Mechanisms of synergistic cytokine-induced nitric oxide production in human alveolar epithelial cells

Nitric Oxide - Biology and Chemistry

Volumn 5, Issue 6, 2001, Pages 534-546

  Kwon, Soonjo ^a   Newcomb, Robert L ^a   George, Steven C ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

A549; Cytomix; iNOS; Tetrahydrobiopterin

Indexed keywords

CYTOKINE; FLAVINE ADENINE NUCLEOTIDE; FLAVINE MONONUCLEOTIDE; GAMMA INTERFERON; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERLEUKIN 1BETA; MONOMER; NITRIC OXIDE; NITRIC OXIDE SYNTHASE; TETRAHYDROBIOPTERIN; TRANSCRIPTION FACTOR; TUMOR NECROSIS FACTOR ALPHA;

ARTICLE; BIOSYNTHESIS; CELL NUCLEUS; CELL STRAIN; CONTROLLED STUDY; CYTOSOL; ENZYME SYNTHESIS; HUMAN; HUMAN CELL; INFLAMMATION; LUNG ALVEOLUS EPITHELIUM; NONLINEAR SYSTEM; PRIORITY JOURNAL; PROTEIN PROTEIN INTERACTION; PROTEIN TRANSPORT; TRANSCRIPTION REGULATION;

EID: 0035668234     PISSN: 10898603     EISSN: None     Source Type: Journal    
DOI: 10.1006/niox.2001.0387     Document Type: Article

References (32)

1. Endothelium derived relaxing factor produced and released from artery and vein is nitric oxide
2. Inhalations of nitric oxide modulates adult human bronchial tone
3. L-Arginine-dependent nitric oxide synthase: A new metabolic pathway in the lung and airways
4. Nitric oxide and airway disease
5. Multiple NF-κB enhancer elements regulate cytokine induction of the human inducible nitric oxide synthase gene
6. The biology of nitrogen oxides in the airways
7. Interactions between respiratory epithelial cells and cytokines: Relationships to lung inflammation
8. Human lung mononuclear cells induce nitric oxide synthase in murine airway epithelial cells in vitro: Role of TNF-α and IL-1β
9. Cytokine-induced nitric oxide formation in normal but not in neoplastic murine lung epithelial cell lines
10. Transcriptional regulation of iNOS by IL-1 beta in cultured rat pulmonary artery smooth muscle cells
11. Synergism between interleukin-1β and interferon-γ, an inducer of nitric oxide synthase, in rat lung fibroblasts
12. Synergistic cytokine-induced nitric oxide production in human alveolar epithelial cells
13. Oxidative stress induces NF-κB DNA binding and inducible NOS mRNA in human epithelial cells
14. Role of transcription factor NF-κB/Rel in induction of nitric oxide synthase
15. Cytokine-mediated transcriptional induction of the human inducible nitric oxide synthase gene requires both activator protein 1 and nuclear factor kappaB-binding sites
16. Analysis of the cytokine-stimulated human inducible nitric oxide synthase (iNOS) gene: Characterization of differences between human and mouse iNOS promoters
17. Role of tetrahydrobiopterin availability in the regulation of nitric-oxide synthase expression in human mesangial cells
18. Macrophage nitric oxide synthase subunit. Purification, characterization, and role of prosthetic groups and substrate in regulating their association into a dimeric enzyme
19. Tetrahydrobiopterin, a cofactor for rat cerebellar nitric oxide synthase, does not function as a reactant in the oxygenation of arginine
20. The NF-κB and IκB proteins: New discoveries and insights
21. Role of interferon regulatory factor 1 in induction of nitric oxide synthase
22. NF-κB controls expression of inhibitor IκBα: Evidence for an inducible autoregulatory pathway
23. Autoregulation of IκBα activity
24. Promoter analysis of the gene coding the IκBα/MAD-3 inhibitor of NF-κB: Positive regulation by members of the rel/NF-κB family
25. Inducible nuclear expression of newly synthesized IκBα negatively regulates DNA-binding and transcriptional activities of NF-κB
26. IκBα can localize in the nucleus but shows no direct transactivation potentials
27. Cytokine-induced changes in chromatin structure and in vivo footprints in the inducible NOS promoter
28. Regulation of biosynthesis of nitric oxide
29. Tetrahydrobiopterin, cytokines, and nitric oxide synthesis
30. Macrophage nitric oxide synthase. Relationship between enzyme-bound tetrahydrobiopterin and synthase activity
31. Kinetics and mechanism of tetrahydrobiopterin-induced oxidation of nitric oxide