Neurobiology of sleep fragmentation: Cortical and autonomic markers of sleep disorders

Current Pharmaceutical Design

Volumn 14, Issue 32, 2008, Pages 3474-3480

  Janackova, Sona ^a   Sforza, Emilia ^a  

^a REIMS UNIVERSITY HOSPITAL   (France)

Author keywords

Arousal; Autonomic activation; Cortical activation; Diurnal consequences; Sleep disorders; Sleep fragmentation; Sleepiness

Indexed keywords

APNEA; AROUSAL; ARTERY TONE; AUTONOMIC NERVOUS SYSTEM; BLOOD PRESSURE VARIABILITY; BRAIN BLOOD FLOW; BRAIN DEPTH STIMULATION; BRAIN FUNCTION; DAYTIME SOMNOLENCE; ELECTROENCEPHALOGRAPHY; EVOKED CORTICAL RESPONSE; HEART RATE VARIABILITY; HUMAN; NEUROBIOLOGY; PATHOPHYSIOLOGY; PRIORITY JOURNAL; PULSE PRESSURE; PULSE WAVE; REFLEX; REM SLEEP; REVIEW; SLEEP APNEA SYNDROME; SLEEP DEPRIVATION; SLEEP DISORDER; SLEEP FRAGMENTATION; SLEEP PARAMETERS; SLEEP TIME; SLEEP WAKING CYCLE; SYMPATHETIC TONE; TACHYCARDIA; BRAIN CORTEX; METABOLISM; PHYSIOLOGY;

BIOLOGICAL MARKER;

AROUSAL; AUTONOMIC NERVOUS SYSTEM; BIOLOGICAL MARKERS; CEREBRAL CORTEX; HUMANS; NEUROBIOLOGY; SLEEP DEPRIVATION; SLEEP DISORDERS;

EID: 58949101993     PISSN: 13816128     EISSN: None     Source Type: Journal    
DOI: 10.2174/138161208786549335     Document Type: Review

References (91)

