Inhibition of rat liver cathepsins B and L by the peptide aldehyde benzyloxycarbonyl-leucyl-leucyl-leucinal and its analogues

Journal of Enzyme Inhibition and Medicinal Chemistry

Volumn 24, Issue 1, 2009, Pages 279-286

  Ito, Hisashi ^a   Watanabe, Masafumi ^a   Kim, Yong Tae ^a,b   Takahashi, Kenji ^c  

^a AOYAMA GAKUIN UNIVERSITY   (Japan)

^b RIKEN YOKOHAMA INSTITUTE   (Japan)

^c TOKYO UNIVERSITY OF PHARMACY AND LIFE SCIENCES   (Japan)

Author keywords

Cathepsin B; Cathepsin L; Cysteine protease inhibitor; IC50; Inhibition; Peptide aldehyde

Indexed keywords

2 FURANCARBONYLLEUCYLLEUCYLLEUCINAL; 4 MORPHOLINYLSUCCINYLLEUCYLLEUCYLLEUCINAL; ACETYLPROLYLLEUCYLLEUCYLLEUCINAL; ACETYLPROLYLPROLYLLEUCYLLEUCYLLEUCINAL; BENZYLOXYCARBONYLLEUCYLLEUCYLLEUCINAL; CATHEPSIN B; CATHEPSIN L; CYSTEINE PROTEINASE; ISONICOTINYLLEUCYLLEUCYLLEUCINAL; NICOTINYLLEUCYLLEUCYLLEUCINAL; PAPAIN; PROTEINASE INHIBITOR; UNCLASSIFIED DRUG;

ANIMAL TISSUE; AQUEOUS SOLUTION; ARTICLE; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; DRUG PURIFICATION; DRUG STABILITY; DRUG STRUCTURE; DRUG SYNTHESIS; ENZYME INHIBITION; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; MOLECULAR WEIGHT; NONHUMAN; PRIORITY JOURNAL; PROTEIN FAMILY; RAT;

ANIMALS; CATHEPSIN B; CATHEPSINS; CYSTEINE ENDOPEPTIDASES; DOSE-RESPONSE RELATIONSHIP, DRUG; INHIBITORY CONCENTRATION 50; LEUPEPTINS; RATS;

RATTUS;

EID: 58949086774     PISSN: 14756366     EISSN: 14756374     Source Type: Journal    
DOI: 10.1080/14756360802166921     Document Type: Article

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