Rickettsiae stimulate dendritic cells through toll-like receptor 4, leading to enhanced NK cell activation in vivo

Journal of Infectious Diseases

Volumn 199, Issue 2, 2009, Pages 236-242

  Jordan, Jeffrey M ^a   Woods, Michael E ^a   Soong, Lynn ^a   Walker, David H ^a,b  

^a University of Texas Medical Branch School of Medicine   (United States)

^b UNIVERSITY OF TEXAS MEDICAL BRANCH   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

GAMMA INTERFERON; TOLL LIKE RECEPTOR 4;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BACTERIAL GROWTH; BOUTONNEUSE FEVER; CELL ACTIVATION; CELL ACTIVITY; CELL EXPANSION; CELL FUNCTION; CELL POPULATION; CYTOKINE PRODUCTION; CYTOTOXICITY; DENDRITIC CELL; FLOW CYTOMETRY; IMMUNITY; IN VIVO STUDY; MALE; MOUSE; NATURAL KILLER CELL; NONHUMAN; PRIORITY JOURNAL; PROTEIN FUNCTION; RICKETTSIA;

ANIMALS; BRAIN; DENDRITIC CELLS; ENDOTHELIUM, VASCULAR; IMMUNITY, INNATE; INTERFERON-GAMMA; KILLER CELLS, NATURAL; LYMPHOCYTE ACTIVATION; MALE; MICE; MICE, INBRED C3H; RICKETTSIA CONORII; RICKETTSIA INFECTIONS; TOLL-LIKE RECEPTOR 4;

EID: 58849133848     PISSN: 00221899     EISSN: None     Source Type: Journal    
DOI: 10.1086/595833     Document Type: Article

References (32)