1. Mignot E. Why we sleep: The temporal organization of recovery. PLoS Biol 2008; 6: E106.
2. Kahn A, Grosswasser J, Franco P, Scaiullet S, Sawaguchi T, Kelmason E, et al. Sudden infant deaths: Arousal as a survival mechanisms. Sleep Med 2003; 2: 11-4.
3. Horner RL. Autonomic consequences of arousal from sleep: Mechanism and implication. Sleep 1996; 19: 193-5.
4. Dang-Vu TT, Desseilles M, Petit D, Mazza S, Montplaisir J, Maquet P. Neuroimaging in sleep medicine. Sleep Med 2007; 8: 349-72.
5. Steriade M, Timofeev I. Neuronal plasticity in thalamocortical networks during sleep and waking oscillations. Neuron 2003; 37: 563-76.
6. Akerstedt T, Billiard M, Bonnet M, et al. Awakening from sleep. Sleep Med Rev 2002; 6: 267-86.
7. American Sleep Disorders Association. The Atlas Task Force. EEG arousals: Scoring rules and examples. Sleep 1992; 15: 174-84.
8. Collard P, Dury M, Delguste P, Aubert G, Rodenstein DO. Movement arousals and sleep-related disordered breathing in adults. Am J Respir Crit Care Med 1996; 154: 454-9.
9. Schieber JP, Muzet A, Feriere PJR. Les phases d'activation transitoire spontanée au cours du sommeil normal chez l'homme. Arch Sci Physiol 1971; 25: 443-65.
10. Halasz P, Terzano M, Parrino L, Bodiz S. The nature of arousal in sleep. J Sleep Res 2004; 13: 1-23.
11. Kotajima F, Meadows GE, Morrell MJ, Corfield DR. Cerebral blood flow changes associated with fluctuations in alpha and theta rhythm during sleep onset in humans. J Physiol 2005; 568: 305-13.
12. Bangash MF, Xie A, Skatrud JB, Reichmuth KJ, Barczi SR, Morgan BJ. Cerebrovascular response to arousal from NREM and REM sleep. Sleep 2008; 31: 321-7.
13. Catcheside PG, Chiong SC, Orr RS, Mercer J, Saunders NA, Mc Evoy RD. Acute cardiovascular responses to arousal from non-REM sleep during normoxia and hypoxia. Sleep 2001; 8: 895-902.
14. Catcheside PG, Orr RS, Chiong SC, Mercer J, Saunders NA, McEvoy RD. Noninvasive cardiovascular markers of acoustically induced arousal from non-rapid-eye-movement sleep. Sleep 2002; 25: 797-804.
15. Launois SH, Averill N, Abraham JH, Kirby DA, Weiss JW. Cardiovascular responses to nonrespiratory and respiratory arousals in a porcine model. J Appl Physiol 2001; 1:114-20.
16. Nalivaiko E, Catcheside PG, Adams A, Jordan AS, Eckert DJ, Mc Evoy RD. Cardiac changes during arousals from non-REM sleep in healthy volunteers. Am J Physiol Regul Integ Comp Physiol 2007; 292: R1320-R27.
17. Silvani A. Physiological sleep-dependent changes in arterial blood pressure: Central autonomic commands and baroreflex control. Clin Exp Pharmacol Physiol 2008; in press
18. Carley DW, Applebaum R, Basner RC, Onal E, Lopata M. Respiratory and arousal responses to acoustic stimulation. Chest 1997; 112: 1567-71
19. Pitson DJ, Stradling JR. Autonomic markers of arousal during sleep in patients undergoing investigation for obstructive sleep apnoea, their relationship to EEG arousal, respiratory events and subjective sleepiness. J Sleep Res 1998; 7: 53-9.
20. Sforza E, Jouny C, Ibanez V. Cardiac activation during arousal in humans: Further evidence for hierarchy in the arousal response. Clin Neurophysiol 2000; 111: 1611-9.
21. Sforza E, Jouny C, Ibanez, V. Time-dependent variation in cerebral and autonomic activity during periodic leg movements in sleep: Implications for arousal mechanisms. Clin Neurophysiol 2002; 113: 883-91.
22. Pillar G, Bar A, Shilner A, Schnall R, Lavie P. Autonomic arousal index: an automated detection based on peripheral arterial tonometry. Sleep 2002; 24: 543-9.
23. Schwartz DJ, Moxley P, Barker A, Longman M. On a characteristic of cortical arousals in individuals with obstructive sleep apnea. J Clin Sleep Med 2005; 1: 35-40.
