Application of multi-factorial design of experiments to successfully optimize immunoassays for robust measurements of therapeutic proteins

Journal of Pharmaceutical and Biomedical Analysis

Volumn 49, Issue 2, 2009, Pages 311-318

  Ray, Chad A ^a   Patel, Vimal ^a   Shih, Judy ^a   Macaraeg, Chris ^a   Wu, Yuling ^a   Thway, Theingi ^a   Ma, Mark ^a   Lee, Jean W ^a   DeSilva, Binodh ^a  

^a AMGEN INC   (United States)

Author keywords

Immunoassay; Method optimization; Method validation; Multi factorial experimental design; Therapeutic proteins

Indexed keywords

PROTEIN;

ARTICLE; AUTOMATION; IMMUNOASSAY; LIGAND BINDING; MATHEMATICAL ANALYSIS; PRIORITY JOURNAL; PROCESS DESIGN; PROCESS OPTIMIZATION; SCREENING; VALIDATION PROCESS;

AUTOMATION; AVIDIN; DATA INTERPRETATION, STATISTICAL; ENZYME-LINKED IMMUNOSORBENT ASSAY; HORSERADISH PEROXIDASE; IMMUNOASSAY; INDICATORS AND REAGENTS; LIGANDS; LUMINESCENCE; LUMINESCENT MEASUREMENTS; MODELS, STATISTICAL; PROTEIN BINDING; PROTEINS; RECOMBINANT PROTEINS; REPRODUCIBILITY OF RESULTS; RESEARCH DESIGN; STREPTAVIDIN; TIME FACTORS;

EID: 59049104131     PISSN: 07317085     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jpba.2008.11.039     Document Type: Article

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