Postoperative intravenous infusion of donor-derived transplant acceptance-inducing cells as an adjunct immunosuppressive therapy in a porcine pulmonary allograft model

Transplant International

Volumn 22, Issue 3, 2009, Pages 332-341

  Warnecke, Gregor ^a   Hutchinson, James A ^b   Riquelme, Paloma ^b   Kruse, Bianca ^a   Thissen, Stefanie ^a   Avsar, Murat ^a   Zehle, Gregor ^b   Steinkamp, Thomas ^a   Peters, Carsten ^a   Baumann, Rolf ^a   Gövert, Felix ^b   Ungefroren, Hendrik ^b   Länger, Florian ^a   Simon, André R ^a   Karstens, Johann H ^a   Kaever, Volkhard ^a   Haverich, Axel ^a   Fändrich, Fred ^b   Strüber, Martin ^a  

^a HANNOVER MEDICAL SCHOOL   (Germany)

^b UNIVERSITY HOSPITAL SCHLESWIG HOLSTEIN   (Germany)

Author keywords

Cell based immunotherapy; Macrophage; Transplant acceptance inducing cell

Indexed keywords

MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 1; METHYLPREDNISOLONE; TACROLIMUS;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BRONCHOSCOPY; CELL THERAPY; CLINICAL PROTOCOL; CONTROLLED STUDY; DONOR SELECTION; DRUG BLOOD LEVEL; FEASIBILITY STUDY; FEMALE; GRAFT SURVIVAL; HISTOLOGY; IMMUNOSUPPRESSIVE TREATMENT; INFUSION; LUNG TRANSPLANTATION; MACROPHAGE; MALE; NONHUMAN; OUTCOME ASSESSMENT; POSTOPERATIVE PERIOD; PREOPERATIVE RADIOTHERAPY; PRIORITY JOURNAL; RISK ASSESSMENT; SWINE; THORAX RADIOGRAPHY; TRANSBRONCHIAL BIOPSY; TRANSPLANT ACCEPTANCE INDUCING CELL;

ACUTE DISEASE; ANIMALS; COMBINED MODALITY THERAPY; DISEASE MODELS, ANIMAL; GLUCOCORTICOIDS; GRAFT REJECTION; GRAFT SURVIVAL; IMMUNOPHENOTYPING; IMMUNOSUPPRESSION; IMMUNOSUPPRESSIVE AGENTS; IMMUNOTHERAPY, ADOPTIVE; INFUSIONS, INTRAVENOUS; LUNG TRANSPLANTATION; MACROPHAGES; METHYLPREDNISOLONE; POSTOPERATIVE CARE; SWINE; SWINE, MINIATURE; TACROLIMUS; TRANSPLANTATION CHIMERA; TRANSPLANTATION, HOMOLOGOUS;

EID: 59249083318     PISSN: 09340874     EISSN: 14322277     Source Type: Journal    
DOI: 10.1111/j.1432-2277.2008.00778.x     Document Type: Article

References (31)

