DNA and chromosomal damage in response to intermittent extremely low-frequency magnetic fields

Mutation Research - Genetic Toxicology and Environmental Mutagenesis

Volumn 672, Issue 2, 2009, Pages 82-89

  Burdak Rothkamm, Susanne ^a,c   Rothkamm, Kai ^a,b   Folkard, Melvyn ^a   Patel, Gaurang ^c   Hone, Pat ^b   Lloyd, David ^b   Ainsbury, Liz ^b   Prise, Kevin M ^c  

^a MOUNT VERNON HOSPITAL   (United Kingdom)

^b PUBLIC HEALTH ENGLAND   (United Kingdom)

^c QUEEN'S UNIVERSITY BELFAST   (United Kingdom)

Author keywords

H2AX assay; Alkaline comet assay; Chromosome aberrations; DNA damage; Magnetic field; Micronuclei

Indexed keywords

ARTICLE; CHROMOSOME ABERRATION; CHROMOSOME DAMAGE; COMET ASSAY; CONTROLLED STUDY; DNA DAMAGE; DNA STRAND BREAKAGE; FIBROBLAST; HUMAN; HUMAN CELL; IONIZING RADIATION; MAGNETIC FIELD; MICRONUCLEUS; PRIORITY JOURNAL; SISTER CHROMATID EXCHANGE; X RAY;

CELL LINE; CHROMOSOME ABERRATIONS; COMET ASSAY; DNA DAMAGE; ELECTROMAGNETIC FIELDS; HUMANS;

SOLENOIDEA;

EID: 58649103973     PISSN: 13835718     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.mrgentox.2008.10.016     Document Type: Article

References (25)

