The efficient synthesis of (3R,4R,5R)-3-amino-4,5-dimethyl-octanoic acid, a chiral β-amino acid with potent affinity for the α2δ protein

Tetrahedron Letters

Volumn 50, Issue 11, 2009, Pages 1167-1170

  Zhang, Ji ^a   Blazecka, Peter G ^a   Pflum, Derek A ^a   Bozelak, Joseph ^a   Vrieze, Derek ^a   Colbry, Norman L ^a   Hoge, Garrett ^a   Boyles, David C ^a   Samas, Brian ^a   Curran, Timothy T ^a   Osuma, Augustine T ^a   Johnson, Paul ^a   Kesten, Suzanne ^a   Schwarz, Jacob B ^a   Goodman, Annise ^a   Plummer, Mark ^a   Akin, Anne ^a   Huang, Yun ^a   Lovdahl, Michael ^a   Thorpe, Andrew J ^a  

^a PFIZER INC   (United States)

Author keywords

Ketoester; Asymmetric conjugate addition; Chiral amino acid; Organocuprate; Oxazolidinone; Stereoselective catalytic hydrogenation

Indexed keywords

3 AMINO 4,5 DIMETHYL OCTANOIC ACID; ALPHA2 DELTA PROTEIN; AMIDE; BETA AMINO ACID; METHYL GROUP; PROTEIN; UNCLASSIFIED DRUG;

ARTICLE; CHIRALITY; DRUG PROTEIN BINDING; DRUG SYNTHESIS; DRUG TARGETING; EPIMERIZATION; HYDROGENATION; PROTON TRANSPORT; STEREOCHEMISTRY;

EID: 58849130973     PISSN: 00404039     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.tetlet.2008.12.111     Document Type: Article

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