Synthesis and evaluation of benzophenone oximes derivatized with sydnone as inhibitors of secretory phospholipase A2 with anti-inflammatory activity

Chemical and Pharmaceutical Bulletin

Volumn 57, Issue 1, 2009, Pages 16-21

  Kamble, Ravindra Ramappa ^a   Belgur, Sudha Sathyanarayanrao ^b   Aladkatti, Ravindranath ^c   Khazi, Imthiyaz Ahmed ^a  

^a KARNATAK UNIVERSITY   (India)

^b UNIVERSITY OF MYSORE   (India)

^c INDIAN INSTITUTE OF SCIENCE   (India)

Author keywords

Benzophenone oxime; Nonsteroidal anti inflammatory drug; Phospholipase A 2; Sydnone; Synthesis

Indexed keywords

3 [4 [HYDROXYIMINO (4'' N BUTYLPHENYL)METHYL]PHENYL] 4 PHENYL SYDNONE; 3 [4 [HYDROXYIMINO (4'' N BUTYLPHENYL)METHYL]PHENYL]SYDNONE; 3 [4 [HYDROXYIMINO (4'' N PROPYLPHENYL)METHYL]PHENYL] 4 PHENYL SYDNONE; 3 [4 [HYDROXYIMINO (4'' N PROPYLPHENYL)METHYL]PHENYL]SYDNONE; 3 [4' (HYDROXYIMINO 4 TOLYLMETHYL) HENYL] 4 PHENYL SYDNONE; 3 [4' (HYDROXYIMINO 4 TOLYLMETHYL)PHENYL]SYDNONE; 3 [4' (HYDROXYIMINOPHENYLMETHYL)PHENYL] 4 PHENYL SYDNONE; 3 [4' (HYDROXYIMINOPHENYLMETHYL)PHENYL]SYDNONE; ANTIINFLAMMATORY AGENT; BENZOPHENONE DERIVATIVE; CARBON 14; CYCLOOXYGENASE 2; OLEIC ACID; OXIME DERIVATIVE; PHOSPHOLIPASE A2 INHIBITOR; SECRETORY PHOSPHOLIPASE A2; SNAKE VENOM; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIINFLAMMATORY ACTIVITY; ARTICLE; ASCITES FLUID; CHEMICAL STRUCTURE; CONTROLLED STUDY; DERIVATIZATION; DOSE RESPONSE; EDEMA; ENZYME INHIBITION; ENZYME SPECIFICITY; ENZYME SUBSTRATE; HEMOLYSIS; HUMAN; HUMAN CELL; IN VITRO STUDY; IN VIVO STUDY; ISOTOPE LABELING; MOUSE; NONHUMAN; PLEURA FLUID; PROTON NUCLEAR MAGNETIC RESONANCE; STRUCTURE ACTIVITY RELATION; SYNTHESIS;

ANIMALS; ANTI-INFLAMMATORY AGENTS; BENZOPHENONES; DOSE-RESPONSE RELATIONSHIP, DRUG; ENZYME INHIBITORS; MICE; MOLECULAR STRUCTURE; OXIMES; PHOSPHOLIPASES A2; STRUCTURE-ACTIVITY RELATIONSHIP; SYDNONES;

EID: 58849159754     PISSN: 00092363     EISSN: 13475223     Source Type: Journal    
DOI: 10.1248/cpb.57.16     Document Type: Article

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