Anti-cowpox Virus Activities of Certain Adenosine Analogs, Arabinofuranosyl Nucleosides, and 2′-Fluoro-arabinofuranosyl Nucleosides

Nucleosides, Nucleotides and Nucleic Acids

Volumn 23, Issue 1-2, 2004, Pages 375-383

  Smee, Donald F ^a   Sidwell, Robert W ^a  

^a UTAH STATE UNIVERSITY   (United States)

Author keywords

Antiviral; Bioterrorism; Cidofovir; Cowpox virus; Fialuridine; Idoxuridine; Nucleosides; Vidarabine

Indexed keywords

1 BETA DEXTRO ARABINOFURANOSYL 5 CHLOROCYTOSINE; 1 BETA DEXTRO ARABINOFURANOSYL 5 FLUOROCYTOSINE; 2' FLUOROARABINOFURANOSYL NUCLEOSIDE DERIVATIVE; 3' O METHYLADENOSINE; 8 BROMOADENOSINE; 8 CHLOROADENOSINE; 8 METHYLADENOSINE; ADENOSINE DERIVATIVE; ARABINOFURANOSYL NUCLEOSIDE DERIVATIVE; CIDOFOVIR; CLEVUDINE; CYTARABINE; FIACITABINE; FIALURIDINE; GUANINE ARABINOSIDE; IDOXURIDINE; THYMINE ARABINOSIDE; UNCLASSIFIED DRUG; VIDARABINE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIVIRAL ACTIVITY; ARTICLE; BREAST TUMOR; CANCER CELL CULTURE; CELL CULTURE; CELL PROLIFERATION; CONTROLLED STUDY; COWPOX; COWPOX VIRUS; CYTOTOXICITY; DRUG ACTIVITY; DRUG POTENCY; FEMALE; MONKEYPOX VIRUS; MOUSE; NONHUMAN; RESPIRATORY TRACT INFECTION; SMALLPOX VIRUS; SURVIVAL; VERO CELL; VIRUS INHIBITION; VIRUS PLAQUE;

ADENOSINE; ANIMALS; ANTIVIRAL AGENTS; ARABINONUCLEOTIDES; CERCOPITHECUS AETHIOPS; COWPOX; COWPOX VIRUS; FEMALE; MICE; VERO CELLS;

ANIMALIA; ARA; CERCOPITHECUS AETHIOPS; COWPOX VIRUS; MONKEYPOX VIRUS; ORTHOPOXVIRUS; VARIOLA; VARIOLA VIRUS;

EID: 1542784356     PISSN: 15257770     EISSN: None     Source Type: Journal    
DOI: 10.1081/NCN-120028334     Document Type: Article

References (24)

