Gastrin, Helicobacter pylori, and Colorectal Adenomas

Clinical Gastroenterology and Hepatology

Volumn 7, Issue 2, 2009, Pages 163-167

  Robertson, Douglas J ^a,b   Sandler, Robert S ^c   Ahnen, Dennis J ^d,e   Greenberg, E Robert ^f,h   Mott, Leila A ^f,g   Cole, Bernard F ^f,g,i   Baron, John A ^f,g  

^a VA MEDICAL CENTER   (United States)

^b DARTMOUTH MEDICAL SCHOOL   (United States)

^c UNIVERSITY OF NORTH CAROLINA SCHOOL OF MEDICINE   (United States)

^d VETERANS AFFAIRS MEDICAL CENTER   (United States)

^e UNIVERSITY OF COLORADO SCHOOL OF MEDICINE   (United States)

^f Departments of Community and Family Medicine   (United States)

^g DARTMOUTH HITCHCOCK MEDICAL CENTER   (United States)

^h Fred Hutchinson Cancer Research Center   (United States)

ⁱ University of Vermont   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALPHA TOCOPHEROL; ASCORBIC ACID; BETA CAROTENE; CALCIUM CARBONATE; GASTRIN;

ADULT; ADVANCED CANCER; ARTICLE; BACTERIAL COUNT; CANCER CHEMOTHERAPY; CANCER GROWTH; CANCER PREVENTION; CANCER RISK; COLONOSCOPY; COLORECTAL ADENOMA; CONFIDENCE INTERVAL; DIET RESTRICTION; FEMALE; FOLLOW UP; GASTRIN BLOOD LEVEL; HELICOBACTER INFECTION; HUMAN; HUMAN TISSUE; HYPERGASTRINEMIA; LINEAR REGRESSION ANALYSIS; MAJOR CLINICAL STUDY; MALE; SEROLOGY;

ADENOMA; ANTIBODIES, BACTERIAL; COLORECTAL NEOPLASMS; FEMALE; GASTRINS; HELICOBACTER INFECTIONS; HUMANS; MALE; MIDDLE AGED; ODDS RATIO; RISK ASSESSMENT;

EID: 58849095332     PISSN: 15423565     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.cgh.2008.09.006     Document Type: Article

References (40)

