Inhibition of hemolysate-induced iNOS and COX-2 expression by genistein through suppression of NF-k{cyrillic}B activation in primary astrocytes

Journal of the Neurological Sciences

Volumn 278, Issue 1-2, 2009, Pages 91-95

  Lu, Hua ^a   Shi, Ji Xin ^a   Zhang, Dong Mei ^b   Wang, Han Dong ^a   Hang, Chun Hua ^a   Chen, Hui Lin ^a   Yin, Hong Xia ^a  

^a JINLING HOSPITAL   (China)

^b NANJING UNIVERSITY   (China)

Author keywords

Astrocyte; COX 2; Genistein; Hemolysate; iNOS; NF k cyrillic B

Indexed keywords

CYCLOOXYGENASE 2; GENISTEIN; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INDUCIBLE NITRIC OXIDE SYNTHASE; MESSENGER RNA;

ANIMAL CELL; ANIMAL TISSUE; ANTIINFLAMMATORY ACTIVITY; ARTICLE; ASTROCYTE; CELL ASSAY; CELL VIABILITY; CONTROLLED STUDY; ENZYME INHIBITION; GENE INACTIVATION; HEMOLYSATE; NERVE CELL CULTURE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PROTEIN INTERACTION; PROTEIN SYNTHESIS INHIBITION; RAT; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; TRANSCRIPTION REGULATION;

ANIMALS; ANTI-INFLAMMATORY AGENTS; ASTROCYTES; BLOTTING, WESTERN; CELL SURVIVAL; CELLS, CULTURED; CYCLOOXYGENASE 2; GENISTEIN; NF-KAPPA B; NITRIC OXIDE SYNTHASE TYPE II; RATS; RATS, SPRAGUE-DAWLEY; RNA, MESSENGER;

EID: 58749101482     PISSN: 0022510X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jns.2008.12.007     Document Type: Article

References (34)

