Sub-2 μm HPLC coupled with sub-ppm mass accuracy for analysis of pharmaceutical compound libraries

Journal of Separation Science

Volumn 31, Issue 21, 2008, Pages 3698-3703

  Stroh, Justin G ^a   Petucci, Christopher J ^a   Brecker, Scott J ^a   Nogle, Lisa M ^a  

^a PFIZER INC   (United States)

Author keywords

Accurate mass; Pharmaceutical compound libraries; Rapid LC

Indexed keywords

ACCURATE MASS; COLUMN TEMPERATURE; ELEMENTAL COMPOSITIONS; ELEVATED TEMPERATURE; HIGH-THROUGHPUT; MASS ACCURACY; PARTICLE COLUMN; PEAK WIDTHS; PHARMACEUTICAL COMPOUNDS; RAPID ANALYSIS; RAPID LC; TECHNOLOGICAL ADVANCES; TOF MASS SPECTROMETER; ULTRA-PERFORMANCE LC;

MANUFACTURE;

LIBRARIES;

DRUG;

ARTICLE; CHEMICAL STRUCTURE; FACTUAL DATABASE; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; INSTRUMENTATION; MASS SPECTROMETRY; METHODOLOGY; MOLECULAR WEIGHT; PHARMACEUTICS;

CHROMATOGRAPHY, HIGH PRESSURE LIQUID; DATABASES, FACTUAL; MASS SPECTROMETRY; MOLECULAR STRUCTURE; MOLECULAR WEIGHT; PHARMACEUTICAL PREPARATIONS; TECHNOLOGY, PHARMACEUTICAL;

EID: 58749093733     PISSN: 16159306     EISSN: 16159314     Source Type: Journal    
DOI: 10.1002/jssc.200800399     Document Type: Article

References (22)

1. Wife, R. L., Tijhuis, J., Drug Discov. Dev. 2007, 2, 265-277.
2. Swartz, M. E., J. Liquid Chromatogr. 2005, 28, 1253-1263.
3. Frank, M., LC-GC North Am. 2006, 24, 15-22.
4. Makarov, A., Denisov, E., Kholomeev, A., Balschun, W., Lange, O., Strupat, K., Horning, S., Anal. Chem. 2006, 78, 2113-2120.
5. Makarov, A., Denisov, E., Lange, O., Horning, S., J. Am. Soc. Mass Spectrom. 2006, 17, 1758.
6. Crockford, D. J., Lindon, J. C., Cloarec, O., Plumb, R. S., Bruce, S. J., Zirah, S., Rainville, P., Stumpf, C. L., Johnson, K., Holmes, E., Nicholson, J. K., Anal. Chem. 2006, 78, 4398-4408.
7. Farre, M., Kuster, M., Brix, R., Rubio, F., Lopez de Alda, M.-J., Barcelo, D., J. Chromatogr. A 2007, 1160, 166-175.
8. Grata, E., Boccard, J., Glauser, G., Carrupt, P.-A., Farmer, E. E., Wolfender, J.-L., Rudaz, S., J. Sep. Sci. 2007, 30, 2268-2278.
9. Inagaki, S., Noda, T., Min, J. Z., Toyo'oka, T., J. Chromatogr. A 2007, 1176, 94-99.
10. Kawanishi, H., Toyo'oka, T., Ito, K., Maeda, M., Hamada, T., Fukushima, T., Kato, M., Inagaki, S., J. Chromatogr. A 2006, 1132, 148-156.
11. Korir, A. K., Limtiaco, J. F. K., Gutierrez, S. M., Larive, C. K., Anal. Chem. 2008, 80, 1297-1306.
12. Kurihara, T., Min, J. Z., Toyo'oka, T., Fukushima, T., Inagaki, S., Anal. Chem. 2007, 79, 8694-8698.
13. Lenz, E. M., Williams, R. E., Sidaway, J., Smith, B. W., Plumb, R. S., Johnson, K. A., Rainville, P., Shockcor, J., Stumpf, C. L., Granger, J. H., Wilson, I. D., J. Pharm. Biomed. Anal. 2007, 44, 845-852.
14. Min, J. Z., Toyo'oka, T., Kurihara, T., Kato, M., Fukushima, T., Inagaki, S., Biomed. Chromatogr. 2007, 21, 852-860.
15. Petrovic, M., Gros, M., Barcelo, D., J. Chromatogr. A 2006, 1124, 68-81.
16. Wang, J., Leung, D., Rapid Commun. Mass Spectrom. 2007, 21, 3213-3222.
17. Zhao, X., Wang, W., Wang, J., Yang, J., Xu, G., J. Sep. Sci. 2006, 29, 2444-2451.
18. Stroh, J. G., Petucci, C. J., Brecker, S. J., Huang, N., Lau, J. M., J. Am. Soc. Mass Spectrom. 2007, 18, 1612-1616.
19. Plumb, R., Castro-Perez, J., Granger, J., Beattie, I., Joncour, K., Wright, A., Rapid Commun. Mass Spectrom. 2004, 18, 2331-2337.
20. Zhu, C., Goodall, D. M., Wren, S. A. C., LC-GC North Am. 2005, 23, 54-72.
21. Greibrokk, T., Andersen, T., J. Chromatogr. A 2003, 1000, 743-755.
22. Rubnov, S., Levy, D., Schneider, H., J. Pharm. Biomed. Anal. 1999, 18, 939-945.