1. Breman, J.G.; Henderson, D.A. Poxvirus dilemmas-monkeypox, smallpox and biological terrorism. N. Engl. J. Med. 1998, 339, 556-559.
2. Peters, C.J. Many viruses are potential agents of bioterrorism. ASM News 2002, 68, 168-173.
3. Bray, M. Pathogenesis and potential antiviral therapy of complications of smallpox vaccination. Antivir. Res. 2003, 58, 101-114.
4. Ibarra, V.; Blanco, J.R.; Oteo, J.A.; Rosel, L. Efficacy of cidofovir in the treatment of recalcitrant molluscum contagiosum in an AIDS patient. Acta Derm.-Venereol. 2000, 80, 315-316.
5. Toro, J.R.; Wood, L.V.; Patel, N.K.; Turner, M.L. Topical cidofovir: a novel treatment for recalcitrant molluscum contagiosum in children infected with human immunodeficiency virus 1. Arch. Dermatol. 2000, 136, 983-985.
6. Geerinck, K.; Lukito, G.; Snoeck, R.; De Vos, R.; De Clercq, E.; Vanrenterghem, Y.; Degreef, H.; Maes, B. A case of human orf in an immunocompromised patient treated successfully with cidofovir cream. J. Med. Virol. 2001, 64, 543-549.
7. Smee, D.F.; Sidwell, R.W. A review of compounds exhibiting anti-orthopoxvirus activity in animal models. Antivir. Res. 2003, 57, 41-52.
8. Bray, M.; Martinez, M.; Smee, D.F.; Kefauver, D.; Thompson, E.; Huggins, J.W. Cidofovir (HPMPC) protects mice against lethal aerosol or intranasal cowpox virus challenge. J. Infect. Dis. 2000, 181, 10-19.
9. Smee, D.F.; Bailey, K.W.; Sidwell, R.W. Treatment of lethal vaccinia virus respiratory infections in mice with cidofovir. Antivir. Chem. Chemother. 2001, 12, 71-76.
10. Smee, D.F.; Bailey, K.W.; Wong, M.-H.; Sidwell, R.W. Effects of cidofovir on the pathogenesis of a lethal vaccinia virus respiratory infection in mice. Antivir. Res. 2001, 52, 55-62.
11. De Clercq, E. Cidofovir in the treatment of poxvirus infections. Antivir. Res. 2002, 55, 1-13.
12. Neyts, J.; De Clercq, E. Efficacy of 2-amino-7-[(1,3-dihydroxy-2-propoxy)methyl]-purine for treatment of lethal vaccinia (orthopoxvirus) virus infections in mice. Antimicrob. Agents Chemother. 2001, 45, 84-87.
13. Smee, D.F.; Bailey, K.W.; Sidwell, R.W. Treatment of lethal cowpox virus respiratory infections in mice with 2-amino-7-[(1,3-dihydroxy-2-propoxy)methyl]-purine and its orally active diacetate ester prodrug. Antivir. Res. 2002, 54, 113-120.
14. Van Aerschot, A.; Mamos, P.; Weyns, N.J.; Ikeda, S.; De Clercq, E.; Herdewijn, P. Antiviral activity of C-alkylated purine nucleosides obtained by cross-coupling with tetraalkyltin reagents. J. Med. Chem. 1993, 36, 2938-2942.
15. Goswami, B.B.; Sharma, O.K. Inhibition of vaccinia virus growth and virus-specific RNA synthesis by 3′-O-methyl adenosine and 3′-O-methyl guanosine. J. Virol. 1983, 45, 1164-1167.
16. Sloan, B.J. Adenine arabinoside: chemotherapy studies in animals. In Adenine Arabinoside: An Antiviral Agent; Pavan-Langston, D., Buchanan, R.A., Alford, C.A., Jr., Eds.; Raven Press: New York, 1975; 45-94.
17. De Clercq, E.; Luczak, M.; Shugar, D.; Torrence, P.; Waters, J.A.; Witkop, B. Effect of cytosine arabinoside, iododeoxyuridine, ethyldeoxyuridine, thiocyanato-deoxyuridine, and ribavirin on tail lesion formation in mice infected with vaccinia virus. Proc. Soc. Exp. Biol. Med. 1976, 151, 487-490.
18. Neyts, J.; Verbeken, E.; De Clercq, E. Effect of 5-iodo-2′ -deoxyuridine (IDU) against vaccinia virus (orthopoxvirus) infections in mice. Antimicrob. Agents Chemother. 2002, 46, 2842-2847.
19. Smee, D.F.; Campbell, N.L.; Matthews, T.R. Comparative anti-herpesvirus activities of 9-(1,3-dihydroxy-2-propoxymethyl)guanine, acyclovir, and two 2′-fluoropyrimidine nucleosides. Antivir. Res. 1985, 5, 259-267.
20. Neyts, J.; Meerbach, A.; De Clercq, E. Use of the yellow fever virus vaccine strain 17D for the study of strategies for the treatment of yellow fever virus infections. Antivir. Res. 1996, 30, 125-132.
21. Smee, D.F.; Bray, M.; Huggins, J.W. Antiviral activity and mode of action studies of ribavirin and mycophenolic acid against orthopoxviruses in vitro. Antivir. Chem. Chemother. 2001, 12, 327-335.
22. Dixon, G.J.; Sidwell, R.W.; Miller, F.A.; Sloan, B.J. Antiviral activity of 9-β-D-arabinofuranosyladenine. V. Activity against intracerebral vaccinia virus infections in mice. In Antimicrobial Agents and Chemotherapy-1968; Hobby, G.L., Ed.; American Society for Microbiology: Ann Arbor, MI, 1969; 172-179.
23. McKenzie, R.; Fried, M.W.; Sallie, R.; Conjeevaram, H.; Di Bisceglie, A.M.; Park, Y.; Savarese, B.; Kleiner, D.; Tsokos, M.; Luciano, C.; Pruett, T.; Stotka, J.L.; Straus, S.E.; Hoofnagle, J.H. Hepatic failure and lactic acidosis due to fialuridine (FIAU), an investigational nucleoside analogue for chronic hepatitis B. N. Engl. J. Med. 1995, 333, 1099-1105.
24. Quenelle, D.C.; Collins, D.J.; Herod, B.P.; Beadle, J.R.; Wan, W.B.; Hostetler, K.Y.; Kern, E.R. Effect of oral treatment with alkoxyalkyl esters of cidofovir on cowpox or vaccinia virus infections in mice. Antivir. Res. 2003, 57, A79.