Hepatic ultrastructural mitochondrial changes prior to antiretroviral therapy in HIV-infected patients in Brazil

Journal of the International Association of Physicians in AIDS Care

Volumn 7, Issue 5, 2008, Pages 252-258

  Mendes Corrêa, Maria Cássia ^a   Andrade Jr , Heitor Franco ^a   Fumica Takakura, Cleusa ^a   Seixas Duarte, Maria Irma ^a  

^a UNIVERSITY OF SÃO PAULO   (Brazil)

Author keywords

antiretroviral drugs; HIV; liver; mitochondria; ultrastructural changes

Indexed keywords

ANTI HUMAN IMMUNODEFICIENCY VIRUS AGENT; DIDANOSINE; RNA DIRECTED DNA POLYMERASE INHIBITOR; ZIDOVUDINE;

ARTICLE; BIOPSY; BRAZIL; FEMALE; HUMAN; HUMAN IMMUNODEFICIENCY VIRUS 1; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; LIVER; MALE; MITOCHONDRION; PATHOGENICITY; PATHOLOGY; ULTRASTRUCTURE; VIROLOGY;

ANTI-HIV AGENTS; BIOPSY; BRAZIL; DIDANOSINE; FEMALE; HIV INFECTIONS; HIV-1; HUMANS; LIVER; MALE; MITOCHONDRIA; REVERSE TRANSCRIPTASE INHIBITORS; ZIDOVUDINE;

EID: 59049084022     PISSN: 15451097     EISSN: 15570886     Source Type: Journal    
DOI: 10.1177/1545109708321860     Document Type: Article

References (24)

1. Bica I., McGovern B., Dhar R., et al. Increasing mortality due to end-stage liver disease in patients with human immunodeficiency virus infection. Clin Infect Dis. 2001 ; 32: 492-497. (Pubitemid 32173638)
2. Martin-Carbonero L., Soriano V., Valencia A., et al. Increasing impact of chronic viral hepatitis on hospital admissions and mortality among HIV-infected patients. AIDS Res Hum Retroviruses. 2001 ; 17: 1467-1471. (Pubitemid 33116749)
3. Pol S., Lebray P., Vallet-Pichard,A. HIV infection and hepatic enzyme abnormalities: intricacies of the pathogenic mechanisms. Clin Infect Dis. 2004 ; 38 (suppl 2). S65 - S72.
4. Nunez M., Soriano V. Hepatotoxicity of antiretrovirals: incidence, mechanisms and management. Drug Saf. 2005 ; 28: 53-66.
5. McComsey G. Update on mitochondrial toxicity of antiretrovirals and its link to lipodystrophy. AIDS Rev. 2002 ; 4: 140-147. (Pubitemid 35251991)
6. de Mendoza C., Blanco F., Soriano V. Mitochondrial damage by antiretrovirals: diagnosis and monitoring. Med Clin (Barc). 2003 ; 121: 310-315.
7. de Mendoza C., Sanches-Conde M., Ribera E., Domingo P., Soriano V. Could mitochondrial DNA quantitation be a surrogate marker for drug mitochondrial toxicity ? AIDS Rev. 2004 ; 6: 169-180. (Pubitemid 39599987)
8. Guillaume MP, De Prez C., Cogan E. Subacute mitochondrial liver disease in a patient with AIDS: possible relationship to prolonged fluconazole administration. Am J Gastroenterol. 1996 ; 91: 165-168.
9. Shapiro SH, Klavins JV Concentric membranous bodies and giant mitochondria in hepatocytes from a patient with AIDS. Ultrastruct Pathol. 1993 ; 17: 557-563. (Pubitemid 23317840)
10. Radovanovic J., Todorovic V., Boricic I., Jankovic-Hladni M., Korac A. Comparative ultrastructural studies on mitochondrial pathology in the liver of AIDS patients: clusters of mitochondria, protuberances, "minimitochondria, " vacuoles, and virus-like particles. Ultrastruct Pathol. 1999 ; 23: 19-24. (Pubitemid 29115495)
11. Scoazec JY, Marche C., Girard PM, et al. Peliosis hepatis and sinusoidal dilation during infection by the human immunodeficiency virus (HIV): an ultrastructural study. Am J Pathol. 1988 ; 131: 38-47.
12. Van Huyen JP, Landau A., Piketty C., et al. Toxic effects of nucleoside reverse transcriptase inhibitors on the liver: value of electron microscopy analysis for the diagnosis of mitochondrial cytopathy. Am J Clin Pathol. 2003 ; 119: 546-555.
13. Verucchi G., Calza L., Biagetti C., et al. Ultrastructural liver mitochondrial abnormalities in HIV/HCV-coinfected patients receiving antiretroviral therapy. J Aquir Immune Defic Syndr. 2004 ; 35: 326-328. (Pubitemid 38280663)
14. Duarte MI, Uip DE, Oliveira MS Fgado e AIDS. In: Gayotto LCC, Alves VAF, eds. Doenas do fgado e vias biliares. Vol 2. São Paulo, Brazil: Editora Atheneu ; 2001: 915-929.
15. Duarte MI, Olisnei NM, Takakura CF, Everson D., Corbett CE A fast method for processing biologic material for electron microscopic diagnosis in infectious disease Ultrastruct Pathol. 1992 ;16: 475-482.
16. Cossarizza A., Moyle G. Antiretroviral nucleoside and nucleotide analogues and mitochondria. AIDS. 2004 ; 18: 137-151. (Pubitemid 38253435)
17. Vittecoq D., Jardel C., Barthelemy C., et al. Mitochondrial damage associated with long-term antiretroviral treatment: associated alteration or causal disorder ? J Acquir Immune Defic Syndr. 2002 ; 31: 299-308. (Pubitemid 35278630)
18. Ferri KF, Jacotot E., Blanco J., Este JA, Kroemer G. Mitochondrial control of cell death induced by HIV-1-encoded proteins. Ann N Y Acad Sci. 2000 ; 926: 149-164. (Pubitemid 32050153)
19. Okuda M., Li K., Beard MR, et al. Mitochondrial injury, oxidative stress, and antioxidant gene expression are induced by hepatitis C virus core protein. Gastroenterology. 2002 ; 122: 366-375. (Pubitemid 34116988)
20. Barbaro G., Di Lorenzo G., Asti A., et al. Hepatocellular mitochondrial alterations in patients with chronic hepatitis C: ultrastructural and biochemical findings. Am J Gastroenterol. 1999 ; 94: 2198-2205. (Pubitemid 29374554)
21. Banasiewicz T., Marszalek A., Majewski P., Marciniak R., Zielinski M. The influence of partial gastrectomy on the ultrastructural changes in the liver: an experimental animal model. Rocz Akad Med Bialymst. 1997 ; 42 (suppl 2). 56-62.
22. Albukerk J., Duffy JL Ultrastructural alterations in livers with metastasis. Arch Pathol Lab Med. 1976 ; 100: 168-171. (Pubitemid 8207856)
23. Jozsa L., Reffy A., Demel S., Szilagyi I. Ultrastructural changes in human liver cells due to reversible acute hypoxia. Hepatogastroenterology. 1981 ; 28: 23-26. (Pubitemid 11184206)
24. Finol HJ, Mondragon DD, Gonzalez YM, Marquez A., Gonzales N., Paradisi C. Hepatocyte ultrastructural alterations in cocaine users. J Submicrosc Cytol Pathol. 2000 ; 32: 111-116.