24. Halasz P. K-complex, a reactive EEG graphoelement of NREM sleep: An old chap in a new garment. Sleep Med Rev 2005; 9: 391-412.
25. Sforza E, Nicolas A, Lavigne G, Gosselin A, Petit D, Montplaisir J. EEG and cardiac activation during periodic leg movements in sleep. Support for a hierarchy of arousal responses. Neurology 1999; 52: 786-91.
26. Sforza E, Pichot V, Barthélémy JC, Haba-Rubio J, Roche F. Cardiovascular variability during periodic leg movements: A spectral analysis approach. Clin Neurophysiol 2005; 116: 1096-1104.
27. Rees K, Spence DP, Earis JE, Calverley P. Arousal responses from apneic events during non-rapid-eye-movement sleep. Am J Respir Crit Care Med 1995; 152: 1016-21.
28. Hamel E. Perivascular nerves and the regulation of cerebrovascular tone. J Appl Physiol 2006; 100:1059-64.
29. Berridge CW, Wathrhouse BD. The locus coeruleus noradrenergic system: modulation of behavioral state and state-dependent cognitive processes. Brain Res Rev 2003; 42: 33-84.
30. Foote SL, Aston-Jones G, Bloom FE. Impulse activity of locus coeruleus neurons in awake rats and monkeys is a function of sensory stimulation and arousal. Proc Natl Acad Sci 1980; 77: 3033-7.
31. Moruzzi G. The physiological properties of the brain stem reticular system. In: Adrian ED, Bremer F, Jasper HH, eds. Brain mechanisms and consciousness. Oxford, Blackwell, 1954: 21-48.
32. Berlucchi G. One or many arousal systems? Reflections on some Giuseppe Moruzzi foresights and insights about the intrinsic regulation of brain activity. Archives Italiennes de Biologie 1997; 135: 5-14.
33. McNamara F, Wulbrand H, Thach BT. Characteristics of the infant arousal response. J Appl Physiol 1998; 85: 2314-21.
34. Katz ES, Lutz J, Black C, Marcus CL. Pulse transit time as a measure of arousal and respiratory effort in children with sleepdisordered breathing. Pediatric Res 2003; 53: 580-8.
35. Steriade M, McCarley RW. In: Brainstem control of wakefulness and sleep. New York Plenum Press, 1990.
36. Langhorst P, Stroh-Werz M, Dittmar K, Camerer H. Facultative coupling of reticular neuronal activity with peripheral cardiovascular and central cortical rhythms. Brain Res 1975; 87: 407-18.
37. De Gennaro L, Ferrara M, Bertini M. EEG arousals in normal sleep: variations by total and selective sleep deprivation. Sleep 2001; 24: 673-9.
38. Sforza E, Chapotot F, Pigeau R, Paul PN, Buguet A. Effects of sleep deprivation on spontaneous arousals in humans. Sleep 2004; 27: 1068-75.
39. Trinder J, Allen N, Kleiman J, Kralevski V, Kleverlaan D, Anson K, et al. On the nature of cardiovascular activation at an arousal from sleep. Sleep 2003; 26: 543-51.
40. Bonnet MH, Arand DL. Heart rate variability: Sleep stage, time of night and arousal influences. Electroencephalogr Clin Neurophysiol 1997; 102: 390-96.
41. McNamara F, Issa FG, Sullivan CE. Arousal pattern following central and obstructive breathing abnormalities in infants and children. J Appl Physiol 1996; 6: 2651-7.
42. Lopes MC, Marcus CL. The significance of ASDA arousals in children. Sleep Med 2007; 9: 3-8.
43. McNamara F, Lijoowska AS, Thach BT. Spontaneous arousal activity in infants during NREM and REM sleep. J Physiol 2002; 538: 263-9.
44. Yakovlev PI, Lecours AR. The myelogenetic cycles of regional maturation of the brain. In: Minlowski A, ed. Regional development of the brain in early life. Philadelphia, FA Davis, 1967.
45. Read PA, Horne RS, Cranage SM, Walker AM, Walker DW, Adamson TM. Dynamic changes in arousal threshold during sleep in the human infant. Pediatr Res 1998; 43: 697-703.
46. Wulbrand H, McNamara F, Thach BT. The role of arousal related brainstem reflexes in causing recovery from upper airway occlusion in infants. Sleep 2008; 31: 833-40.
47. Voss U. Functions of sleep architecture and the concept of protective fields. Rev Neurosci 2004; 15: 33-46.
