Protective effect of Withaferin-A on micronucleus frequency and detoxication agents during experimental oral carcinogenesis

African Journal of Traditional, Complementary and Alternative Medicines

Volumn 6, Issue 1, 2009, Pages 1-8

  Panjamurthy, Kuppusamy ^a   Manoharan, Shanmugam ^a   Balakrishnan, Subramanian ^a   Suresh, Kathiresan ^a   Nirmal, Madhavan R ^a   Senthil, Namasivayam ^a   Alias, Linsa Marry ^a  

^a ANNAMALAI UNIVERSITY   (India)

Author keywords

Detoxication; DMBA; Micronucleus; Oral cancer; Withaferin A

Indexed keywords

DIMETHYLBENZ[A]ANTHRACENE; PARAFFIN; WITHAFERIN A;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BONE MARROW CELL; CANCER GROWTH; CARCINOGENESIS; CELL PROTECTION; CHEEK POUCH; CONTROLLED STUDY; DRUG EFFECT; DRUG EFFICACY; DRUG ISOLATION; DRUG STRUCTURE; ERYTHROCYTE; MALE; MICRONUCLEUS TEST; MOUTH CARCINOMA; NONHUMAN; SQUAMOUS CELL CARCINOMA; TREATMENT OUTCOME;

EID: 58649090036     PISSN: 01896016     EISSN: 01896016     Source Type: Journal    
DOI: None     Document Type: Article

References (24)

1. Anderson, M.E. (1985). Determination of glutathione and glutathione disulfide in biological samples. In: Meister A, editor. Methods in enzymology.. New York: Academic press. Vol. 113:P.548-551.
2. Aruna, K., Sivaramakrishnan, V.M. (1990). Plant products protective against cancer. Indian J Exp Biol. 26: 1008-1011.
3. Bargagna-Mohan, P., Hamza, A., Kim, Y., Ho, Y.K., Mor-Vaknin, N., Wendschlag, N., Liu, J., Evans, R.M., Markovitz, D.M., Zhan, C., Kim, K.B. and Mohan, R. (2007). The tumor inhibitor and antiangiogenic agent withaferin A targets the intermediate filament protein vimentin. Chem Biol. 14: 623-634.
4. Beutler, E., Kelly, B.M. (1963). The effect of sodium nitrate on RBC glutathione. Experimentia. 19: 96-97.
5. Bhattacharya, S.K., Satyan, K.S., Ghosal, S. (1997). Antioxidant activity of glycowithanolides from Withania somnifera. Indian J Exp Biol. 35: 236-39.
6. Bhuvanesvari, V., Abraham, S.K. and Nagini, S. (2005). Combinatorial antigenotoxic effects of tomato and garlic through modulation of xenobiotic-metabolizing enzymes during hamster buccal pouch carcinogenesis. Nutrition.21: 726-731.
7. Chandramohan, K.V.P., Kumaragubaran, R., Prathiba, D. and Nagini, S. (2006). Modulation of xenobiotic-metaboliing enzymes and redox status during chemoprevention of hamster buccal pouch carcinogenesis by bovine lactofrin. Nutrition. 22: 940-946.
8. 53 and Ha-ras mutations in chemically induced hamster buccal pouch carcinomas. Carcinogenesis. 17: 595-600.
9. Dasgupta, T., Rao, A.R., Yadav, P.K. (2004). Chemomodulatory efficacy of Basil leaf (Ocimum basilicum) on drug metabolizing and antioxidant enzymes, and on carcinogen induced skin and forestomach papillomagenesis. Phytomedicine. 11: 139-151.
10. Davis, L., Kuttan, G. (2000). Immunomodulatory activity of Withania somnifera. J. Ethnopharmacol. 71: 193-200.
11. Davis, L., Kuttan, G. (2001). Effects of Withania somnifera on DMBA induced carcinogenesis. J Ethanopharmacol. 75: 165-168.
12. Habig, W.H., Pabst, M.J. and Jakoby, W.B. (1994). Glutathione-S-transferase the first enzymatic step in mercapturic acid formation. J Biol Chem. 249:7130-7139.
13. Hodgson, E. (2000). In vitro human phase I metabolism of xenobiotics I: pesticides and related chemicals used in agriculture and public health. J Biochem Mol Toxicol. 15:296-299.
14. Miyamoto, C.T., Sant'anna, J.R., Franco, C.C., Castro-Prado, M.A. (2007). Genotoxicity (mitotic recombination) of the cancer chemotherapeutic agents, cisplatin and cytosine arabinoside in Aspergillus nidulans. Food Chem Toxicol. 45: 1091-1095.
15. Miyata, M., Furukawa, M., Takahasi, K., Gonzalez, F.J. and Yamazoe, Y. (2001). Mechanism of 7, 12-dimethylbenz(a) anthracene induced immunotoxicity: Role of Metabolic activation at the target organ. Jpn J pharmacol. 86: 302-309.
16. Morita, T., Asano, N., Awogi, T., Sasaki, Y.F., Sato, S., Shimada, H., Sutou, S. (1997). Evaluation of the rodent micronucleus assay in the screening of IARC carcinogens (groups 1, 2A and 2B) the summary report of the 6th collaborative study by CSGMT/JEMS MMS. Collaborative study of the micronucleus group test. Mammalian Mutagenicity Study Group, Mutat Res. 389: 3-122.
17. Osaka, M., Matsus, S., Koh, T., Sugiyama, T. (1996). Specific N-ras Mutation in bone marrow with in 48 hours of DMBA - treatment in Huggins-sugiyama Rat leukemogenesis. Mol. Carcinogenesis 16: 126-131.
18. Schmid, W. (1975). The micronucleus test. Mutat Res. 31: 9-15.
19. Schwartz, J.L., Shklar, G. (1996). Glutathione inhibits experimental oral carcinogenesis, p53 expression, and angiogenesis. Nutr Cancer. 26: 229-236.
20. Senthil, N., Manoharan, S., Balakrishnan, S., Ramachandran, C.R., and Muralinaidu, R. (2007). Chemopreventive and antilipidperoxidative efficacy of Piper longum (Linn.) on 7, 12-dimethylbenz(a)anthracene (DMBA) induced hamster buccal pouch carcinogenesis. J Appl Sci. 7: 1036-1042.
21. Sharada, A.C., Solomon, F.E., Devi, P.U., Udupa, N. and Srinivasan, K.K. (1996). Antitumor and radiosensitizing effects of Withaferin - A on mouse Ehrlich ascites carcinoma in vivo. Acta Oncol. 35: 95-100.
22. Shklar, G. (1999). Development of experimental oral carcinogenesis and its impact on current oral cancer research. J. Dent. Res. 78: 1768-1772.
23. Subramanian, S.S. and Sethi, P.D. (1969). Withaferin - A from Withania somnifera coagulants roots. Current science (India). 38: 267-68.
24. Yang, H., Shi, G. and Dou, P. (2007). The tumor proteasome is a primary target for the natural anticancer compound Withaferin A isolated from "Indian winter cherry". Mol. Pharmacol. 71: 426-437.