Increased prevalence of hyperhomocysteinemia in cervical artery dissection causing stroke: A case-control study

Cerebrovascular Diseases

Volumn 27, Issue 3, 2009, Pages 241-246

  Benninger, David H ^a   Herrmann, François R ^b   Georgiadis, Dimitri ^a   Kretschmer, Robert ^c   Sarikaya, Hakan ^a   Schiller, Andreas ^a   Baumgartner, Ralf W ^a  

^a UNIVERSITY HOSPITAL ZURICH   (Switzerland)

^b GENEVA UNIVERSITY HOSPITALS   (Switzerland)

^c UNIVERSITY OF BERN   (Switzerland)

Author keywords

Cerebrovascular disease; Cervical artery dissection; Homocysteine; Stroke

Indexed keywords

HOMOCYSTEINE;

ADULT; AGED; ARTERY DISSECTION; ARTICLE; ATHEROGENESIS; CEREBROVASCULAR ACCIDENT; CERVICAL ARTERY DISSECTION; CONTROLLED STUDY; DISEASE SEVERITY; FEMALE; HUMAN; HYPERHOMOCYSTEINEMIA; MAJOR CLINICAL STUDY; MALE; PREVALENCE; PRIORITY JOURNAL; STROKE; SYMPTOMATOLOGY; THROMBOSIS;

ADULT; AGED; AGED, 80 AND OVER; ATHEROSCLEROSIS; CASE-CONTROL STUDIES; CERVICAL VERTEBRAE; FEMALE; HOMOCYSTEINE; HUMANS; HYPERHOMOCYSTEINEMIA; LOGISTIC MODELS; MALE; MIDDLE AGED; ODDS RATIO; PREVALENCE; REGISTRIES; RETROSPECTIVE STUDIES; RISK ASSESSMENT; RISK FACTORS; SEVERITY OF ILLNESS INDEX; STROKE; THROMBOSIS; VERTEBRAL ARTERY DISSECTION; YOUNG ADULT;

EID: 58749107387     PISSN: 10159770     EISSN: None     Source Type: Journal    
DOI: 10.1159/000196822     Document Type: Article

References (33)