1. Levi S., Beardshall K., Swift I., et al. Antral Helicobacter pylori, hypergastrinaemia, and duodenal ulcers: effect of eradicating the organism. BMJ 299 (1989) 1504-1505
2. Graham D.Y., Opekun A., Lew G.M., et al. Ablation of exaggerated meal-stimulated gastrin release in duodenal ulcer patients after clearance of Helicobacter (Campylobacter) pylori infection. Am J Gastroenterol 85 (1990) 394-398
3. Prewett E.J., Smith J.T., Nwokolo C.U., et al. Eradication of Helicobacter pylori abolishes 24-hour hypergastrinaemia: a prospective study in healthy subjects. Aliment Pharmacol Ther 5 (1991) 283-290
4. Ciccotosto G.D., McLeish A., Hardy K.J., et al. Expression, processing, and secretion of gastrin in patients with colorectal carcinoma. Gastroenterology 109 (1995) 1142-1153
5. Watson S.A., Durrant L.G., Crosbie J.D., et al. The in vitro growth response of primary human colorectal and gastric cancer cells to gastrin. Int J Cancer 43 (1989) 692-696
6. Smith J.P., and Solomon T.E. Effects of gastrin, proglumide, and somatostatin on growth of human colon cancer. Gastroenterology 95 (1988) 1541-1548
7. Hoosein N.M., Kiener P.A., Curry R.C., et al. Antiproliferative effects of gastrin receptor antagonists and antibodies to gastrin on human colon carcinoma cell lines. Cancer Res 48 (1988) 7179-7183
8. Watson S.A., Michaeli D., Grimes S., et al. Anti-gastrin antibodies raised by gastrimmune inhibit growth of the human colorectal tumour AP5. Int J Cancer 61 (1995) 233-240
9. Beauchamp R.D., Townsend Jr. C.M., Singh P., et al. Proglumide, a gastrin receptor antagonist, inhibits growth of colon cancer and enhances survival in mice. Ann Surg 202 (1985) 303-309
10. Sobhani I., Lehy T., Laurent-Puig P., et al. Chronic endogenous hypergastrinemia in humans: evidence for a mitogenic effect on the colonic mucosa. Gastroenterology 105 (1993) 22-30
11. Renga M., Brandi G., Paganelli G.M., et al. Rectal cell proliferation and colon cancer risk in patients with hypergastrinaemia. Gut 41 (1997) 330-332
12. Smith J.P., Wood J.G., and Solomon T.E. Elevated gastrin levels in patients with colon cancer or adenomatous polyps. Dig Dis Sci 34 (1989) 171-174
13. Wong K., Beardshall K., Waters C.M., et al. Postprandial hypergastrinaemia in patients with colorectal cancer. Gut 32 (1991) 1352-1354
14. Charnley R.M., Thomas W.M., Stanley J., et al. Serum gastrin concentrations in colorectal cancer patients. Ann R Coll Surg Engl 74 (1992) 138-141
15. Seitz J.F., Giovannini M., Gouvernet J., et al. Elevated serum gastrin levels in patients with colorectal neoplasia. J Clin Gastroenterol 13 (1991) 541-545
16. Suzuki H., Matsumoto K., and Terashima H. Serum levels of gastrin in patients with colorectal neoplasia. Dis Colon Rectum 31 (1988) 716-717
17. Yapp R., Modlin I.M., Kumar R.R., et al. Gastrin and colorectal cancer. Evidence against an association. Dig Dis Sci 37 (1992) 481-484
18. Penman I.D., el-Omar E., Ardill J.E., et al. Plasma gastrin concentrations are normal in patients with colorectal neoplasia and unaltered following tumor resection. Gastroenterology 106 (1994) 1263-1270
19. Kikendall J.W., Glass A.R., Sobin L.H., et al. Serum gastrin is not higher in subjects with colonic neoplasia. Am J Gastroenterol 87 (1992) 1394-1397
20. Thorburn C.M., Friedman G.D., Dickinson C.J., et al. Gastrin and colorectal cancer: a prospective study. Gastroenterology 115 (1998) 275-280
21. Robertson D.J., Larsson H., Friis S., et al. Proton pump inhibitor use and risk of colorectal cancer: a population-based, case-control study. Gastroenterology 133 (2007) 755-760
22. Yang Y.X., Hennessy S., Propert K., et al. Chronic proton pump inhibitor therapy and the risk of colorectal cancer. Gastroenterology 133 (2007) 748-754
23. Muto T., Bussey H.J., and Morson B.C. The evolution of cancer of the colon and rectum. Cancer 36 (1975) 2251-2270
24. Baron J.A., Beach M., Mandel J.S., et al. Calcium supplements for the prevention of colorectal adenomas. Calcium Polyp Prevention Study Group. N Engl J Med 340 (1999) 101-107
25. Greenberg E.R., Baron J.A., Tosteson T.D., et al. A clinical trial of antioxidant vitamins to prevent colorectal adenoma. Polyp Prevention Study Group. N Engl J Med 331 (1994) 141-147
26. Johnson L.R. Regulation of gastrointestinal mucosal growth. Physiol Rev 68 (1988) 456-502
27. Smith A.M., and Watson S.A. Gastrin and gastrin receptor activation: an early event in the adenoma-carcinoma sequence. Gut 47 (2000) 820-824
28. Finley G.G., Koski R.A., Melhem M.F., et al. Expression of the gastrin gene in the normal human colon and colorectal adenocarcinoma. Cancer Res 53 (1993) 2919-2926
29. Koh T.J., Bulitta C.J., Fleming J.V., et al. Gastrin is a target of the beta-catenin/TCF-4 growth-signaling pathway in a model of intestinal polyposis. J Clin Invest 106 (2000) 533-539
30. Wong N.A., and Pignatelli M. Beta-catenin-a linchpin in colorectal carcinogenesis?. Am J Pathol 160 (2002) 389-401
31. Mihas A.A., Maliakkal R.J., Shueke M., et al. Serum gastrin levels in patients with colorectal cancer and adenomatous polyps: a prospective study. Res Commun Mol Pathol Pharmacol 90 (1995) 301-304
32. Georgopoulos S.D., Polymeros D., Triantafyllou K., et al. Hypergastrinemia is associated with increased risk of distal colon adenomas. Digestion 74 (2006) 42-46
33. Lamberts R., Wartenberg T., and Creutzfeldt W. Role of circulating gastrin in colorectal adenomas and carcinomas. Digestion 60 (1999) 101-109
34. Vanderstraeten E.F., De Vos M.M., Versieck J.M., et al. Serum gastrin levels and colorectal neoplasia. Dis Colon Rectum 38 (1995) 172-176
35. Konturek S.J., Konturek P.C., Hartwich A., et al. Helicobacter pylori infection and gastrin and cyclooxygenase expression in gastric and colorectal malignancies. Regul Pept 93 (2000) 13-19
36. Meucci G., Tatarella M., Vecchi M., et al. High prevalence of Helicobacter pylori infection in patients with colonic adenomas and carcinomas. J Clin Gastroenterol 25 (1997) 605-607
37. Breuer-Katschinski B., Nemes K., Marr A., et al. Helicobacter pylori and the risk of colonic adenomas. Colorectal Adenoma Study Group. Digestion 60 (1999) 210-215
38. Aydin A., Karasu Z., Zeytinoglu A., et al. Colorectal adenomatous polyps and Helicobacter pylori infection. Am J Gastroenterol 94 (1999) 1121-1122
39. Fujimori S., Kishida T., Kobayashi T., et al. Helicobacter pylori infection increases the risk of colorectal adenoma and adenocarcinoma, especially in women. J Gastroenterol 40 (2005) 887-893
40. Aly A., Shulkes A., and Baldwin G.S. Gastrins, cholecystokinins and gastrointestinal cancer. Biochim Biophys Acta 1704 (2004) 1-10