5-[18F]Fluoroalkyl pyrimidine nucleosides: probes for positron emission tomography imaging of herpes simplex virus type 1 thymidine kinase gene expression

Nuclear Medicine and Biology

Volumn 36, Issue 1, 2009, Pages 29-38

  Chacko, Ann Marie ^a   Blankemeyer, Eric ^b   Lieberman, Brian P ^b   Qu, Wenchao ^b   Kung, Hank F ^b  

^a UNIVERSITY OF PENNSYLVANIA   (United States)

^b UNIVERSITY OF PENNSYLVANIA   (United States)

Author keywords

5 18F Fluoroalkyl pyrimidine nucleosides; HSV1 tk; PET; Reporter gene imaging

Indexed keywords

2' FLUORO 2' DEOXY 5 (3 FLUOROPROPYL) 1 BETA DEXTRO ARABINOFURANOSYLURACIL F 18; 2' FLUORO 2' DEOXY 5 (4 FLUOROBUTYL) 1 BETA DEXTRO ARABINOFURANOSYLURACIL F 18; 2' FLUORO 2' DEOXY 5 (5 FLUOROPENTYL) 1 BETA DEXTRO ARABINOFURANOSYLURACIL F 18; 5 (3 FLUOROPROPYL) 2' DEOXYURIDINE F 18; 5 (4 FLUOROBUTYL) 2' DEOXYURIDINE F 18; 5 (5 FLUOROPENTYL) 2' DEOXYURIDINE F 18; FLUORINE 18; PYRIMIDINE NUCLEOSIDE; THYMIDINE KINASE; UNCLASSIFIED DRUG; DRUG DERIVATIVE; FIALURIDINE; FLUORINE; URACIL ARABINOSIDE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DRUG CLEARANCE; DRUG DISTRIBUTION; DRUG STRUCTURE; FLUORINATION; GENE EXPRESSION; HERPES SIMPLEX VIRUS 1; MOUSE; NONHUMAN; POSITRON EMISSION TOMOGRAPHY; RAT; REPORTER GENE; TUMOR XENOGRAFT; ANIMAL; BIOSYNTHESIS; BLOOD; ENZYMOLOGY; GENETICS; GLIOMA; MALE; METABOLISM; NUDE MOUSE; REPRODUCIBILITY; SENSITIVITY AND SPECIFICITY; TIME; TISSUE DISTRIBUTION; TUMOR CELL LINE; XENOGRAFT;

ANIMALS; ARABINOFURANOSYLURACIL; CELL LINE, TUMOR; FLUORINE RADIOISOTOPES; GENE EXPRESSION; GENES, REPORTER; GLIOMA; HERPESVIRUS 1, HUMAN; MALE; MICE; MICE, NUDE; POSITRON-EMISSION TOMOGRAPHY; PYRIMIDINE NUCLEOSIDES; RATS; REPRODUCIBILITY OF RESULTS; SENSITIVITY AND SPECIFICITY; THYMIDINE KINASE; TIME FACTORS; TISSUE DISTRIBUTION; TRANSPLANTATION, HETEROLOGOUS;

EID: 58749113471     PISSN: 09698051     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.nucmedbio.2008.10.009     Document Type: Article

References (29)

