Endocrinology of female puberty

Current Opinion in Endocrinology, Diabetes and Obesity

Volumn 16, Issue 1, 2009, Pages 1-4

  DiVall, Sara A ^a,b   Radovick, Sally ^a  

^a JOHNS HOPKINS UNIVERSITY   (United States)

^b JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

G protein coupled receptor 54; Gonadotropin releasing hormone; Kisspeptin; Obesity; Pubertal onset

Indexed keywords

G PROTEIN COUPLED RECEPTOR 54; GONADORELIN; KISSPEPTIN; TESTOSTERONE;

AFRICAN AMERICAN; BRAIN NERVE CELL; HUMAN; HYPERANDROGENISM; HYPERINSULINEMIA; HYPOTHALAMUS; LOW BIRTH WEIGHT; NONHUMAN; OBESITY; PUBERTY; REVIEW;

AFRICAN CONTINENTAL ANCESTRY GROUP; AGE FACTORS; BREAST; CHILD; EUROPEAN CONTINENTAL ANCESTRY GROUP; FEMALE; HAIR; HUMANS; OBESITY; PUBERTY; UNITED STATES;

EID: 58849120998     PISSN: 1752296X     EISSN: None     Source Type: Journal    
DOI: 10.1097/MED.0b013e3283207937     Document Type: Review

References (40)