1. Lacy-Hulbert A., Metcalfe J.C., and Hesketh R. Biological responses to electromagnetic fields. FASEB J 12 (1998) 395-420
2. McCann J. Cancer risk assessment of extremely low frequency electric and magnetic fields: a critical review of methodology. Environ. Health Perspect. 106 (1998) 701-717
3. Vijayalaxmi, and Obe G. Controversial cytogenetic observations in mammalian somatic cells exposed to extremely low frequency electromagnetic radiation: a review and future research recommendations. Bioelectromagnetics 26 (2005) 412-430
4. Hone P., Edwards A., Halls J., Cox R., and Lloyd D. Possible associations between ELF electromagnetic fields, DNA damage response processes and childhood leukaemia. Br. J. Cancer 88 (2003) 1939-1941
5. Michael B., Prise K., Folkard M., Mitchell S., and Gilchrist S. Effects of 50 Hz magnetic field exposure on mammalian cells in culture. In: Clements-Croome D. (Ed). Electromagnetic, Environments and Health in Buildings, Conference (2004), Taylor & Francis, London 307-312
6. Ivancsits S., Diem E., Pilger A., Rudiger H.W., and Jahn O. Induction of DNA strand breaks by intermittent exposure to extremely-low-frequency electromagnetic fields in human diploid fibroblasts. Mutat. Res. 519 (2002) 1-13
7. Ivancsits S., Diem E., Jahn O., and Rudiger H.W. Intermittent extremely low frequency electromagnetic fields cause DNA damage in a dose-dependent way. Int. Arch. Occup. Environ Health 76 (2003) 431-436
8. Ivancsits S., Diem E., Jahn O., and Rudiger H.W. Age-related effects on induction of DNA strand breaks by intermittent exposure to electromagnetic fields. Mech. Ageing Dev. 124 (2003) 847-850
9. Ivancsits S., Pilger A., Diem E., Jahn O., and Rudiger H.W. Cell type-specific genotoxic effects of intermittent extremely low-frequency electromagnetic fields. Mutat. Res. 583 (2005) 184-188
10. Winker R., Ivancsits S., Pilger A., Adlkofer F., and Rudiger H.W. Chromosomal damage in human diploid fibroblasts by intermittent exposure to extremely low-frequency electromagnetic fields. Mutat. Res. 585 (2005) 43-49
11. Rogakou E.P., Pilch D.R., Orr A.H., Ivanova V.S., and Bonner W.M. DNA double-stranded breaks induce histone H2AX phosphorylation on serine 139. J. Biol. Chem. 273 (1998) 5858-5868
12. Rogakou E., Boon C., Redon C., and Bonner W. Megabase chromatin domains involved in DNA double-strand breaks in vivo. J. Cell. Biol. 146 (1999) 905-916
13. Rothkamm K., and Löbrich M. Evidence for a lack of DNA double-strand break repair in human cells exposed to very low X-ray doses. Proc. Natl. Acad. Sci. U.S.A. 100 (2003) 5057-5062
14. IAEA, Cytogenetic Analysis for Radiation Dose Assessment, A Manual, Tech Rept Series, 405, International Atomic Energy Agency, Vienna, 2001.
15. Vijayalaxmi, J.P. McNamee, M.R. Scarfi, Comments on: "DNA strand breaks" by Diem et al. [Mutat. Res. 583 (2005) 178-183] and Ivancsits et al. [Mutat. Res. 583 (2005) 184-188], Mutat Res 603 (2006) 104-106.
16. Scarfi M.R., Sannino A., Perrotta A., Sarti M., Mesirca P., and Bersani F. Evaluation of genotoxic effects in human fibroblasts after intermittent exposure to 50Hz electromagnetic fields: a confirmatory study. Radiat. Res. 164 (2005) 270-276
17. Burdak-Rothkamm S., Short S.C., Folkard M., Rothkamm K., and Prise K.M. ATR-dependent radiation-induced gammaH2AX foci in bystander primary human astrocytes and glioma cells. Oncogene 26 (2007) 993-1002
18. Sokolov M.V., Smilenov L.B., Hall E.J., Panyutin I.G., Bonner W.M., and Sedelnikova O.A. Ionizing radiation induces DNA double-strand breaks in bystander primary human fibroblasts. Oncogene 24 (2005) 7257-7265
19. Yang H., Asaad N., and Held K.D. Medium-mediated intercellular communication is involved in bystander responses of X-ray-irradiated normal human fibroblasts. Oncogene 24 (2005) 2096-2103
20. Hu B., Wu L., Han W., Zhang L., Chen S., Xu A., Hei T.K., and Yu Z. The time and spatial effects of bystander response in mammalian cells induced by low dose radiation. Carcinogenesis 27 (2006) 245-251
21. Han W., Wu L., Chen S., Bao L., Zhang L., Jiang E., Zhao Y., Xu A., Hei T.K., and Yu Z. Constitutive nitric oxide acting as a possible intercellular signaling molecule in the initiation of radiation-induced DNA double strand breaks in non-irradiated bystander cells. Oncogene 26 (2007) 2330-2339
22. Barber R.C., Hickenbotham P., Hatch T., Kelly D., Topchiy N., Almeida G.M., Jones G.D., Johnson G.E., Parry J.M., Rothkamm K., and Dubrova Y.E. Radiation-induced transgenerational alterations in genome stability and DNA damage. Oncogene 25 (2006) 7336-7342
23. Barber P.B., Locke R.J., Pierce G.P., Rothkamm K., and Vojnovic B. Gamma-H2AX foci counting: image processing and control software for high-content screening. Proc. SPIE (2007) 6441
24. Rothkamm K., Balroop S., Shekhdar J., Fernie P., and Goh V. Leukocyte DNA damage after multi-detector row CT: a quantitative biomarker of low-level radiation exposure. Radiology 242 (2007) 244-251
25. IARC. Extremely Low-Frequency Electric and Magnetic Fields: IACR Monographs on the Evaluation of Carcinogenic Risk to Humans vol. 80 (2002), International Agency for Research on Cancer, Lyon