1. Ducrocq X, Lacour JC, Debouverie M, Bracard S, Girard F, Weber M: Cerebral ischemic accidents in young subjects: a prospective study of 296 patients aged 16 to 45 years (in French). Rev Neurol (Paris) 1999;155:575-582.
2. Nedeltchev K, der Maur TA, Georgiadis D, Arnold M, Caso V, Mattle HP, Schroth G, Remonda L, Sturzenegger M, Fischer U, Baumgartner RW: Ischaemic stroke in young adults: predictors of outcome and recurrence. J Neurol Neurosurg Psychiatry 2005;76:191-195.
3. Gallai V, Caso V, Paciaroni M, Cardaioli G, Arning E, Bottiglieri T, Parnetti L: Mild hyperhomocyst(e)inemia: a possible risk factor for cervical artery dissection. Stroke 2001;32:714-718.
4. Konrad C, Muller GA, Langer C, Kuhlenbaumer G, Berger K, Nabavi DG, Dziewas R, Stogbauer F, Ringelstein EB, Junker R: Plasma homocysteine, MTHFR C677T, CBS 844ins68bp, and MTHFD1 G1958A polymorphisms in spontaneous cervical artery dissections. J Neurol 2004;251:1242-1248.
5. Pezzini A, Del Zotto E, Archetti S, Negrini R, Bani P, Albertini A, Grassi M, Assanelli D, Gasparotti R, Vignolo LA, Magoni M, Padovani A: Plasma homocysteine concentration, C677T MTHFR genotype, and 844ins68bp CBS genotype in young adults with spontaneous cervical artery dissection and atherothrombotic stroke. Stroke 2002;33:664-669.
6. Kloss M, Wiest T, Hyrenbach S, Werner I, Arnold ML, Lichy C, Grond-Ginsbach C: MTHFR 677TT genotype increases the risk for cervical artery dissections. J Neurol Neurosurg Psychiatry 2006;77:951-952.
7. Kelly PJ, Rosand J, Kistler JP, Shih VE, Silveira S, Plomaritoglou A, Furie KL: Homocysteine, MTHFR 677C→T polymorphism, and risk of ischemic stroke - Results of a meta-analysis. Neurology 2002;59:529-536.
8. Hackam DG, Anand SS: Emerging risk factors for atherosclerotic vascular disease - a critical review of the evidence. JAMA 2003;290:932-940.
9. Fassbender K, Mielke O, Bertsch T, Nafe B, Froschen S, Hennerici M: Homocysteine in cerebral macroangiography and microangiopathy. Lancet 1999;353:1586-1587.
10. Hassan A, Hunt BJ, O'Sullivan M, Bell R, D'Souza R, Jeffery S, Bamford JM, Markus HS: Homocysteine is a risk factor for cerebral small vessel disease, acting via endothelial dysfunction. Brain 2004;127:212-219.
11. Gauthier G, Rohr J, Wildi E, Megret M: Spontaneous dissecting aneurysm of the internal carotid artery. General review of 205 published cases with 10 personal cases (in French). Schweiz Arch Neurol Psychiatr 1985;136:53-74.
12. Benninger DH, Georgiadis D, Kremer C, Studer A, Nedeltchev K, Baumgartner RW: Mechanism of ischemic infarct in spontaneous carotid dissection. Stroke 2004;35:482-485.
13. Baumgartner RW, Sidler C, Mosso M, Georgiadis D: Ischemic lacunar stroke in patients with and without potential mechanism other than small-artery disease. Stroke 2003;34:653-658.
14. Adams HP, Bendixen BH, Kappelle LJ, Biller J, Love BB, Gordon DL, Marsh EE, Kase CS, Wolf PA, Babikian VL, Licatagehr EE, Allen N, Brass LM, Fayad PB, Pavalkis FJ, Weinberger JM, Tuhrim S, Rudolph SH, Horowitz DR, Bitton A, Mohr JP, Sacco RL, Clavijo M, Rosenbaum DM, Sparr SA, Katz P, Klonowski E, Culebras A, Carey G, Martir NI, Ficarra C, Hogan EL, Carter T, Gurecki P, Muntz BK, Ramirezlassepas M, Tulloch JW, Quinones MR, Mendez M, Zhang SM, Ala T, Johnston KC, Anderson DC, Tarrel RM, Nance MA, Budlie SR, Dierich M, Helgason CM, Hier DB, Shapiro RA, Brint S, Hoff J, Karanjia PN, Madden KP, Ruggles KH, Mickel SF, Gottschalk PG, Hansotia PI, Sorenson RW, Jacobson DM, Hiner BC, Mancl K, Gorelick PB, Riskin B, Mirza D, Kelly M, Bijari A, Kofman J, Dollear WC, Gomez CR, Malkoff MD, Riaz G, Schmidt JG, Malik MM, Banet G, Byer JA, Gamboa E, Stacy M, Bonnett A, Feldmann E, Wilterdink JL, Ricks L, Bruno A, Lakind E, Jeffrey DR, Mladinich EK, King M, Chapin JE, Carter S, Fisher M, Ameriso S, Macko RF, Martin A, Rothrock JF, Lyden PD, Brody ML, Kelly NM, Coull BM, Briley DP, Clark WM, Austin T, Degarmo PL, Adams HP, Dyken E, Yasar E, Bendixen B, Wojcieszek J, Kappelle J, Mitchell V, Frank J, Saver JL, Chadwick L, Mayman CI, Warach S, Tijerina ML, Miller A, Keilson M, Drexler E, Morgante L, Mandelbaum MA, Hassan R, Abbas DH, Olmstead CG, Sedlacek L, Gordon DL, Dendinger J, Love BB, Struck LK, Mueller C: Classification of subtype of acute ischemic stroke: definitions for use in a multicenter clinical trial. TOAST. Trial of Org 10172 in Acute Stroke Treatment. Stroke 1993;24:35-41.
