Synthesis, in vitro antitrypanosomal and antibacterial activity of phenoxy, phenylthio or benzyloxy substituted quinolones

Bioorganic and Medicinal Chemistry Letters

Volumn 19, Issue 3, 2009, Pages 986-989

  Ma, Xiang ^a,b   Zhou, Weicheng ^a   Brun, Reto ^c  

^a SHANGHAI INSTITUTE OF PHARMACEUTICAL INDUSTRY   (China)

^b NATIONAL UNIVERSITY OF SINGAPORE   (Singapore)

^c SWISS TROPICAL AND PUBLIC HEALTH INSTITUTE   (Switzerland)

Author keywords

Antibacterial activity; Antitrypanosomal; Chagas' disease; Quinolones; Trypanosoma cruzi

Indexed keywords

7,8 DIBENZYLOXYFLUOROQUINOLONE; ANTIINFECTIVE AGENT; ANTITRYPANOSOMAL AGENT; LOMEFLOXACIN; QUINOLONE DERIVATIVE; UNCLASSIFIED DRUG;

ANTIBACTERIAL ACTIVITY; ANTIMICROBIAL ACTIVITY; ANTITRYPANOSOMAL ACTIVITY; ARTICLE; CHAGAS DISEASE; CONFORMATIONAL TRANSITION; DRUG EFFICACY; DRUG POTENCY; DRUG SCREENING; DRUG SELECTIVITY; DRUG STRUCTURE; DRUG SYNTHESIS; IC 50; IN VITRO STUDY; MINIMUM INHIBITORY CONCENTRATION; NONHUMAN; TRYPANOSOMA CRUZI;

ANIMALS; ANTI-BACTERIAL AGENTS; ANTINEOPLASTIC AGENTS; CHAGAS DISEASE; CHEMISTRY, PHARMACEUTICAL; DRUG DESIGN; DRUG EVALUATION, PRECLINICAL; HUMANS; INHIBITORY CONCENTRATION 50; MAGNETIC RESONANCE SPECTROSCOPY; MODELS, CHEMICAL; NITROIMIDAZOLES; QUINOLONES; TRYPANOCIDAL AGENTS; TRYPANOSOMA CRUZI;

TRYPANOSOMA CRUZI;

EID: 58849125683     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2008.11.078     Document Type: Article

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23. 5: C, 69.79; H, 4.96; N, 3.13. Found: C, 69.55; H, 4.97; N, 3.14.
24. 5: C, 70.11; H, 4.53; N, 3.14. Found: C, 69.86; H, 4.43; N, 3.03.
25. 50 values were calculated. The experiment was carried out in triplicate.
26. MICs were determined as described by the NCCLS (see National Committee for Clinical Laboratory Standards. Performance Standards for Antimicrobial Susceptibility Testing: 11th Informational Supplement, National Committee for Clinical Laboratory Standards: Wayne, PA, 2001; Vol. 21, M100-S11.
27. Statistical analysis was performed with the Spearman test (two tails) using SPSS version 16.0.