The effects of cilostazol on nerve conduction velocity and blood flow: Acute and chronic cauda equina compression in a canine model

Spine

Volumn 33, Issue 24, 2008, Pages 2605-2611

  Sekiguchi, Miho ^a   Aoki, Yoshihito ^a   Konno, Shin Ichi ^a   Kikuchi, Shin Ichi ^a  

^a FUKUSHIMA MEDICAL UNIVERSITY   (Japan)

Author keywords

Blood flow; Cauda equina; Cilostazol; Lumbar spinal stenosis; Nerve conduction velocity

Indexed keywords

CALCITONIN; CILOSTAZOL; PROSTAGLANDIN E1; ANTITHROMBOCYTIC AGENT; TETRAZOLE DERIVATIVE; VASODILATOR AGENT;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BLOOD CLOT; BLOOD FLOW; BLOOD VESSEL; CAPILLARY; CAUDA EQUINA; CELL PROTECTION; CONTROLLED STUDY; DRUG EFFICACY; DRUG MEGADOSE; ENDOTHELIUM CELL; EXPERIMENTAL DOG; INTERMITTENT CLAUDICATION; LOW DRUG DOSE; LUMBAR SPINE; NERVE COMPRESSION; NERVE CONDUCTION; NERVE ROOT; NONHUMAN; PRIORITY JOURNAL; THROMBOCYTE AGGREGATION INHIBITION; VASODILATATION; VERTEBRAL CANAL STENOSIS; ACTION POTENTIAL; ACUTE DISEASE; ANIMAL; BLOOD FLOW VELOCITY; CHRONIC DISEASE; DISEASE MODEL; DOG; DOSE RESPONSE; DRUG EFFECT; ELECTROSTIMULATION; INNERVATION; PATHOPHYSIOLOGY; SKELETAL MUSCLE; SPINAL CORD COMPRESSION; TIME; VASCULARIZATION;

ACTION POTENTIALS; ACUTE DISEASE; ANIMALS; BLOOD FLOW VELOCITY; CAUDA EQUINA; CHRONIC DISEASE; DISEASE MODELS, ANIMAL; DOGS; DOSE-RESPONSE RELATIONSHIP, DRUG; ELECTRIC STIMULATION; MUSCLE, SKELETAL; NEURAL CONDUCTION; PLATELET AGGREGATION INHIBITORS; REGIONAL BLOOD FLOW; SPINAL CORD COMPRESSION; TETRAZOLES; TIME FACTORS; VASODILATOR AGENTS;

EID: 58949099966     PISSN: 03622436     EISSN: 15281159     Source Type: Journal    
DOI: 10.1097/BRS.0b013e31818917e9     Document Type: Article

References (46)

