Autophagic cell death of human hepatoma cells induced by Endostar, a recombinant human endostatin

Cancer Biotherapy and Radiopharmaceuticals

Volumn 23, Issue 6, 2008, Pages 735-740

  Wu, Gang ^a   Zhang, Ruiguang ^a   Ren, Jinghua ^a   Sun, Yichen ^a  

^a UNION HOSPITAL   (China)

Author keywords

Autophagy; Endostar; Hepatocellular carcinoma

Indexed keywords

ENDOSTAR; ENDOSTATIN; MICROTUBULE ASSOCIATED PROTEIN; MICROTUBULE ASSOCIATED PROTEIN LIGHT CHAIN 3; RECOMBINANT PROTEIN; UNCLASSIFIED DRUG; YH 16;

ARTICLE; AUTOPHAGY; CANCER CELL CULTURE; CANCER GROWTH; CELL DEATH; CELL GROWTH; CELL PROLIFERATION; CELL STRAIN HEPG2; CELL VIABILITY; CONCENTRATION RESPONSE; CONFOCAL LASER MICROSCOPY; CONTROLLED STUDY; HUMAN; HUMAN CELL; LIVER CELL CARCINOMA; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN EXPRESSION; TRANSMISSION ELECTRON MICROSCOPY; WESTERN BLOTTING;

AUTOPHAGY; BLOTTING, WESTERN; CARCINOMA, HEPATOCELLULAR; CELL LINE, TUMOR; CELL PROLIFERATION; ENDOSTATINS; HUMANS; IMMUNOENZYME TECHNIQUES; LIVER NEOPLASMS; MICROTUBULE-ASSOCIATED PROTEINS; RECOMBINANT PROTEINS;

EID: 58549117493     PISSN: 10849785     EISSN: None     Source Type: Journal    
DOI: 10.1089/cbr.2008.0518     Document Type: Article

References (19)

1. Shintani T, Klionky DJ. Autophagy in health and disease: A double-edged sword. Science 2004;306:990.
2. Levine B, Kroemer G. Autophagy in the pathogenesis of disease. Cell 2008;132:27.
3. O'Reilly MS, Boehm T, Shing Y, et al. Endostatin: An endogenous inhibitor of angiogenesis and tumor growth. Cell 1997;88:277.
4. Wang J, Sun Y, Liu Y, et al. Results of randomized, multicenter, double-blind phase III trial of rh-endostatin (YH-16) in treatment of advanced non-small-cell lung cancer patients. Chin J Lung Cancer 2005;8:283.
5. Ramakrishnan S, Nguyen TMB, Subramanian IV, et al. Autophagy and angiogenesis inhibition. Autophagy 2007;3:1.
6. Chau YP, Lin SY, Chen JHC, et al. Endostatin induces autophagic cell death in EAhy926 human endothelial cells. Histol Histopathol 2003;18:715.
7. Kabeya Y, Mizushima N, Ueno T, et al. LC3, a mammalian homologue of yeast Apg8p, is localized in autophagosome membranes after processing. EMBO J 2000;19:5720; erratum in EMBO J 2003;22:4577.
8. Klionsky DJ, Emr SD. Autophagy as a regulated pathway of cellular degradation. Science 2000;290:1717.
9. Bursch W, Ellinger A, Kienzl H, et al. Active cell death induced by the antiestrogens tamoxifen and ICI 164384 in human mammary carcinoma cells (MCF-7) in culture: The role of autophagy. Carcinogenesis 1996;17:1595.
10. Kanzawa T, Kondo Y, Ito H, et al. Induction of autophagic cell death in malignant glioma cells by arsenic trioxide. Cancer Res 2003;63:2103.
11. Paglin S, Hollister T, Delohery T, et al. A novel response of cancer cells to radiation involves autophagy and formation of acidic vesicles. Cancer Res 2001;61:439.
12. Lockshin RA, Zakeri Z. Apoptosis, autophagy, and more. Int J Biochem Cell Biol 2004;36:2405.
13. Kisen GO, Tessitore L, Costelli P, et al. Reduced autophagic activity in primary rat hepatocellular carcinoma and ascites hepatoma cells. Carcinogenesis 1993;14:2501.
14. Bursch W, Hochegger K, Torok L, et al. Autophagic and apoptotic types of programmed cell death exhibit different fates of cytoskeletal filaments. J Cell Sci 2000;113:1189.
15. Ogier-Denis E, Codogno P. Autophagy: A barrier or an adaptive response to cancer. Biochem Biophys Acta 2003;1603:113.
16. Gozuacik D, Kimchi A. Autophagy as a cell death and tumor suppressor mechanism. Oncogene 2004;23:2891.
17. Wu H, Yang JM, Jin S. Elongation factor-2 kinase regulates autophagy in human glioblastoma cells. Cancer Res 2006;66:3015.
18. Mégalizzi V, Mathieu V, Mijatovic T, et al. 4-IBP, a sigma1 receptor agonist, decreases the migration of human cancer cells, including glioblastoma cells, in vitro and sensitizes them in vitro and in vivo to cytotoxic insults of proapoptotic and proautophagic drugs. Neoplasia 2007;9:358.
19. Kim YM, Hwang S, Kim YM, et al. Endostatin blocks vascular endothelial growth factor-mediated signaling via direct interaction with KDR/Flk-1. J Biol Chem 2002;277:27872.