Quality by design: Understanding the formulation variables of a cyclosporine A self-nanoemulsified drug delivery systems by Box-Behnken design and desirability function

International Journal of Pharmaceutics

Volumn 332, Issue 1-2, 2007, Pages 55-63

  Zidan, Ahmed S ^a,b,c   Sammour, Omaima A ^b   Hammad, Mohammed A ^b   Megrab, Nagia A ^b   Habib, Muhammad J ^c   Khan, Mansoor A ^a  

^a CENTER FOR DRUG EVALUATION AND RESEARCH   (United States)

^b Zagazig University   (Egypt)

^c HOWARD UNIVERSITY   (United States)

Author keywords

Box Behnken; Cyclosporine; Optimization; Quality by design; Self nanoemulsification

Indexed keywords

CYCLOSPORIN A; NANOPARTICLE; OCTANOIN; RICINOMACROGOL;

ARTICLE; DRUG BIOAVAILABILITY; DRUG DELIVERY SYSTEM; DRUG DESIGN; DRUG QUALITY; MATHEMATICAL MODEL; MICROEMULSION; PARTICLE SIZE; PRIORITY JOURNAL; PROCESS OPTIMIZATION; SCALE UP; TURBIDIMETRY;

ANALYSIS OF VARIANCE; CHEMISTRY, PHARMACEUTICAL; CYCLOSPORINE; DRUG COMPOUNDING; DRUG DELIVERY SYSTEMS; EMULSIONS; FACTOR ANALYSIS, STATISTICAL; GLYCERIDES; IMMUNOSUPPRESSIVE AGENTS; LINEAR MODELS; NANOPARTICLES; NANOTECHNOLOGY; NEPHELOMETRY AND TURBIDIMETRY; OCTANOIC ACIDS; PLANT OILS; POLYETHYLENE GLYCOLS; PREDICTIVE VALUE OF TESTS; QUALITY CONTROL; REPRODUCIBILITY OF RESULTS; SOLUBILITY; SOLVENTS; SURFACE-ACTIVE AGENTS; TECHNOLOGY, PHARMACEUTICAL; TIME FACTORS;

EID: 33846852628     PISSN: 03785173     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ijpharm.2006.09.060     Document Type: Article

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