A small molecule inhibitor selective for a variant ATP-binding site of the chaperonin GroEL

Bioorganic and Medicinal Chemistry Letters

Volumn 19, Issue 3, 2009, Pages 811-813

  Chapman, Eli ^a   Farr, George W ^b   Furtak, Krystyna ^b   Horwich, Arthur L ^a,b  

^a SCRIPPS RESEARCH INSTITUTE   (United States)

^b YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

ATPase inhibitor; Chaperone; Chaperonin; Chemical genetics; GroEL

Indexed keywords

ADENOSINE TRIPHOSPHATASE; ADENOSINE TRIPHOSPHATE; AMIDE; CHAPERONIN; CYCLOPENTANE DERIVATIVE; EC 3016; MUTANT PROTEIN; PHOSPHOTRANSFERASE INHIBITOR; PYRAZOLE DERIVATIVE; PYRIMIDINE DERIVATIVE; UNCLASSIFIED DRUG;

ARTICLE; BINDING SITE; ENZYME INHIBITION; HYDROLYSIS; MACROMOLECULE; MOLECULAR SIZE; PROTEIN FOLDING;

ADENOSINE TRIPHOSPHATE; BINDING SITES; CATALYTIC DOMAIN; CHAPERONIN 60; CHEMISTRY, PHARMACEUTICAL; DRUG DESIGN; ESCHERICHIA COLI; MODELS, CHEMICAL; MODELS, MOLECULAR; PHOSPHATES; PROTEIN BINDING; PROTEIN DENATURATION; PROTEIN FOLDING; TEMPERATURE;

BACTERIA (MICROORGANISMS);

EID: 58549119119     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2008.12.015     Document Type: Article

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