Oral antibiotics in the management of serious neonatal bacterial infections in developing country communities

Pediatric Infectious Disease Journal

Volumn 28, Issue SUPPL. 1, 2009, Pages

  Darmstadt, Gary L ^a,d   Batra, Maneesh ^b   Zaidi, Anita K M ^c  

^a JOHNS HOPKINS BLOOMBERG SCHOOL OF PUBLIC HEALTH   (United States)

^b UNIVERSITY OF WASHINGTON SCHOOL OF MEDICINE   (United States)

^c AGA KHAN UNIVERSITY   (Pakistan)

^d BILL AND MELINDA GATES FOUNDATION   (United States)

Author keywords

Developing country; Home based treatment; Neonatal sepsis; Oral antibiotics; Serious bacterial infections

Indexed keywords

AMIKACIN; AMOXICILLIN; AMOXICILLIN PLUS CLAVULANIC ACID; AMPICILLIN; ANTIBIOTIC AGENT; CEFADROXIL; CEFALEXIN; CEFIXIME; CEFPROZIL; CEFUROXIME; CEPHALOSPORIN DERIVATIVE; CIPROFLOXACIN; COTRIMOXAZOLE; ERYTHROMYCIN; GENTAMICIN; PENICILLIN G; PROCAINE PENICILLIN; ANTIINFECTIVE AGENT;

ABSENCE OF SIDE EFFECTS; ANTIBIOTIC SENSITIVITY; ANTIBIOTIC THERAPY; BACTERIAL INFECTION; BACTERIAL PNEUMONIA; CHONDROPATHY; CLINICAL TRIAL; COMBINATION CHEMOTHERAPY; COMMUNITY ACQUIRED PNEUMONIA; DEVELOPING COUNTRY; DRUG ABSORPTION; DRUG BIOAVAILABILITY; DRUG BLOOD LEVEL; DRUG COST; DRUG PENETRATION; DRUG SAFETY; DRUG SUBSTITUTION; DRUG WITHDRAWAL; GRAM NEGATIVE INFECTION; GROUP B STREPTOCOCCAL INFECTION; HEALTH CARE ACCESS; HEALTH EDUCATION; HOME CARE; HOSPITAL CARE; HUMAN; IMMUNIZATION; JAUNDICE; MEDICAL ETHICS; MONOTHERAPY; NECROTIZING ENTEROCOLITIS; NEWBORN CARE; NEWBORN INFECTION; NEWBORN MORTALITY; NEWBORN SEPSIS; NONHUMAN; OUTPATIENT CARE; PRIORITY JOURNAL; REVIEW; RISK REDUCTION; STAPHYLOCOCCUS AUREUS; STREPTOCOCCUS PYOGENES; TREATMENT DURATION; TREATMENT RESPONSE; COMMUNITY CARE; ETHICS; NEWBORN; ORAL DRUG ADMINISTRATION;

ADMINISTRATION, ORAL; ANTI-BACTERIAL AGENTS; BACTERIAL INFECTIONS; COMMUNITY HEALTH SERVICES; DEVELOPING COUNTRIES; HUMANS; INFANT, NEWBORN;

EID: 58949097123     PISSN: 08913668     EISSN: 15320987     Source Type: Journal    
DOI: 10.1097/INF.0b013e3181958794     Document Type: Article

References (59)

