Zeneca zd6169 activates atp-sensitive k+ channels in the urinary bladder of the guinea pig

Pharmacology

Volumn 53, Issue 3, 1996, Pages 170-179

  Heppner, Thomas J ^a   Bouev, Adrian ^a   Li, Jack H ^b   Kau, Sen T ^b   Nelson, Mark T ^a  

^a UNIVERSITY OF VERMONT COLLEGE OF MEDICINE   (United States)

^b ASTRAZENECA   (United Kingdom)

Author keywords

Anilide tertiary carbinols; ATP sensitive potassium channels; Guinea pig detrusor; Levcromakalim; Urinary incontinence; ZD6169

Indexed keywords

ADENOSINE TRIPHOSPHATE; GLIBENCLAMIDE; LEMAKALIM; METHANOL DERIVATIVE; N (4 BENZOYLPHENYL) 3,3,3 TRIFLUORO 2 HYDROXY 2 METHYLPROPIONAMIDE; POTASSIUM CHANNEL; PROTEIN KINASE C; PROTEIN KINASE C ACTIVATOR; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL TISSUE; ARTICLE; BLADDER; CONTROLLED STUDY; DRUG EFFECT; GUINEA PIG; HYPERPOLARIZATION; MUSCLE FIBER MEMBRANE POTENTIAL; NONHUMAN; PH; POTASSIUM CURRENT; PRIORITY JOURNAL;

ADENOSINE TRIPHOSPHATE; AMIDES; ANIMALS; BENZOPHENONES; BENZOPYRANS; CROMAKALIM; DOSE-RESPONSE RELATIONSHIP, DRUG; ENZYME ACTIVATION; GLYBURIDE; GUINEA PIGS; HYDROGEN-ION CONCENTRATION; ION CHANNEL GATING; MEMBRANE POTENTIALS; MUSCLE, SMOOTH; POTASSIUM CHANNELS; PROTEIN KINASE C; PYRROLES; URINARY BLADDER;

EID: 0029974037     PISSN: 00317012     EISSN: 14230313     Source Type: Journal    
DOI: 10.1159/000139428     Document Type: Article

References (24)

1. Ohnmacht CJ, Russell K, Frank CA, Gibson KH, McLaren FM, Shapiro HS, Brown FJ, Trainor DA, Emp-field JR, Frost JM, Harris RJ, Hul-sizer JM, Lewis JJ, Mayhugh DR, Silverman SM, Smith RW, Warwick PJ: The discovery of bladder selective K, vn> openers in a series of anilide tertiary carbinols, The selection of ZD6169, FASEB J 1994:8: A91.
2. Kau ST, Howe BB, Li JH, Pcttingcr SJ, Trivedi S, Halterman TJ, Stetz SL, Stow RB, Yasay GD, Yochini CL: Zeneca ZD6I69: An antispas-modic agent selective for urinary bladder, FASEB J 1994;8:A91.
3. 8
4. atp channel opening activity in bladder detrusor, Pharmacology 1995:51: 33-42.
5. Fujii K: Evidence for adenosine triphosphate as an excitatory transmitter in guinea-pig, rabbit and pig urinary bladder, J Physiol 1988;404: 39-52.
6. Foster CD, Fujii K, Kingdon J, Brading AF: The effect of cromakalim on the smooth muscle of the guinea-pig urinary’ bladder, Br J Pharmacol 1989:97:281-291.
7. Hamill OP, Marty A, Neher E, Sack-mann B, Sigworth FJ: Improved patch-clamp techniques for high-rc-solulion current from cells and cell-free membrane patches, Pfliigcrs Arch 1981;391:85-100.
8. Boncv AD, Nelson MT: ATP-sensi-tive potassium channels in smooth muscle cells from guinea pig urinary bladder, Am J Physiol 1993:264: C1190-1200.
9. Boncv AD, Nelson MT: Muscarinic inhibition of ATP-sensitive K* channels by protein kinase C in urinary’ bladder smooth muscle, Am J Physiol 1993;265:0723-0728.
10. Quayle JM, Bonev AD, Braydcn JE, Nelson MT: Calcitonin gene-related peptide activated ATP-sensitive K* currents in rabbit arterial smooth muscle via protein kinase A, J Physiol 1994:475.1:9-13.
11. Zhang L, Bonev AD, Mawe GM, Nelson MT: Protein kinase A mediates activation of ATP-sensitive K’ currents by CGRP in gallbladder smooth muscle, Am J Physiol 1994: 267:G494-G499.
12. Xu X, Kai SL: Characterization of the ATP-inhibited K’ current in canine coronary smooth muscle cells, Pfliigcrs Arch 1994:427:110-120.
13. −currents in smooth muscle cells from rabbit mesenteric artery, Am J Physiol 1995:38: C1112-C1118.
14. Nichols CG, Lcderer WJ: Adenosine triphosphate-sensitive potassium channels in the cardiovascular system, Am J Physiol 1991:261: H1675-H1686.
15. Klockner U, Isenberg G: Action potentials and net membrane currents of isolated smooth muscle cells (urinary bladder of the guinea-pig), PfliigersArch 1985:405:329-339.
16. Zografos P, Li J H, Kau ST: Comparison of the in vitro effects of K’ channel modulators on detrusor and portal vein strips from guinea pigs, Pharmacology 1992:45:216-230.
17. Misler S, Gillis K, Tabacharani J: Modulation of gating of a metabolite regulated, ATP-dependent K* channel by internal pH in fl cells of the pancreatic islet, J Membr Biol 1989: 109:135-143.
18. Davies NW: Modulation of ATP-sensitive K* channels in skeletal muscle by intracellular protons, Nature 1990:343:375-377.
19. Lederer WJ, Nichols CG: Nucleotide modulation of the activity of rat heart K vn> channels in membrane patches, J Physiol 1990:419:193-213.
20. Ashcroft SH, Ashcroft FM: Properties and functions of ATP-sensitive K-channels, Cell Signal 1990;2:197-214.
21. Meisheri KD, Sajida AK, Martin JL: Vascular pharmacology of ATP-sensitive K* channels: Interactions between glyburide and K* channel openers, J Vase Res 1993;30:2-12.
22. Yantane T, Furukawa T, Horikawa S, Hiraoka M: External pH regulates the slowly activating potassium current first expressed in Xenopus oocytes, FEBSlett 1993:319:229-232.
23. Deutsch C, Lee SC: Modulation of K* currents in human lymphocytes by pH, J Physiol 1989:413:399-413.
24. Kleppisch T, Nelson MT: Adenosine activates ATP-sensitive potassium channels in arterial myocytes via Ay receptors and cAMP-dcpen-dent protein kinase, Proc Natl Acad Sci USA 1995:92:12441-12445.