Application of a liquid chromatography/tandem mass spectrometry method for the pharmacokinetic study of dihydroartemisinin injectable powder in healthy Chinese subjects

Journal of Chromatography B: Analytical Technologies in the Biomedical and Life Sciences

Volumn 877, Issue 5-6, 2009, Pages 465-470

  Liu, Yiming ^a   Zeng, Xing ^a   Deng, Yuanhui ^a   Wang, Lu ^b   Feng, Yi ^a   Yang, Liu ^a   Zhou, Dan ^a  

^a GUANGDONG PROVINCIAL HOSPITAL OF CHINESE MEDICINE   (China)

^b Beijing Huali Ketai Pharmaceutical Co Ltd   (China)

Author keywords

Dihydroartemisinin; Human plasma; Injectable powder; LC MS MS; Pharmacokinetics

Indexed keywords

AMMONIUM COMPOUNDS; CHROMATOGRAPHIC ANALYSIS; ELECTROSPRAY IONIZATION; ESTERS; EXTRACTION; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HIGH PRESSURE LIQUID CHROMATOGRAPHY; LIQUID CHROMATOGRAPHY; MASS SPECTROMETERS; MASS SPECTROMETRY; METHANOL; PHARMACOKINETICS; PLASMA (HUMAN); PLASMAS; POWDERS; SOLVENT EXTRACTION; SPECTROMETERS; SPECTROMETRY; SPECTRUM ANALYSIS;

AMMONIUM ACETATES; ANALYTE; DIHYDROARTEMISININ; DOSE RANGES; ELECTROSPRAY IONIZATION-TANDEM MASS SPECTROMETRIES; ETHYL ACETATES; HEALTHY SUBJECTS; HUMAN PLASMA; INJECTABLE POWDER; ISOCRATIC ELUTIONS; LC/MS/MS; LINEAR DYNAMICS; LIQUID CHROMATOGRAPHY/TANDEM MASS SPECTROMETRIES; LIQUID-LIQUID EXTRACTIONS; METHANOL WATERS; PHARMACOKINETIC STUDIES; SINGLE STEPS;

IONIZATION OF LIQUIDS;

ACETIC ACID ETHYL ESTER; AMMONIUM ACETATE; DIHYDROARTEMISININ; METHANOL;

ACCURACY; ADULT; AREA UNDER THE CURVE; ARTICLE; CHINESE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; DRUG BLOOD LEVEL; DRUG DETERMINATION; DRUG ELIMINATION; DRUG HALF LIFE; DRUG ISOLATION; DRUG STRUCTURE; ELECTROSPRAY MASS SPECTROMETRY; ELUTION; FEMALE; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; INJECTION; LIQUID LIQUID EXTRACTION; MALE; NORMAL HUMAN; POWDER; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; SINGLE DRUG DOSE; TANDEM MASS SPECTROMETRY; VALIDATION STUDY;

ADULT; ANTIMALARIALS; ARTEMISININS; ASIAN CONTINENTAL ANCESTRY GROUP; CALIBRATION; CHINA; CHROMATOGRAPHY, LIQUID; DRUG STABILITY; FEMALE; HEALTH; HUMANS; INFUSIONS, INTRAVENOUS; INJECTIONS; MALE; POWDERS; REPRODUCIBILITY OF RESULTS; TANDEM MASS SPECTROMETRY; TIME FACTORS;

EID: 58949091239     PISSN: 15700232     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jchromb.2008.11.039     Document Type: Article

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