1. Jacobs A., Voges J., Reszka R., Lercher M., Gossmann A., Kracht L., et al. Positron-emission tomography of vector-mediated gene expression in gene therapy for gliomas. Lancet 358 (2001) 727-729
2. Jacobs A.H., Rueger M.A., Winkeler A., Li H., Vollmar S., Waerzeggers Y., et al. Imaging-guided gene therapy of experimental gliomas. Cancer Res 67 (2007) 1706-1715
3. Lu Y., Dang H., Middleton B., Campbell-Thompson M., Atkinson M.A., Gambhir S.S., et al. Long-term monitoring of transplanted islets using positron emission tomography. Mol Ther 14 (2006) 851-856
4. Brader P., Riedl C.C., Woo Y., Ponomarev V., Zanzonico P., Wen B., et al. Imaging of hypoxia-driven gene expression in an orthotopic liver tumor model. Mol Cancer Ther 6 (2007) 2900-2908
5. Doubrovin M., Ponomarev V., Beresten T., Balatoni J., Bornmann W., Finn R., et al. Imaging transcriptional regulation of p53-dependent genes with positron emission tomography in vivo. Proc Natl Acad Sci USA 98 (2001) 9300-9305
6. Tjuvajev J.G., Stockhammer G., Desai R., Uehara H., Watanabe K., Gansbacher B., et al. Imaging the expression of transfected genes in vivo. Cancer Res 55 (1995) 6126-6132
7. Tjuvajev J.G., Finn R., Watanabe K., Joshi R., Oku T., Kennedy J., et al. Noninvasive imaging of herpes virus thymidine kinase gene transfer and expression: a potential method for monitoring clinical gene therapy. Cancer Res 56 (1996) 4087-4095
8. 18F]FHBG): a new potential imaging agent for viral infection and gene therapy using PET. Nucl Med Biol 25 (1998) 175-180
9. 18F-FHBG: a PET reporter probe for imaging herpes simplex virus type 1 thymidine kinase (HSV1-tk) or mutant HSV1-sr39tk's expression. J Nucl Med 47 (2006) 706-715
10. 124/125I]FIAU for imaging herpes simplex virus type 1 thymidine kinase gene expression. Eur J Nucl Med 28 (2001) 721-729
11. 18F]-FHPG): a potential imaging agent of viral infection and gene therapy using PET. Nucl Med Biol 23 (1996) 787-792
12. Gambhir S.S., Bauer E., Black M.E., Liang Q., Kokoris M.S., Barrio J.R., et al. A mutant herpes simplex virus type 1 thymidine kinase reporter gene shows improved sensitivity for imaging reporter gene expression with positron emission tomography. Proc Natl Acad Sci USA 97 (2000) 2785-2790
13. 18F-FEAU as a radiotracer for herpes simplex virus thymidine kinase gene expression: in-vitro comparison with other PET tracers. Nucl Med Commun 27 (2006) 25-30
14. Serganova I., Doubrovin M., Vider J., Ponomarev V., Soghomonyan S., Beresten T., et al. Molecular imaging of temporal dynamics and spatial heterogeneity of hypoxia-inducible factor-1 signal transduction activity in tumors in living mice. Cancer Res 64 (2004) 6101-6108
15. 18F]FEAU) as markers for suicide gene expression. Eur J Nucl Med Mol Imaging 34 (2007) 822-829
16. 18F]FFEAU, and other imaging probes. J Nucl Med 49 (2008) 637-648
17. 18F]FEAU: a novel PET imaging agent for HSV1-tk/sr39tk reporter gene expression. Mol Imaging Biol 10 (2008) 82-91
18. 18F]-FMAU). J Label Compd Radiopharm 45 (2002) 583-590
19. 18F]fluoro-1-beta-d-arabinofuranosyluracil and its 5-substituted nucleosides. J Label Compd Radiopharm 46 (2003) 285-289
20. 18F]-labeled nucleosides. Synth Commun 32 (2002) 1757-1764
21. 18F]labelled FAU, FMAU, FBAU, FIAU. Nucl Med Biol 30 (2003) 215-224
22. 18F]fluoroethyl-1-beta-d-arabinofuranosyl uracil. Nucl Med Biol 32 (2005) 811-819
23. 18F]fluoroalkylated nucleosides for PET imaging of HSV1-tk gene expression. J Nucl Med 49 (2008) 12P
24. 18F]fluoroalkyl pyrimidine nucleosides for molecular imaging of herpes simplex virus type 1 thymidine kinase reporter gene expression. J Med Chem 51 (2008) 5690-5701
25. Chacko A.M., Qu W., and Kung H.F. Synthesis of 5-fluoroalkylated pyrimidine nucleosides via Negishi cross-coupling. J Org Chem 73 (2008) 4874-4881
26. 123I]FIAU. Acad Radiol 12 (2005) 798-805
27. Surti S., Karp J.S., Perkins A.E., Cardi C.A., Daube-Witherspoon M.E., Kuhn A., et al. Imaging performance of A-PET: a small animal PET camera. IEEE Trans Med Imaging 24 (2005) 844-852
28. Alauddin M.M., Shahinian A., and Conti P.S. Evaluation of 2′-deoxy-2′-fluoro-5-substituted-1-beta-d-arabinofuranosyluracils as markers for suicide gene expression in cancer cells. J Nucl Med 46 (2005) 35P
29. Issa W., Tochon-Danguy H.J., Lambert J., Sachinidis J.I., Ackermann U., Liu Z., et al. Synthesis and evaluation of a thymidine analog for positron emission tomography study of tumor DNA proliferation in vivo. Nucl Med Biol 31 (2004) 839-849