1. Stoll BJ. The global impact of neonatal infection. Clin Perinatol. 1997;24: 1-21.
2. Osrin D, Vergnano S, Costello A. Serious bacterial infections in newborn infants in developing countries. Curr Opin Infect Dis. 2004;17:217-224.
3. Stoll BJ. Neonatal infections: a global perspective. In: Remington JS, Klein JO, eds. Infectious Diseases of the Fetus and Newborn Infant. 6th ed. Philadelphia,PA: WB Saunders; 2005:27-57.
4. Zaidi AK, Huskins WC, Thaver D, et al. Hospital-acquired neonatal infections in developing countries. Lancet. 2005;365:1175-1188.
5. World Health Organization Management of the sick newborn. Report of a Technical Working Group, Ankara June 5-8, 1995. Geneva: World Health Organization; 1996. WHO/FRH/MSM/96.12.
6. Darmstadt GL, Baqui AH, Choi Y, et al. Validation of community health workers' assessment of neonatal illness in rural Bangladesh. Bull WHO. In press.
7. Baqui AH, Arifeen SE, Williams EM, et al. Effectiveness of home-based management of newborn infections by community health workers in rural Bangladesh. Pediatr Infect Dis J. In press.
8. Baqui AH, Arifeen SE, Darmstadt GL, et al. Effect of a package of community- based newborn care delivered by two strategies in Sylhet district, Bangladesh: a cluster-randomised controlled trial. Lancet. 2008;371:1936- 1944.
9. Bang AT, Bang RA, Baitule SB, et al. Effect of home-based neonatal care and management of sepsis on neonatal mortality: field trial in rural India. Lancet. 1999;354:1955-1961.
10. World Health Organization. Programme of Acute Respiratory Infections. Report of the Fourth Meeting of Technical Advisory Group 6-10 March 1989. Geneva: World Health Organization; 1989.
11. World Health Organization. Acute Respiratory Infections In Children: Case Management In Hospitals In Developing Countries.Geneva: World Health Organization; 1990.
12. Datta N, Kumar V, Kumar L, et al. Application of case management to the control of acute respiratory infections in low-birth-weight infants: a feasibility study. Bull World Health Organ. 1987;65:77- 82.
13. de Zoysa I, Bhandari N, Akhtari N, et al. Careseeking for illness in young infants in an urban slum in India. Soc Sci Med. 1998;47:2101-2111.
14. Ahmed S, Sobhan F, Islam A, et al. Neonatal morbidity and care-seeking behaviour in rural Bangladesh. J Trop Pediatr. 2001;47:98 -105.
15. Willis JR, Kumar V, Mohanty S, et al. Gender differences in care-seeking for newborn infants in rural Uttar Pradesh, India. J Health Pop Nutr. In press.
16. Bang AT, Bang RA, Stoll BJ, et al. Is home-based diagnosis and treatment of neonatal sepsis feasible and effective? Seven years of intervention in the Gadchiroli field trial (1996 to 2003). J Perinatol. 2005;25(suppl 1):S62-S71.
17. Bang AT, Bang RA, Sontakke PG. Management of childhood pneumonia by traditional birth attendants. The SEARCH Team. Bull World Health Organ. 1994;72:897-905.
18. Bang RA, Bang AT, Baitule M, et al. High prevalence of gynaecological diseases in rural Indian women. Lancet. 1989;1:85- 88.
19. Bang AT, Bang RA, Morankar VP, et al. Pneumonia in neonates: can it be managed in the community? Arch Dis Child. 1993;68:550 -556.
20. Darmstadt GL, Batra M. Parenteral antibiotics for the treatment of serious neonatal bacterial infections in developing country settings. Pediatr Infect Dis J. In press.
21. Heimann G. Enteral absorption and bioavailability in children in relation to age. Eur J Clin Pharmacol. 1980;18:43-50.
22. Bartlett AV, Paz de Bocaletti ME, Bocaletti MA. Neonatal and early postneonatal morbidity and mortality in a rural Guatemalan community: the importance of infectious diseases and their management. Pediatr Infect Dis J. 1991;10:752-757.
23. Bhandari N, Bahl R, Bhatnagar V, et al. Treating sick young infants in urban slum setting. Lancet. 1996;347:1774 -1775.
24. Zaidi AK, Sundar S, Darmstadt GL, et al. Antibiotic therapy for serious bacterial infections in young infants: randomized community-based trial. Paper presented at: Pediatric Academic Societies' Annual Meeting; 2006; San Francisco, CA.
25. Sazawal S, Black RE. Meta-analysis of intervention trials on case-management of pneumonia in community settings. Lancet. 1992;340:528 -533.
26. Sazawal S, Black RE. Effect of pneumonia case management on mortality in neonates, infants, and preschool children: a meta-analysis of communitybased trials. Lancet Infect Dis. 2003;3:547-556.
27. Khan AJ, Khan JA, Akbar M, et al. Acute respiratory infections in children: a case management intervention in Abbottabad District, Pakistan. Bull World Health Organ. 1990;68:577-585.
28. Khan JA. Case-management of acute respiratory infection in children of Abbottabad District, Pakistan: an intervention study. Bull Int Union Tuberc Lung Dis. 1990;65(4):25-28.
29. Kielmann AA, Taylor CE, DeSweemer C, et al. The Narangwal experiment on interactions of nutrition and infections : II. Morbidity and mortality effects. Indian J Med Res. 1978;68(suppl):21- 41.
30. Mtango FD, Neuvians D. Acute respiratory infections in children under five years. Control project in Bagamoyo District, Tanzania. Trans R Soc Trop Med Hyg. 1986;80:851- 858.