1. Hutchinson JA, Riquelme P, Brem-Exner BG, et al. Transplant acceptance-inducing cells as an immune-conditioning therapy in renal transplantation. Transpl Int 2008 21 : 728.
2. Hutchinson JA, Brem-Exner BG, Riquelme P, et al. A cell-based approach to the minimization of immunosuppression in renal transplantation. Transpl Int 2008 21 : 742.
3. Hutchinson JA, Roelen D, Riquelme P, et al. Preoperative treatment of a presensitized kidney transplant recipient with donor-derived transplant acceptance-inducing cells. Transpl Int 2008 21 (8 808.
4. Chatenoud L. The long and winding road towards induction of allograft tolerance in the clinic. Transpl Int 2008 21 : 725.
5. Bluestone JA, Thomson AW, Shevach EM, Weiner HL. What does the future hold for cell-based tolerogenic therapy? Nat Rev Immunol 2007 7 : 650.
6. St Clair EW, Turka LA, Saxon A, et al. New reagents on the horizon for immune tolerance. Annu Rev Med 2007 58 : 329.
7. McCurry KR, Colvin BL, Zahorchak AF, Thomson AW. Regulatory dendritic cell therapy in organ transplantation. Transpl Int 2006 19 : 525.
8. Lechler RI, Sykes M, Thomson AW, Turka LA. Organ transplantation: How much of the promise has been realized? Nat Med 2005 11 : 605.
9. Kawai T, Cosimi AB, Spitzer TR, et al. HLA-mismatched renal transplantation without maintenance immunosuppression. N Engl J Med 2008 358 : 353.
10. Fudaba Y, Spitzer TR, Shaffer J, et al. Myeloma responses and tolerance following combined kidney and nonmyeloablative marrow transplantation: in vivo and in vitro analyses. Am J Transplant 2006 6 : 2121.
11. Scandling JD, Busque S, Dejbakhsh-Jones S, et al. Tolerance and chimerism after renal and hematopoietic-cell transplantation. N Engl J Med 2008 358 : 362.
12. Pirenne J, Takahashi K, Kawai M, et al. Translation into the clinic of an experimentally proven pre-regulatory immunomodulatory protocol for intestinal transplantation: long-term results [abstract #O060]. Transpl Int 2007 20 (S2 17.
13. Fändrich F, Lin X, Chai GX, et al. Preimplantation-stage stem cells induce allogeneic graft tolerance without supplementary host conditioning. Nat Med 2002 8 : 171.
14. Fändrich F, Zhou X, Schlemminger M, Glass B, Lin X, Dreßke B. Future Strategies for Tolerance Induction: A Comparative Study between Hematopoietic Stem Cells and Macrophages. Hum Immunol 2002 63 : 805.
15. Brem-Exner BG, Sattler C, Hutchinson JA, et al. Macrophages driven to a novel state of activation have anti-inflammatory properties in mice. J Immunol 2008 180 : 335.
16. Exner BG, Scherer MN, Koehl GE, et al. Hyperacute rejection of transplanted rat hearts is abrogated by the use of in vitro generated donor-derived transplant-acceptance-inducing cells (TAIC). Transplantation 2004 78 (Suppl. 1 530.
17. Kabelitz D, Geissler EK, Soria B, Schroeder IS, Fändrich F, Chatenoud L. Toward cell-based therapy of type I diabetes. Trends Immunol 2008 29 : 68.
18. Renard C, Kristensen B, Gautschi C, Hruban V, Fredholm M, Vaiman M. Joint report of the first international comparison test on swine lymphocyte alloantigens (SLA). Anim Genet 1988 19 : 63.
19. Strüber M, Hohlfeld JM, Kofidis T, et al. Surfactant function in lung transplantation after 24 hours of ischemia: Advantage of retrograde flush perfusion for preservation. J Thorac Cardiovasc Surg 2002 123 : 98.
20. Yousem SA, Berry GJ, Cagle PT, et al. Revision of the 1990 working formulation for the classification of pulmonary allograft rejection: Lung Rejection Study Group. J Heart Lung Transplant 1996 15 : 1.
21. Kamath AV, Morris ME. Functional expression of P-glycoprotein in the hepatic canalicular membrane of developing rats. J Pharm Sci 1998 87 : 300.
22. Asperen JV, Tellingen OV, Beijnen JH. The pharmacological role of P-glycoprotein in the intestinal epithelium. Pharmacol Res 1998 37 : 429.
23. Wacher VJ, Wu CY, Benet LZ. Overlapping substrate specifities and tissue distribution of cytochrome P450 3A and P-glycoprotein: Implications for drug delivery and activity in cancer chemotherapy. Mol Carcinog 1995 13 : 129.
24. Schuetz EG, Beck WT, Schuetz JD. Modulators and substrates of P-glycoprotein and cytochrome P450 3A coordinately up-regulate proteins in human colon carcinoma cells. Mol Pharmacol 1996 49 : 311.
25. Utsugi R, Barth RN, Lee RS, et al. Induction of transplantation tolerance with a short course of tacrolimus (FK506): I. Rapid and stable tolerance to two-haplotype fully MHC-mismatched kidney allografts in miniature swine. Transplantation 2001 71 : 1368.
26. Warnecke G, Avsar M, Morancho M, et al. Preoperative low-dose irradiation promotes long-term allograft acceptance and induces regulatory T cells in a model of pulmonary transplantation. Transplantation 2006 82 : 93.
27. Warnecke G, Avsar M, Steinkamp T, et al. Tacrolimus versus cyclosporine induction therapy in pulmonary transplantation in miniature swine. Eur J Cardiothorac Surg 2005 28 : 454.
28. Gordon S, Taylor PR. Monocyte and macrophage heterogeneity. Nat Rev Immunol 2005 5 : 953.
29. Mantovani A, Sica A, Locati M. Macrophage polarization comes of age. Immunity 2005 23 : 344.
30. Munn DH, Shafizadeh E, Attwood JT, Bondarev I, Pashine A, Mellor AL. Inhibition of T cell proliferation by macrophage tryptophan catabolism. J Exp Med 1999 189 : 1363.
31. Munn DH, Pressey J, Beall AC, Hudes R, Alderson MR. Selective activation-induced apoptosis of peripheral T cells imposed by macrophages. A potential mechanism of antigen-specific peripheral lymphocyte deletion. J Immunol 1996 156 : 523.