48. Boselli M, Parrino L, Smerieri A, Terzano MG. Effect of age on EEG arousals in normal sleep. Sleep 1998; 21: 351-7.
49. Goff EA, O'Driscoll DM, Simonds AK, Trinder J, Morrell MJ. The cardiovascular response to arousal from sleep decreases with age in healthy adults. Sleep 2008; 31:1009-17.
50. Gosselin N, Michaud M, Carrier J, Lavigne G, Montplaisir J. Age difference in heart rate changes associated with micro-arousals in humans. Clin Neurophysiol 2002; 113: 517-21.
51. Jordan AS, Eckberg DJ, Catcheside PG, McEvoy RD. Ventilatory response to brief arousal from non-rapid eye movement sleep is greater in men than in women. Am J Respir Crit Care Med 2003; 168: 1512-19.
52. Silvani A, Bojic T, Cianci T, Franzini C, Lodi CA, Predier S, et al. Effects of acoustic stimulation on cardiovascular regulation during sleep. Sleep 2003; 2: 201-5.
53. Yang CK, Jordan AS, White DP, Winkelman JW. Heart rate response to respiratory event with or without leg movements. Sleep 2006; 29: 553-6.
54. Griefahn B, Brode P, Marks A, Basner M. Autonomic arousal related to traffic noise during sleep. Sleep 2008; 31: 569-77.
55. Williams HL, Hammack JT, Daly RL, Dement WC, Lubin A. Responses to auditory stimulation, sleep loss and the EEG stages of sleep. Electroncephalogr Clin Neurophysiol 1964; 16: 269-79.
56. Sforza E, Krieger J, Petiau C. Arousal threshold to respiratory stimuli in OSA patients: Evidence for a sleep-dependent temporal rhythm. Sleep 1999; 22: 69-75.
57. Halasz P, Kundra O, Rajna P, Pal I, Vargha M. Micro-arousals during nocturnal sleep. Acta Physiol Acad Sci Hung 1979; 54: 1-12.
58. Terzano MG, Parrino L, Boselli M, Smerieri A, Spaggiari MC. CAP components and EEG synchronisation in the first three sleep cycles. Clin Neurophysiol 2000; 111: 283-90.
59. Franco P, Scaillet S, Valente F, Chabanski S, Groswasser J, Kahn A. Ambient temperature is associated with changes in infants' arousability from sleep. Sleep 2001; 24: 325-9.
60. Sforza E, Chapotot F, Pigeau R, Buguet A. Time of night and first night effects on arousal reponse in healthy adults. Clin Neurophysiol 2008; 119: 1590-9.
61. Bonnet MH, Arand DL. Performance and cardiovascular measures in normal adults with extreme MSLT scores and subjective sleepiness levels. Sleep 2005; 28: 685-93.
62. Sforza E, Haba-Rubio J. Night-to-night variability in periodic leg movements in patients with restless legs syndrome. Sleep Med 2005; 6: 259-67.
63. Adams N, Strauss M, Schluchter M, Redline S. Relation of measures of sleep-disordered breathing to neuropsychological functioning. Am J Respir Crit Care Med 2001; 163: 1626-31.
64. Roche F, Pichot V, Sforza E, Court-Fortune I, Duverney D, Costes F, et al. Predicting sleep apnoea syndrome from heart period: A time-frequency wavelet analysis. Eur Respir J 2003; 22: 937-42.
65. Sforza E, Pichot V, Cervena K, Barthelemy JC, Roche F. Cardiac variability and heart-rate increment as a marker of sleep fragmentation in patients with a sleep disorder: A preliminary study. Sleep 2007; 30: 43-51.
66. Basner M, Griefahn M, Müller U, Plath G, Samel A. An ECG-based algorithm for the automatic identification of autonomic activations associated with cortical arousal. Sleep 2007; 30: 1349-61.
67. Davies RJO, Belt PJ, Roberts SJ, Ali NJ, Stradling JR. Arterial blood pressure responses to graded transient arousal from sleep in normal humans. J Appl Physiol 1993; 74: 1123-30.
68. Katz ES, Lutz J, Black C, Marcus CL. Pulse transit time as a measure of arousal and respiratory effort in children with sleep-disordered breathing. Pediat Res 2003; 53: 580-8.
69. Pepin JL, Delavie N, Pin I, Deschaux C, Argod J, Bost M, et al. Pulse transit time improves detection of sleep respiratory events and microarousals in children. Chest 2005;127: 722-30.