31. Bang AT, Bang RA, Tale O, et al. Reduction in pneumonia mortality and total childhood mortality by means of community-based intervention trial in Gadchiroli, India. Lancet. 1990;336:201-206.
32. Pandey MR, Daulaire NM, Starbuck ES, et al. Reduction in total under-five mortality in western Nepal through community-based antimicrobial treatment of pneumonia. Lancet. 1991;338:993-997.
33. Fauveau V, Stewart MK, Chakraborty J, et al. Impact on mortality of a community-based programme to control acute lower respiratory tract infections. Bull World Health Organ. 1992;70:109 -116.
34. Lawn JE, Cousens S, Zupan J. 4 million neonatal deaths: When? Where? Why? Lancet. 2005;365:891-900.
35. Saving Newborn Lives. State of the World's Newborns, Washington, DC: Save the Children Federation; 2001.
36. Sutrisna B, Frerichs RR, Reingold AL. Randomised, controlled trial of effectiveness of ampicillin in mild acute respiratory infections in Indonesian children. Lancet. 1991;338:471- 474.
37. Pandey MR, Sharma PR, Gubhaju BB, et al. Impact of a pilot acute respiratory infection (ARI) control programme in a rural community of the hill region of Nepal. Ann Trop Paediatr. 1989;9:212-220.
38. World Health Organization. The Management of Acute Respiratory Infections In Children: Practical Guidelines for Outpatient Care.Geneva: World Health Organization; 1995.
39. Darmstadt GL. Oral antibiotic therapy for uncomplicated bacterial skin infections in children. Pediatr Infect Dis J. 1997;16:227-240.
40. Darmstadt GL. Antibiotics in the management of pediatric skin disease. Dermatol Clin. 1998;16:509 -525.
41. Honein MA, Paulozzi LJ, Himelright IM, et al. Infantile hypertrophic pyloric stenosis after pertussis prophylaxis with erythromcyin: a case review and cohort study. Lancet. 1999;354:2101-2105.
42. Conclusions from the WHO multicenter study of serious infections in young infants. The WHO Young Infants Study Group. Pediatr Infect Dis J. 1999; 18(10 suppl):S32-S34.
43. Saha SK, Rikitomi N, Ruhulamin M, et al. Antimicrobial resistance and serotype distribution of Streptococcus pneumoniae strains causing childhood infections in Bangladesh, 1993 to 1997. J Clin Microbiol. 1999;37:798-800.
44. Straus WL, Qazi SA, Kundi Z, et al. Antimicrobial resistance and clinical effectiveness of co-trimoxazole versus amoxicillin for pneumonia among children in Pakistan: a randomized controlled trial. Lancet. 352:270 -274.
45. Montanari MP, Cochetti I, Mingoia M, et al. Phenotypic and molecular characaterization of tetracycline- and erythromycin-resistant strains of Streptococcus pneumonia Antimicrob Agents Chemother. 2003;47:2236 - 2241.
46. Adam D. Use of quinolones in pediatric patients. Rev Infect Dis. 1989; 11(suppl 5):S1113-S1116.
47. Ahmed AS, Khan NZ, Saha SK, et al. Ciprofloxacin treatment in preterm neonates in Bangladesh: lack of effects on growth and development. Pediatr Infect Dis J. 2006;25:1137-1141.
48. Dutta S, Chowdhary G, Kumar P, et al. Ciprofloxacin administration to very low birth weight babies has no effect on linear growth in infancy. J Trop Pediatr. 2006;52:103-106.
49. Drossou-Agakidou V, Roilides E, Papakyriakidou-Koliouska P, et al. Use of ciprofloxacin in neonatal sepsis: lack of adverse effects up to one year. Pediatr Infect Dis J. 2004;23:346 -349.
50. Chaudhari S, Suryawanshi P, Ambardekar S, et al. Safety profile of ciprofloxacin used for neonatal septicemia. Indian Pediatr. 2004;41: 1246 -1251.
51. Cohen MD, Raeburn JA, Devine J, et al. Pharmacology of some oral penicillins in the newborn infant. Arch Dis Child. 1975;50:230 -234.
52. Gras-Le Guen C, Boscher C, Godon N, et al. Therapeutic amoxicillin levels achieved with oral administration in term neonates. Eur J Clin Pharmacol. 2007;63:657- 662.
53. Kenyon SL, Taylor DJ, Tarnow-Mordi W. Broad-spectrum antibiotics for preterm, prelabour rupture of fetal membranes: the ORACLE I randomised trial. ORACLE Collaborative Group. Lancet. 2001;357:979 -988.
54. Kenyon SL, Taylor DJ, Tarnow-Mordi W. Broad-spectrum antibiotics for spontaneous preterm labour: the ORACLE II randomised trial. ORACLE Collaborative Group. Lancet. 2001;357:989 -994.
55. Winch PJ, Alam MA, Akther A, et al. Local understandings of vulnerability and protection during the neonatal period in Sylhet District, Bangladesh: a qualitative study. Lancet. 2005;366:478-485.
56. Darmstadt GL, Black RE, Santosham M. Research priorities and postpartum care strategies for the prevention and optimal management of neonatal infections in less developed countries. Pediatr Infect Dis J. 2000; 19:739 -750.
57. Bang AT, Bang RA, Baitule S, et al. Burden of morbidities and the unmet need for health care in rural neonates-a prospective observational study in Gadchiroli, India. Indian Pediatr. 2001;38:952-965.
58. Emanuel EJ, Wendler D, Killen J, et al. What makes clinical research in developing countries ethical? The benchmarks of ethical research. J Infect Dis. 2004;189:930 -937.
59. Kuritzkes DR. Ethical conduct of research in resource-limited settings. J Infect Dis. 2004;189:764 -765.