Epigenetics - Gene silencing

Journal of Association of Physicians of India

Volumn 57, Issue JAN., 2009, Pages 60-66

  Lele, R D ^a,b,c,d,e  

^a JASLOK HOSPITAL AND RESEARCH CENTRE   (India)

^b LILAVATI HOSPITAL AND RESEARCH CENTRE   (India)

^c GRANT MEDICAL COLLEGE   (India)

^d All India Institute of Diabetes   (India)

^e National Academy of Medical Sciences   (India)

Author keywords

[No Author keywords available]

Indexed keywords

ANTISENSE OLIGONUCLEOTIDE;

ALTERNATIVE RNA SPLICING; DEGENERATIVE DISEASE; GENE EXPRESSION; GENE SILENCING; GENETIC EPIGENESIS; HUMAN; RESPIRATORY TRACT DISEASE; REVIEW; RNA INTERFERENCE; RNA PROCESSING; RNA SPLICING; NEURODEGENERATIVE DISEASES; RESPIRATORY TRACT DISEASES;

ALTERNATIVE SPLICING; EPIGENESIS, GENETIC; GENE EXPRESSION; GENE SILENCING; HUMANS; NEURODEGENERATIVE DISEASES; OLIGONUCLEOTIDES, ANTISENSE; RESPIRATORY TRACT DISEASES; RNA INTERFERENCE; RNA PROCESSING, POST-TRANSCRIPTIONAL; RNA SPLICING;

EID: 58849102588     PISSN: 00045772     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Review

References (26)

1. Bertil Daneholt. The Nobel Prize in physiology and Medicine 2006. The Nobel Assembly at Karolinska Institute.
2. Fire A, XuS, Montgomery MK, Kostas SA, Driver SE and Mello-CC : Potent and specific genetic interference by double stranded RNA in aenorhabditis elegans. Nature 1998;391:806-11.
3. Hannon GL. RNA interference. Nature 2002;418:244-51.
4. Mello C , Conte D. Revealing the world of RNA interference Nature 2004;431:338-342.
5. Meuster G, Tuschl T. Mechanisms of gene silencing by double stranded RNA. Nature 2004;431:343-9.
6. Hammond SM. Dicing and Slicing. The core machinery of the RNA interference pathway. FEBS Letters 2005;579:5822-9.
7. Plastre K. RHA RNA silencing : the Genome's immune system. Science 2002;296:1263-65.
8. Dorsett Y, Tuschl T. SiRNA- applications in functional genomics and potentials in therapeutic. Nature Reviews 2004.
9. Hannon GJ, Rose JJ. Unlocking the potential of the human genome with RNA interference. Nature 2004;431:371-8.
10. Soutschek J, et al. Therapeutic silencing of an endogenomic gene by systemic administration of modified SiRNA. Nature 2004, 432, 173-178.
11. Morrsey DV, et al. Potent and persistent invivo antiHBV activity of chemically modified siRNA. Nature 2005;23:1002-7.
12. Simmerman TS, et al. RNAi mediated gene silencing in nonhuman primates. Nature 2006;441:111-4.
13. Deewanjee Mrinal K, et al. Development of sensitive radioiodinated antisense oligonucleotide probes by conjugation techniques. Bioconjug Chem 1992;2:195-200.
14. Hnatowich DJ. Antisense imaging. Where are we now? Cancer Biother Radiopharm 2000;15:447-57.
15. Askari FK, Mc Donnell WM. Antisense oligonuclotide therapy. NEJM 1996;334:316-8.
16. Wickstrom E. Clinical trials of genetic therapy with antisense DNA and DNA vectors. Ibid- ASON for cMYC mRNA in Burkitt's lymphoma 1998 J Natl Cancer Instit 1998 Aug.
17. Drugan H, et al. Hybridization and cell uptake studies with radiolabelled antisense oligonucleotides. Nucl Med Common 2001;22:1171-9.
18. Cunningham CC . New modalities in oncology: antisense oligonucleotides. BUMC Proceedings 2002;15:125-8.
19. J Maxon, RN, C Weaver, MD, Antisense Therapy - An overview, Cur Topics in Oncology, January 2005.
20. Amith RA, et al. Antisense oligonucleotide therapy for neurodegenerative disease. J Clin Invest 2006;116:2290-6.
21. Tanaka M, Nyce JW. Respirable antisense oligonucleotides a new drug class for respiratory disease. Resp Res 2001;2:5-9.
22. Sanazi Pand Kole R. T herapeutic potential of antisense oligonucleotides as modulators of alternative splicing. J Clin Invest 2003;112:481-6.
23. Morcos O. Achieving targeted and quantifiable alteration of mRNA slicing with Morpholino oligos. Bioch Biophy Res Common 2007;358:521-7.
24. Johnson JM, et al. Genome-wide survey of human alternative pre-mRNA splicing with exon-junction micro-arrays. Science 2003;302:2141-4.
25. Garcia-Blanco MA, et al. Alternative splicing in disease and therapy. Nat Biotechn 2004;22:535-46.
26. IIS gttp://www.isispharm.com/antisense-tech-phtml.