1. Tanner JM. The assessment of growth and development in children. Arch Dis Child 1952; 27:10-33.
2. Tanner JM, Davies PS. Clinical longitudinal standards for height and height velocity for North American children. J Pediatr 1985; 107:317-329.
3. Herman-Giddens M, Slora E, Wasserman R, et al. Secondary sexual characteristics and menses in young girls seen in office practice: a study from the pediatric research in office settings network. Pediatrics 1997; 99:505-512.
4. Kaplowitz P, Oberfield S, the Drug and Therapeutics and Executive Committees of the Lawson Wilkins Pediatric Endocrine Society. Reexamination of the age limit for defining when puberty is precocious in girls in the United States: implications for evaluation and treatment. Pediatrics 1999; 104:936-941.
5. Finlay F, Jones R, Kaplowitz P, Oberfield S. Precocious puberty. Pediatrics 2000; 106:162b-163b.
6. Rosenfield R, Bachrach L, Chernausek S, et al. Current age of onset of puberty. Pediatrics 2000; 106:622-623.
7. Sun S, Schubert C, Chumlea W, et al. National estimates of the timing of sexual maturation and racial differences among US children. Pediatrics 2002; 110:911-919.
8. Wu T, Mendola P, Buck G. Ethnic differences in the presence of secondary sex characteristics and menarche among US girls: the Third National Health and Nutrition Examination Survey, 1988-1994. Pediatrics 2002; 110:752-757.
9. Euling SY, Herman-Giddens ME, Lee PA, et al. Examination of US puberty-timing data from 1940 to 1994 for secular trends: panel findings. Pediatrics 2008; 121 (Suppl 3):S172-S191. This expert panel statement reviews the studies concerning the trends in pubertal timing, summarizes the panel members' consensus conclusions based on the data, and presents proposals for future research directions.
10. Golub MS, Collman GW, Foster PMD, et al. Public health implications of altered puberty timing. Pediatrics 2008; 121 (Suppl 3):S218-S230.
11. Lee JM, Appugliese D, Kaciroti N, et al. Weight status in young girls and the onset of puberty. Pediatrics 2007; 119:e624-e630. This study found an association between excessive weight gain in early childhood with early onset of puberty in girls.
12. Sloboda DM, Hart R, Doherty DA, et al. Age at menarche: influences of prenatal and postnatal growth. J Clin Endocrinol Metab 2007; 92:46-50.
13. Apter D, Butzow T, Laughlin G, Yen S. Gonadotropin-releasing hormone pulse generator activity during pubertal transition in girls: pulsatile and diurnal patterns of circulating gonadotropins. J Clin Endocrinol Metab 1993; 76:940-949.
14. Mitamura R, Yano K, Suzuki N, et al. Diurnal rhythms of luteinizing hormone, follicle-stimulating hormone, testosterone, and estradiol secretion before the onset of female puberty in short children. J Clin Endocrinol Metab 2000; 85:1074-1080.
15. Legro R, Lin H, Demers L, Lloyd T. Rapid maturation of the reproductive axis during perimenarche independent of body composition. J Clin Endocrinol Metab 2000; 85:1021-1025.
16. Resende EAMR, Lara BHJ, Reis JD, et al. Assessment of basal and gonadotropin-releasing hormone-stimulated gonadotropins by immunochemiluminometric and immunofluorometric assays in normal children. J Clin Endocrinol Metab 2007; 92:1424-1429.
17. McCartney CR, Prendergast KA, Chhabra S, et al. The association of obesity and hyperandrogenemia during the pubertal transition in girls: obesity as a potential factor in the genesis of postpubertal hyperandrogenism. J Clin Endocrinol Metab 2006; 91:1714-1722.
18. McCartney CR, Blank SK, Prendergast KA, et al. Obesity and sex steroid changes across puberty: evidence for marked hyperandrogenemia in pre and early pubertal obese girls. J Clin Endocrinol Metab 2007; 92:430-436. This study compares the serum testosterone and progesterone during the different stages of puberty between obese and normal-weight girls.
19. Ibanez L, Jimenez R, de Zegher F. Early puberty-menarche after precocious pubarche: relation to prenatal growth. Pediatrics 2006; 117:117-121.
20. Ibanez L, Ong K, Valls C, et al. Metformin treatment to prevent early puberty in girls with precocious pubarche. J Clin Endocrinol Metab 2006; 91:2888-2891.
21. Ibanez L, Valls C, Ong K, et al. Metformin therapy during puberty delays menarche, prolongs pubertal growth, and augments adult height: a randomized study in low-birth-weight girls with early-normal onset of puberty. J Clin Endocrinol Metab 2006; 91:2068-2073.
22. Kaplowitz PB. Link between body fat and the timing of puberty. Pediatrics 2008; 121 (Suppl 3):S208-S217.
23. Strobel A, Issad T, Camoin L, et al. A leptin missense mutation associated with hypogonadism and morbid obesity. Nat Genet 1998; 18:213-215.
24. Farooqi IS, Wangensteen T, Collins S, et al. Clinical and molecular genetic spectrum of congenital deficiency of the leptin receptor. N Engl J Med 2007; 356:237-247. This study describes the phenotype of individuals found to have mutations in the leptin receptor gene.
25. Bruning JC, Gautam D, Burks DJ, et al. Role of brain insulin receptor in control of body weight and reproduction. Science 2000; 289:2122-2125.
26. Garcia MC, Lopez M, Alvarez CV, et al. Role of ghrelin in reproduction. Reproduction 2007; 133:531-540.
27. Gottsch ML, Clifton DK, Steiner RA. Galanin-like peptide as a link in the integration of metabolism and reproduction. Trends Endocrinol Metab 2004; 15:215-221.
28. Terasawa E, Fernandez D. Neurobiological mechanisms of the onset of puberty in primates. Endocr Rev 2001; 22:111-151.
29. Wildt L, Marshall G, Knobil E. Experimental induction of puberty in the infantile female rhesus monkey. Science 1980; 207:1373-1375.
30. deRoux N, Genin E, Carel J, et al. Hypogonadotropic hypogonadism due to loss of function of the KiSS1-derived peptide receptor GPR54. Proc Natl Acad Sci U S A 2003; 100:10972-10976.
31. Seminara S, Messager S, Chatzidaki E, et al. The GPR54 gene as a regulator of puberty. N Engl J Med 2003; 349:1614-1627.
32. Irwig MS, Fraley GS, Smith JT, et al. Kisspeptin activation of gonadotropin releasing hormone neurons and regulation of KiSS-1 mRNA in the male rat. Neuroendocrinology 2004; 80:264-272.
33. Messager S, Chatzidaki E, Ma D, et al. Kisspeptin directly stimulates gonadotropin-releasing hormone release via G protein-coupled receptor 54. Proc Natl Acad Sci U S A 2005; 102:1761-1766.
34. Shahab M, Mastronardi C, Seminara S, et al. Increased hypothalamic GPR54 signaling: a potential mechanism for initiation of puberty in primates. Proc Natl Acad Sci U S A 2005; 102:2129-2134.
35. Navarro VM, Fernandez-Fernandez R, Castellano JM, et al. Advanced vaginal opening and precocious activation of the reproductive axis by KiSS-1 peptide, the endogenous ligand of GPR54. J Physiol 2004; 561:379-386.
36. d'Anglemont de Tassigny X, Fagg LA, Dixon JPC, et al. Hypogonadotropic hypogonadism in mice lacking a functional Kiss1 gene. Proc Natl Acad Sci U S A 2007; 104:10714-10719. This study describes the generation and reproductive phenotype of mice lacking the kisspeptin gene.
37. Lapatto R, Pallais JC, Zhang D, et al. Kiss1/mice exhibit more variable hypogonadism than Gpr54/mice. Endocrinology 2007; 148:4927-4936. This study compares the reproductive phenotype of mice lacking the kisspeptin gene with mice lacking the GPR54 gene.
38. Dungan HM, Gottsch ML, Zeng H, et al. The role of kisspeptin GPR54 signaling in the tonic regulation and surge release of gonadotropin-releasing hormone/luteinizing hormone. J Neurosci 2007; 27:12088-12095.
39. Smith JT, Rao A, Pereira A, et al. Kisspeptin is present in ovine hypophysial portal blood but does not increase during the preovulatory luteinizing hormone surge: evidence that gonadotropes are not direct targets of kisspeptin in vivo. Endocrinology 2008; 149:1951-1959.
40. Teles MG, Bianco SDC, Brito VN, et al. A GPR54-activating mutation in a patient with central precocious puberty. N Engl J Med 2008; 358:709-715. This case report describes a child with precocious puberty and a mutation in the GPR54 gene. The mutation was found to disrupt GPR54 receptor-mediated intracellular signaling.