1. Konno S, Olmarker K, Byröd G, et al. Intermittent cauda equina compression. An experimental study on the porcine cauda equina with analyses of nerve impulse conduction properties. Spine 1995;20:1223-6.
2. Takahashi K, Miyazaki T, Takino T, et al. Epidural pressure measurements. Relationship between epidural pressure and posture in patients with lumbar spinal stenosis. Spine 1995;20:650-3.
3. Joffe R, Appleby A, Arjona V. 'Intermittent ischaemia' of the cauda equina due to stenosis of the lumbar canal. J Neurol Neurosurg Psychiat 1966;29: 315-18.
4. Rydevik B, Holm S, Brown MD, et al. Diffusion from the cerebrospinal fluid as a nutritional pathway for spinal nerve roots. Acta Physiol Scnd 1990;138: 247-8.
5. Ooi Y, Mita F, Satoh Y. Myeloscopic study on lumbar spinal canal stenosis with special reference to intermittent claudication. Spine 1990;15:544-9.
6. Porter RW, Hibbert C. Calcitonin treatment for neurogenic claudication. Spine 1983;8:585-92.
7. Delamarter RB, Bohlman HH, Dodge LD, et al. Experimental lumbar spinal stenosis. Analysis of the cortical evoked potentials, microvasculature and histopathology. J Bone Joint Surg 1990;72:110-20.
8. Konno S, Sato K, Yabuki S, et al. A model for acute, chronic and delayed, graded compression. Presentation of gross, microscopic, and vascular anatomy and accuracy in pressure transmission of the compression model. Spine 1995;20:2758-64.
9. Sato K, Konno S, Yabuki S, et al. A model for acute, chronic, and delayed graded compression of the dog cauda eqina. Neurophysiological and histologic changes induced by acute, graded compression. Spine 1995;20: 2386-91.
10. Olmarker K, Rydevik B, Holm S, et al. Effects of experimental graded compression blood flow in spinal nerve roots. A vital microscopic study on the porcine cauda equina. J Orthop Res 1989;7:817-23.
11. Olmarker K, Rydevik B, Hansson T, et al. Compression-induced changes of the nutritional supply to the porcine cauda. J Spinal Dis 1990;1:25-9.
12. Rydevik BL, Pedowitz RA, Hargens AR, et al. Effects of acute graded compression on spinal nerve root function and structure: an experimental study on the pig cauda equina. Spine 1991;16:487-93.
13. Otani K,Kikuchi S,Konno S, etal. Blood flow measurement on experimental chronic cauda equina compression in dogs: changes in blood flow at various conditions. J Spinal Disord 2001;14:343-6.
14. IwamotoH,Kuwahara H, MatsudaH, et al. Production ofchronic compression of the cauda equina in rats for use in studies of lumbar spinal canal stenosis. Spine 1995;20:2750 -7.
15. Iwamoto H, Matsuda H, Noriage A, et al. Lumbar spinal canal stenosis experimental electrophysiologically in a rat model of chronic cauda equina compression. Spine 1997;22:2636-40.
16. Watanabe K, Konno S, Sekiguchi M, et al. Spinal stenosis: assessment of motor function, VEGF expression and angiogenesis in an experimental model in the rat. Eur Spine J 2007;16:1913-8.
17. Yonetake T, Sekiguchi M, Konno S, et al. Compensatory neovascularization after cauda equina compression in rats. Spine 2008;15:140-5.
18. Sekiguchi M, Konno S, Anzai H, et al. Nerve vasculature changes induced by serotonin under chronic cauda equina compression. Spine 2002;27:1634-9.
19. Kamiya T, Sakaguchi S. Hemodynamic effects of the antithrombotic drug cilostazol in chronic arterial occlusion in the extremities. Arzneimittelforschung 1985;35:1201-1203.
20. Kawamura K, Watanabe K, Kimura Y. Effect of cilostazol, a new antithrom-botic drug, on cerebral circulation. Arzneimittelforschung 1985;35: 1149-54.
21. Kihara M, Schmelzer JD, Low PA. Effect of cilostazol on experimental diabetic neuropathy in the rat. Diabetologia 1995;38:914-18.
22. Money SR, Herd JA, Isaacsohn JL, et al. Effect of cilostazol on walking distances in patients with intermittent claudication caused by peripheral vascular disease. J Vasc Surg 1998;27:267-74.
23. Murakami M, Takahashi K, Sekikawa T, et al. Effects of intravenous li-poprostaglandin E1 on neurogenic intermittent claudication. J Spinal Disord 1997;10:499-504.
24. Kikuchi S, Konno S, Kayama S, et al. Increased resistance to acute compression injury in chronically compressed spinal nerve roots: an experimental study. Spine 1996;21:2544-50.
