An immunohistochemical study. Lab Invest 71 (1994) 94-101
44. Aplin J.D., Spanswick C., Behzad F., Kimber S.J., and Vicovac L. Integrins beta 5, beta 3 and alpha v are apically distributed in endometrial epithelium. Mol Hum Reprod 2 (1996) 527-534
45. Borthwick J.M., Charnock-Jones D.S., Tom B.D., Hull M.L., Teirney R., Phillips S.C., et al. Determination of the transcript profile of human endometrium. Mol Hum Reprod 9 (2003) 19-33
46. Craig A.M., and Denhardt D.T. The murine gene encoding secreted phosphoprotein 1 (osteopontin): promoter structure, activity, and induction in vivo by estrogen and progesterone. Gene 100 (1991) 163-171
47. Omigbodun A., Ziolkiewicz P., Tessler C., Hoyer J.R., and Coutifaris C. Progesterone regulates osteopontin expression in human trophoblasts: a model of paracrine control in the placenta?. Endocrinology 138 (1997) 4308-4315
48. Homburg R. Polycystic ovary syndrome-from gynaecological curiosity to multisystem endocrinopathy. Hum Reprod 11 (1996) 29-39
49. Hassan M.A., and Killick S.R. Ultrasound diagnosis of polycystic ovaries in women who have no symptoms of polycystic ovary syndrome is not associated with subfecundity or subfertility. Fertil Steril 80 (2003) 966-975
50. Esinler I., Bayar U., Bozdag G., and Yarali H. Outcome of intracytoplasmic sperm injection in patients with polycystic ovary syndrome or isolated polycystic ovaries. Fertil Steril 84 (2005) 932-937
51. Xuan J.W., Hota C., and Chambers A.F. Recombinant GST-human osteopontin fusion protein is functional in RGD-dependent cell adhesion. J Cell Biochem 54 (1994) 247-255
52. Holinka C.F., Hata H., Kuramoto H., and Gurpide E. Responses to estradiol in a human endometrial adenocarcinoma cell line (Ishikawa). J Steroid Biochem 24 (1986) 85-89
53. Osyczka A.M., and Leboy P.S. Bone morphogenetic protein regulation of early osteoblast genes in human marrow stromal cells is mediated by extracellular signal-regulated kinase and phosphatidylinositol 3-kinase signaling. Endocrinology 146 (2005) 3428-3437
54. Knippenberg M., Helder M.N., Zandieh Doulabi B., Wuisman P.I., and Klein-Nulend J. Osteogenesis versus chondrogenesis by BMP-2 and BMP-7 in adipose stem cells. Biochem Biophys Res Commun 342 (2006) 902-908
55. Kusumegi T., Tanaka J., Kawano M., Yonemoto J., Tohyama C., and Sone H. BMP7/ActRIIB regulates estrogen-dependent apoptosis: new biomarkers for environmental estrogens. J Biochem Mol Toxicol 18 (2004) 1-11