1. Provencio J.J., and Vora N. Subarachnoid hemorrhage and inflammation: bench to bedside and back. Semin Neurol 25 (2005) 435-444
2. Wasserman J.K., Zhu X., and Schlichter L.C. Evolution of the inflammatory response in the brain following intracerebral hemorrhage and effects of delayed minocycline treatment. Brain Res 1180 (2007) 140-154
3. Heiss E., Herhaus C., Klimo K., Bartsch H., and Gerhauser C. Nuclear factor kappa B is a molecular target for sulforaphane-mediated anti-inflammatory mechanisms. J Biol Chem 276 (2001) 32008-32015
4. Moncada S., Palmer R.M., and Higgs E.A. Nitric oxide: physiology, pathophysiology, and pharmacology. Pharmacol Rev 43 (1991) 109-142
5. Yun H.Y., Dawson T.T., and Dawson T.M. Neurobiology of nitric oxide. Crit Rev Neurobiol 10 (1996) 291-316
6. MacMicking J., Xie Q.W., and Nathan C. Nitric oxide and macrophage function. Annu Rev Immunol 15 (1997) 323-350
7. Feng L., Xia Y., Garcia G.E., Hwang D., and Wilson C.B. Involvement of reactive oxygen intermediates in cyclooxygenase-2 expression induced by interleukin-1, tumor necrosis factor-alpha, and lipopolysaccharide. J Clin Invest 95 (1995) 1669-1675
8. Smith W.L., and Langenbach R. Why there are two cyclooxygenase isozymes. J Clin Invest 107 (2001) 1491-1495
9. Crofford L.J., Lipsky P.E., Brooks P., Abramson S.B., Simon L.S., and van de Putte L.B. Basic biology and clinical application of specific cyclooxygenase-2 inhibitors. Arthritis Rheum 43 (2000) 4-13
10. Brown G.C. Mechanisms of inflammatory neurodegeneration: iNOS and NADPH oxidase. Biochem Soc Trans 35 (2007) 1119-1121
11. Shin M.C., Jang M.H., Chang H.K., Kim Y.J., Kim E.H., and Kim C.J. Modulation of cyclooxygenase-2 on glycine- and glutamate-induced ion currents in rat periaqueductal gray neurons. Brain Res Bull 59 (2003) 251-256
12. Havsteen B.H. The biochemistry and medical significance of the flavonoids. Pharmacol Ther 96 (2002) 67-202
13. Kao T.H., Wu W.M., Hung C.F., Wu W.B., and Chen B.H. Anti-inflammatory effects of isoflavone powder produced from soybean cake. J Agric Food Chem 55 (2007) 11068-11079
14. Middleton Jr. E., Kandaswami C., and Theoharides T.C. The effects of plant flavonoids on mammalian cells: implications for inflammation, heart disease, and cancer. Pharmacol Rev 52 (2000) 673-751
15. Hooshmand S., Soung do Y., Lucas E.A., Madihally S.V., Levenson C.W., and Arjmandi B.H. Genistein reduces the production of proinflammatory molecules in human chondrocytes. J Nutr Biochem 18 (2007) 609-614
16. McCarthy K.D., and de Vellis J. Preparation of separate astroglial and oligodendroglial cell cultures from rat cerebral tissue. J Cell Biol 85 (1980) 890-902
17. Murakami K., Nakamura Y., and Yoneda Y. Potentiation by ATP of lipopolysaccharide-stimulated nitric oxide production in cultured astrocytes. Neuroscience 117 (2003) 37-42
18. Iwabuchi S., Marton L.S., and Zhang J.H. Role of protein tyrosine phosphorylation in erythrocyte lysate-induced intracellular free calcium concentration elevation in cerebral smooth-muscle cells. J. Neurosurg 90 (1999) 127-135
19. Liang Y.C., Huang Y.T., Tsai S.H., Lin-Shiau S.Y., Chen C.F., and Lin J.K. Suppression of inducible cyclooxygenase and inducible nitric oxide synthase by apigenin and related flavonoids in mouse macrophages. Carcinogenesis 20 10 (1999) 1945-1952
20. Øvrevik J., Låg M., Schwarze P., and Refsnes M. p38 and Src-ERK1/2 pathways regulate crystalline silica-induced chemokine release in pulmonary epithelial cells. Toxicol Sci 81 (2004) 480-490
21. Corbett J.A., Kwon G., Marino M.H., Rodi C.P., Sullivan P.M., Turk J., et al. Tyrosine kinase inhibitors prevent cytokine-induced expression of iNOS and COX-2 by human islets. Am J Physiol 270 6 Pt 1 (1996) C1581-C1587
22. Murakami A., Matsumoto K., Koshimizu K., and Ohigashi H. Effects of selected food factors with chemopreventive properties on combined lipopolysaccharide- and interferon-gamma-induced IkappaB degradation in RAW264.7 macrophages. Cancer Lett 195 1 (2003) 17-25
23. Liao C.H., Ho C.T., and Lin J.K. Effects of garcinol on free radical generation and NO production in embryonic rat cortical neurons and astrocytes. Biochem Biophys Res Commun 329 (2005) 1306-1314
24. Blanco A.M., Pascual M., Valles S.L., and Guerri C. Ethanol-induced iNOS and COX-2 expression in cultured astrocytes via NF-kappa B. Neuroreport 15 (2004) 681-685
25. Lee S.Y., Son D.J., Lee Y.K., Lee J.W., Lee H.J., Yun Y.W., et al. Inhibitory effect of sesaminol glucosides on lipopolysaccharide-induced NF-kappaB activation and target gene expression in cultured rat astrocytes. Neurosci Res 56 (2006) 204-212
26. Park M.H., Song H.S., Kim K.H., Son D.J., Lee S.H., Yoon D.Y., et al. Cobrotoxin inhibits NF-kappa B activation and target gene expression through reaction with NF-kappa B signal molecules. Biochemistry 44 832 (2005) 6-36
27. Kim D.H., Kim C.H., Kim M.S., Kim J.Y., Jung K.J., Chung J.H., et al. Suppression of age-related inflammatory NF-kappaB activation by cinnamaldehyde. Biogerontology 8 (2007) 545-554
28. Comalada M., Ballester I., Bailón E., Sierra S., Xaus J., Gálvez J., et al. Inhibition of pro-inflammatory markers in primary bone marrow-derived mouse macrophages by naturally occurring flavonoids: analysis of the structure-activity relationship. Biochem Pharmacol 72 (2006) 1010-1021
29. Luo S.F., Lin W.N., Yang C.M., Lee C.W., Liao C.H., Leu Y.L., et al. Induction of cytosolic phospholipase A2 by lipopolysaccharide in canine tracheal smooth muscle cells: involvement of MAPKs and NF-kappaB pathways. Cell Signal 18 (2006) 1201-1211
30. Huang W.C., Chen J.J., Inoue H., and Chen C.C. Tyrosine phosphorylation of I-kappa B kinase alpha/beta by protein kinase C-dependent c-Src activation is involved in TNF-alpha-induced cyclooxygenase-2 expression. J Immunol 170 (2003) 4767-4775
31. Hämäläinen M., Nieminen R., Vuorela P., Heinonen M., and Moilanen E. Anti-inflammatory effects of flavonoids: genistein, kaempferol, quercetin, and daidzein inhibit STAT-1 and NF-kappaB activations, whereas flavone, isorhamnetin, naringenin, and pelargonidin inhibit only NF-kappaB activation along with their inhibitory effect on iNOS expression and NO production in activated macrophages. Mediators Inflamm (2007) 45673-45683
32. Baeuerle P.A., and Baltimore D. NF-kappa B: ten years after. Cell 87 (1996) 13-20
33. Kang J.L., Lee H.W., Kim H.J., Lee H.S., Castranova V., Lim C.M., and Koh Y. Inhibition of SRC tyrosine kinases suppresses activation of nuclear factor-kappaB, and serine and tyrosine phosphorylation of IkappaB-alpha in lipopolysaccharide-stimulated raw 264.7 macrophages. J Toxicol Environ Health A 68 (2005) 1643-1662
34. Tsai T.H. Concurrent measurement of unbound genistein in the blood, brain and bile of anesthetized rats using microdialysis and its pharmacokinetic application. J Chromatogr A 1073 (2005) 317-322