Survival from hypoxia in C. elegans by inactivation of aminoacyl-tRNA synthetases

Science

Volumn 323, Issue 5914, 2009, Pages 630-633

  Anderson, Lori L ^a   Mao, Xianrong ^a   Scott, Barbara A ^a   Crowder, C Michael ^a  

^a WASHINGTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AMINO ACID TRANSFER RNA LIGASE;

DISEASE RESISTANCE; ENZYME ACTIVITY; GENE EXPRESSION; HYPOXIA; INJURY; MUTATION; NEMATODE; PROTEIN; RNA; SURVIVAL;

ARTICLE; CAENORHABDITIS ELEGANS; CELL HYPOXIA; CELL SURVIVAL; DNA POLYMORPHISM; ENZYME INACTIVATION; GENE FREQUENCY; GENETIC SCREENING; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FOLDING; PROTEIN FUNCTION; PROTEIN TRANSPORT;

AMINO ACID SEQUENCE; AMINO ACYL-TRNA SYNTHETASES; ANIMALS; ARGININE-TRNA LIGASE; CAENORHABDITIS ELEGANS; CAENORHABDITIS ELEGANS PROTEINS; CELL HYPOXIA; LONGEVITY; MOLECULAR SEQUENCE DATA; MUSCLE CELLS; MUTATION; NEURONS; OXYGEN; OXYGEN CONSUMPTION; PROTEIN BIOSYNTHESIS; PROTEIN FOLDING; RNA INTERFERENCE; TRANSGENES;

ANIMALIA; CAENORHABDITIS ELEGANS;

EID: 59149097747     PISSN: 00368075     EISSN: 10959203     Source Type: Journal    
DOI: 10.1126/science.1166175     Document Type: Article

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27. We thank M. Mabon for early efforts on screen design, L. Metz for technical help, and M. Hansen for advice and strains. Supported by the National Institute of Neurological Disorders and Stroke, a Neuroscience of Brain Disorders Award from the McKnight Endowment Fund for Neuroscience, and an American Heart Association Established Investigator Award. Some of the strains used in this work were provided by the Caenorhabditis Genetics Center, which is funded by the NIH National Center for Research Resources.