70. Lavie P, Shlitner A, Sheffy J, Schnall RP. Peripheral arterial tonometry: A novel and sensitive non-invasive monitor of brief arousals during sleep. Isr Med Assoc J 2000; 3: 246-7.
71. Lavie P, Schnall R P, Sheffy J, Shlitner, A. Peripheral vasoconstriction during REM sleep detected by a new plethysmographic method. Nat Med 2000; 6: 606.
72. Tauman R, O'Brien LM, Mast BT, Hodbrook CR, Gozal D. Peripheral arterial tonometry events and electroencephalographic arousals in children. Sleep 2004; 27: 502-6.
73. Karunajeewa AS, Cervena K, Adjivon B, Herrmann F, Abeyratne UR, Sforza E. Autonomic correlates of arousal from sleep in patients with sleep disorders. J Sleep Res 2006; 15 (suppl 1): A69, 33.
74. Horne JA. Sleep loss and "divergent" thinking ability. Sleep 1998; 11: 528-36.
75. Aldrich MS. Automobile accidents in patients with sleep disorders. Sleep 1989; 12: 487-494.
76. Stepanski EJ. The effect of sleep fragmentation on daytime function. Sleep 2002; 25: 268-76.
77. Engleman H, Joffe D. Neuropsychological function in obstructive sleep apnoea. Sleep Med Rev 1999; 3: 59-78.
78. Engleman H, Martin SE. Effects of continuous positive airway pressure treatment on daytime function in sleep apnoea/hypopnoea syndrome. Lancet 1994; 343: 572-5.
79. Wesensten NJ, Balkin TJ, Belenky G. Does sleep fragmentation impact recuperation? A review and reanalysis. J Sleep Res 1999;4: 237-45.
80. Adachi H, Mikami A, Kumano-Go T, Suganuma N, Matsumoto H, Shigedo Y, et al. Clinical significance of pulse rate rise during sleep as a screening marker for the assessment of sleep fragmentation in sleep-disordered breathing. Sleep Med 2003; 4: 537-42.
81. Winkelman JW, Shahar E, Sharief I, Gottlieb DJ. Association of restless leg syndrome and cardiovascular disease in the Sleep Heart Health Study. Neurology 2008; 70: 35-42.
82. Martin SE, Engleman HM, Kingshott RN, Douglas NJ. Microarousals in patients with sleep apnoea/hypopnoea syndrome. J Sleep Res 1997; 6: 276-80.
83. Guilleminault C, Abad VC, Philip P, Stoohs R. The effect of CNS activation versus EEG arousal during sleep on heart rate response and daytime tests. Clin Neurophysiol 2006; 117: 731-39.
84. Lombardi C, Parati G, Cortelli P, Provini F, Vetrugno R, Plazzi G, et al. Daytime sleepiness and neural cardiac modulation in sleep-related breathing disorders. J Sleep Res 2008; 17:263-70
85. Bennett LS, Barbour C, Langford B, Stradling JR, Davies RJ. Health status in obstructive sleep apnea: Relationship with sleep fragmentation and daytime sleepiness and effects of continuous positive airway pressure treatment. Am J Respir Crit Care Med 1999; 159: 1884-90.
86. Bonnet MH. Cognitive effects of sleep and sleep fragmentation. Sleep 1993; 16: 65-7.
87. Roche F, Celle S, Pichot V, Barthelemy JC, Sforza E. Analysis of the interbeat interval increment to detect obstructive sleep apnoea/ hypopnoea. Eur Respir J 2007; 29: 1206-11.
88. Stradling JR, Barbour C, Glennon J, Langford BA, Crosby JH. Prevalence of sleepiness and its relation to autonomic evidence of arousals and increased inspiratory effort in a community based population of men and women. J Sleep Res 2000; 4: 381-88.
89. Van Dongen HP, Maislin G, Mullington JM, Dinges DF. The cumulative cost of additional wakefulness: Dose-response effects on neurobehavioral functions and sleep physiology from chronic sleep restriction and total sleep deprivation. Sleep 2003; 26: 117-26.
90. Stepanski EJ. Sleep fragmentation, sleep deprivation or both. J Clin Sleep Med 2006; 2: 469.
91. Chaicharn J, Carrington M, Trinder J, Khoo MCK. The effects on cardiovascular autonomic control of repetitive arousal from sleep. Sleep 2008; 31: 93-103.