15. Howard VJ, Sides EG, Newman GC, Cohen SN, Howard G, Malinow MR, Toole JF: Changes in plasma homocyst(e)ine in the acute phase after stroke. Stroke 2002;33:473-478.
16. Arnold M, Kappeler L, Georgiadis D, Berthet K, Bousser MG, Baumgartner RW: Gender differences in spontaneous cervical artery dissection. Neurology 2006;67:1050-1052.
17. Kawachi I, Colditz GA, Stampfer MJ, Willett WC, Manson JE, Rosner B, Speizer FE, Hennekens CH: Smoking cessation and time-course of decreased risk of coronary heart-disease in middle-aged women. Arch Intern Med 1994;138:169-175.
18. Lindgren A, Brattstrom L, Norrving B, Hultberg B, Andersson A, Johansson BB: Plasma homocysteine in the Acute and convalescent phases after stroke. Stroke 1995;26:795-800.
19. Brattstrom L, Wilcken DE: Homocysteine and cardiovascular disease: cause or effect? Am J Clin Nutr 2000;72:315-323.
20. Christen WG, Ajani UA, Glynn RJ, Hennekens CH: Blood levels of homocysteine and increased risks of cardiovascular disease: causal or casual? Arch Intern Med 2000;160:422-434.
21. Grau AJ, Brandt T, Forsting M, Winter R, Hacke W: Infection-associated cervical artery dissection: three cases. Stroke 1997;28:453-455.
22. Guillon B, Levy C, Bousser MG: Internal carotid artery dissection: an update. J Neurol Sci 1998;153:146-158.
23. Nurk E, Tell GS, Nygard O, Refsum H, Ueland PM, Vollset SE: Plasma total homocysteine is influenced by prandial status in humans. The Hordaland Homocysteine Study. J Nutr 2001;131:1214-1216.
24. Ubbink JB, Vermaak WJ, Van der Merwe A, Becker PJ: The effect of blood sample aging and food consumption on plasma total homocysteine levels. Clin Chim Acta 1992;207:119-128.
25. Nygard O, Vollset SE, Refsum H, Stensvold I, Tverdal A, Nordrehaug JE, Ueland M, Kvale G: Total plasma homocysteine and cardiovascular risk profile. The Hordaland Homocysteine Study. JAMA 1995;274:1526-1533.
26. Must A, Jacques PF, Rogers G, Rosenberg IH, Selhub J: Serum total homocysteine concentrations in children and adolescents: results from the third National Health and Nutrition Examination Survey (NHANES III). J Nutr 2003;133:2643-2649.
27. Jacques PF, Bostom AG, Wilson PW, Rich S, Rosenberg IH, Selhub J: Determinants of plasma total homocysteine concentration in the Framingham Offspring cohort. Am J Clin Nutr 2001;73:613-621.
28. Jacques PF, Rosenberg IH, Rogers G, Selhub J, Bowman BA, Gunter EW, Wright JD, Johnson CL: Serum total homocysteine concentrations in adolescent and adult Americans: results from the third National Health and Nutrition Examination Survey. Am J Clin Nutr 1999;69:482-489.
29. Bushnell CD, Goldstein LB: Homocysteine testing in patients with acute ischemic stroke. Neurology 2002;59:1541-1546.
30. Thom T, Haase N, Rosamond W, Howard VJ, Rumsfeld J, Manolio T, Zheng ZJ, Flegal K, Donnell C, Kittner S, Lloyd-Jones D, Goff DC Jr, Hong Y, Members of the Statistics Committee and Stroke Statistics Subcommittee, Adams R, Friday G, Furie K, Gorelick P, Kissela B, Marler J, Meigs J, Roger V, Sidney S, Sorlie P, Steinberger J, Wasserthiel-Smoller S, Wilson M, Wolf P: Heart Disease and Stroke Statistics - 2006 Update. A Report From the American Heart Association Statistics Committee and Stroke Statistics Subcommittee. Circulation 2006;113:e85-e151.
31. Rubinstein SM, Peerdeman SM, van Tulder MW, Riphagen I, Haldeman S: A systematic review of the risk factors for cervical artery dissection. Stroke 2005;36:1575-1580.
32. Baumgartner RW, Arnold M, Baumgartner I, Mosso M, Gonner F, Studer A, Schroth G, Schuknecht B, Sturzenegger M: Carotid dissection with and without ischemic events: local symptoms and cerebral artery findings. Neurology 2001;57:827-832.
33. Soriente L, Coppola A, Madonna P, Cerbone AM, Di Minno G, Orefice G, D'Angelo A, Markus HS: Homozygous C677T mutation of the 5,10 methylenetetrahydrofolate reductase gene and hyperhomocysteinemia in Italian patients with a history of early-onset ischemic stroke. Stroke 1998;29:869-871.