Experimental study of wet granulation in fluidized bed: Impact of the binder properties on the granule morphology

International Journal of Pharmaceutics

Volumn 334, Issue 1-2, 2007, Pages 92-102

  Rajniak, P ^a   Mancinelli, C ^a   Chern, R T ^a   Stepanek, F ^b   Farber, L ^a   Hill, B T ^a  

^a MERCK RESEARCH LABORATORIES   (United States)

^b IMPERIAL COLLEGE LONDON   (United Kingdom)

Author keywords

Coating; Fluid bed granulation; Growth mechanism; Physicochemical properties

Indexed keywords

CALCIUM PHOSPHATE DIBASIC; EXCIPIENT; HYDROXYPROPYLCELLULOSE; MANNITOL; PEARLITOL; UNCLASSIFIED DRUG;

AQUEOUS SOLUTION; ARTICLE; BINDING KINETICS; CHEMICAL REACTION; CONCENTRATION (PARAMETERS); DILUTION; DRUG SOLUBILITY; FLUIDIZED BED; MORPHOLOGY; PARTICLE SIZE; PHYSICAL CHEMISTRY; PRIORITY JOURNAL; VISCOSITY; WET GRANULATION; X RAY ANALYSIS;

CALCIUM PHOSPHATES; CELLULOSE; CHEMISTRY, PHARMACEUTICAL; CHEMISTRY, PHYSICAL; CHROMATOGRAPHY, ION EXCHANGE; EXCIPIENTS; MANNITOL; PHARMACEUTICAL PREPARATIONS; POROSITY; TOMOGRAPHY, X-RAY;

EID: 33947222473     PISSN: 03785173     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ijpharm.2006.10.040     Document Type: Article

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