1. Fernandez NC, Lozier A, Flament C, et al. Dendritic cells directly trigger NK cell functions: cross-talk relevant in innate anti-tumor immune responses in vivo. Nat Med 1999; 5:405-11.
2. Granucci F, Feau S, Angeli V, Trottein F, Ricciardi-Castagnoli P. Early IL-2 production by mouse dendritic cells is the result of microbial-induced priming. J Immunol 2003; 170:5075-81.
3. Granucci F, Feau S, Zanoni I, et al. The immune response is initiated by dendritic cells via interaction with microorganisms and interleukin-2 production. J Infect Dis 2003; 187(Suppl 2):S346-50.
4. Alli RS, Khar A. Interleukin-12 secreted by mature dendritic cells mediates activation of NK cell function. FEBS Lett 2004; 559:71-6.
5. Granucci F, Zanoni I, Pavelka N, et al. A contribution of mouse dendritic cell-derived IL-2 for NK cell activation. J Exp Med 2004; 200:287-95.
6. Jordan JM, Woods ME, Feng HM, Soong L, Walker DH. Rickettsiae-stimulated dendritic cells mediate protection against lethal rickettsial challenge in an animal model of spotted fever rickettsiosis. J Infect Dis 2007;196:629- 38.
7. Feng H, Popov VL, Yuoh G, Walker DH. Role of T lymphocyte subsets in immunity to spotted fever group rickettsiae. J Immunol 1997; 158:5314-20.
8. Feng HM, Popov VL, Walker DH. Depletion of gamma interferon and tumor necrosis factor alpha in mice with Rickettsia conorii-infected endothelium: impairment of rickettsicidal nitric oxide production resulting in fatal, overwhelming rickettsial disease. Infect Immun 1994; 62:1952-60.
9. Le-Barillec K, Magalhaes JG, Corcuff E, et al. Roles for T and NK cells in the innate immune response to Shigella flexneri. J Immunol 2005; 175:1735-40.
10. Carl M, Martin EE, Dasch GA. Human T helper cells specific for antigens of typhus group rickettsiae enhance natural killer cell activity in vitro. Infect Immun 1986; 54:297-302.
11. Billings AN, Feng HM, Olano JP, Walker DH. Rickettsial infection in murine models activates an early anti-rickettsial effect mediated by NK cells and associated with production of gamma interferon. Am J Trop Med Hyg 2001; 65:52-6.
12. Brattig NW, Bazzocchi C, Kirschning CJ, et al. The major surface protein of Wolbachia endosymbionts in filarial nematodes elicits immune responses through TLR2 and TLR4. J Immunol 2004; 173:437-45.
13. Damas JK, Jensenius M, Ueland T, et al. Increased levels of soluble CD40L in African tick bite fever: possible involvement of TLRs in the pathogenic interaction between Rickettsia africae, endothelial cells, and platelets. J Immunol 2006; 177:2699-706.
14. Tsujimoto H, Uchida T, Efron PA, et al. Flagellin enhances NK cell proliferation and activation directly and through dendritic cell-NK cell interactions. J Leukoc Biol 2005; 78:888-97.
15. Krug A, French AR, Barchet W, et al. TLR9-dependent recognition of MCMV by IPC and DC generates coordinated cytokine responses that activate antiviral NK cell function. Immunity 2004; 21:107-19.
16. Andoniou CE, Van Dommelen SL, Voigt V, et al. Interaction between conventional dendritic cells and natural killer cells is integral to the activation of effective antiviral immunity. Nat Immunol 2005; 6:1011-9.
17. Schleicher U, Liese J, Knippertz I, et al. NK cell activation in visceral leishmaniasis requires TLR9, myeloid DCs, and IL-12, but is independent of plasmacytoid DCs. J Exp Med 2007; 204:893-906.
18. Hoshino K, Takeuchi O, Kawai T, et al. Cutting edge: Toll-like receptor 4 (TLR4)-deficient mice are hyporesponsive to lipopolysaccharide: evidence for TLR4 as the Lps gene product. J Immunol 1999; 162:3749-52.
19. Poltorak A, He X, Smirnova I, et al. Defective LPS signaling in C3H/HeJ and C57BL/10ScCr mice: mutations in Tlr4 gene. Science 1998; 282:2085-8.
20. Qureshi ST, Lariviere L, Leveque G, et al. Endotoxin-tolerant mice have mutations in Toll-like receptor 4 (Tlr4). J Exp Med 1999; 189:615-25.
21. Jordan JM, Woods ME, Olano JP, Walker DH. Absence of TLR4 signaling in C3H/HeJ mice predisposes to overwhelming rickettsial infection and decreased protective Th1 responses. Infect Immun 2008; 76:3717-24.
22. Hanson BA, Wisseman CL Jr, Waddell A, Silverman DJ. Some characteristics of heavy and light bands of Rickettsia prowazekii on Renografin gradients. Infect Immun 1981; 34:596-604.
23. Song L, Pachter JS. Culture of murine brain microvascular endothelial cells that maintain expression and cytoskeletal association of tight junction-associated proteins. In Vitro Cell Dev Biol Anim 2003; 39:313-20.
24. Perriere N, Demeuse P, Garcia E, et al. Puromycin-based purification of rat brain capillary endothelial cell cultures: effect on the expression of blood-brain barrier-specific properties. J Neurochem 2005; 93:279-89.
25. Kroesen BJ, Mesander G, ter Haar JG, The TH, de LL. Direct visualisation and quantification of cellular cytotoxicity using two colour fluorescence. J Immunol Methods 1992; 156:47-54.
26. Feng HM, Walker DH. Interferon-gamma and tumor necrosis factor-alpha exert their antirickettsial effect via induction of synthesis of nitric oxide. Am J Pathol 1993; 143:1016-23.
27. Bajenoff M, Breart B, Huang AY, et al. Natural killer cell behavior in lymph nodes revealed by static and real-time imaging. J Exp Med 2006; 203:619-31.
28. Ferlazzo G. Natural killer and dendritic cell liaison: recent insights and open questions. Immunol Lett 2005; 101:12-7.
29. H1 priming. Nat Immunol 2004; 5:1260-5.
30. Parker RR. Symptomatology and certain other aspects of Rocky Mountain spotted fever. In: Moulton FR, ed. Rickettsial diseases of man. Washington, DC: Thomas, Adams, & Davis, 1945:139-46.
31. Conor A, Bruch A. Une fievre eruptive observe. Bull Soc Pathol Exot 1910; 3:492-6.
32. Walzer T, Dalod M, Robbins SH, Zitvogel L, Vivier E. Natural-killer cells and dendritic cells: "l'union fait la force." Blood 2005; 106:2252-8.