25. Mao GP, Konno S, Arai I, et al. Chronic double-level cauda equina compression. An experimental study on the dog cauda equina with analyses of nerve conduction velocity. Spine 1998;23:1641-4.
26. Otani K, Kayama S, Mao GP, et al. Tolerance to acute compression injury and recovert of nerve function in chronically compressed spinal nerve roots: experimental study. J Orthop Sci 1997;2:226-70.
27. Richardson KC, Jarett L, Finke EH. Embedding in epoxy resins for ultrathin sectioning in electron microscopy. Stain Technol 1960;34:313-23.
28. Konno S, Kayama S, Kikuchi S. Effects of OP-1206 (prostaglandin E1) on nerve conduction velocity in the dog cauda equina subjected to acute experimental compression. J Spinal Disord 1996;9:103-6.
29. Konno S, Arai I, Otani K, at el. Effects of beraprost sodium on canine cauda equina function and blood flow using a chronic spinal cord compression model. J Spinal Disord 2001;14:336-8.
30. Yone K, Sakou T, Kawaguchi Y. The effect of Lipo prostaglandin E1 on cauda equina blood flow in patients with lumbar spinal canal stenosis: myeloscopic observation. Spinal Cord 1999;37:269-74.
31. Sekiguchi M, Konno S, Kikuchi S. Effects on improvement of blood flow in the chronically compressed cauda equina. Comparison between a selective prostaglandin E receptor (EP4) agonist and a prostaglandin E1 derivate. Spine 2006;31:869-72.
32. Sekiguchi M, Konno S, Kikuchi S. Effects of 5-Ht2A receptor antagonist on blood flowinchronically compressed nerve roots. J Peripher Nerv Syst 2004; 9:263-9.
33. Olmarker K, Rydevik B, Holm S. Edema formation in spinal nerve roots induced byexperimental, graded compression. An experimental study onthe pig cauda equina with special reference to differences in effects between rapid and slow onset to compression. Spine 1989;14:569-73.
34. Okuda Y, Mizutani M, Ikegami T, et al. Hemodynamic effects of cilostazol on peripheral artery in patients with diabetic neuropathy. Arzneimittelforschung 1992;42:540-2.
35. Norgren L, Hiatt WR, Dormandy JA, et al. Inter-society consensus for the management of peripheral arterial disease TASCII). Eur J Endovasc Surg 2007;33:S1-70.
36. Olmarker K, Holm S, Rosenqvist AL, et al. Experimental nerve root compression. Presentation of a model for acute, graded compression injury of the porcine cauda equina, with analyses of the normal nerve and vascular anatomy. Spine 1991;16:61-9.
37. Olmarker K, Lind B, Holm S, et al. Continued compression increase impairment of impulse propagation in experimental compression of the porcine cauda equina. Neuro Orthopaedics 1991;11:75-81.
38. Kobayashi S, Yoshizawa H, Yamada S. Pathology of lumbar nerve root compression. Part 1: Intraradicular inflammatory changes induced by mechanical compression. J Orthop Res 2004;22:170-9.
39. Houston DS, Vanhoutte PM. Serotonin and the vascular system. Role in health and disease, and implications for therapy. Drugs 1986;31:146-63.
40. Vanhoutte PM, Luscher TF. Serotonin and the blood vessel wall. J Hypertens Suppl 1986;4:S29-35.
41. Kim KY, Shin HK, Chio JM, et al. Inhibition of lipopolysaccharide-induced apoptosis by cilostazol in human umbilical vein endothelial cells. J Pharmacol Exp Ther 2002;300:709-15.
42. Hong KW, Kim KY, Shin HK, et al. Cilostazol prevents tumor necrosis factor-alpha induced cell death by suppression of phosphatase and tensin homolog of Akt/cyclic AMP response element-binding protein phosphoryla-tion. J Pharmacol Exp Ther 2003;306:1182-90.
43. Otani K, Arai I, Mao GP, et al. Experimental disc herniation: evaluation of the natural course. Spine 1997;22:2894-9.
44. Ito T, Ohtori S, Hta K, et al. Rho kinase inhibitor improves motor dysfunction and hypoalgesia in a rat model of lumbar spinal canal stenosis. Spine 2007;32:1070-5.
45. Yamaguchi K, Murakami M, Takahashi K, et al. Behavioral and morphologic studies of the chronically compressed cauda eqina. Spine 1999;24: 845-51.
46. Nakai K, Takenobu Y, Eguchi K, et al. The effects of OP1206alpha-CD on walking dysfunction in the rat neuropathic intermittent claudication model. Anesth Analg 2002;94:1537-41.