Substituted 1,2,3,4-tetrahydroquinolin-6-yloxypropanes as β3-adrenergic receptor agonists: Design, synthesis, biological evaluation and pharmacophore modeling

Bioorganic and Medicinal Chemistry

Volumn 17, Issue 2, 2009, Pages 830-847

  Shakya, Neeraj ^a   Roy, Kuldeep K ^a   Saxena, Anil K ^a  

^a CENTRAL DRUG RESEARCH INSTITUTE   (India)

Author keywords

3 adrenergic receptor agonist; 1,2,3,4 Tetrahydroquinolin 6 yloxypropanes; Catalyst; HipHop; Obesity; Putative pharmacophore; Type II diabetes

Indexed keywords

1 (1 BENZYL 1,2,3,4 TETRAHYDROQUINOLIN 6 YLOXY) 3 [2 (3,4 DIMETHOXYPHENYL)ETHYLAMINO]PROPAN 2 OL; 1 (1 BENZYL 1,2,3,4 TETRAHYDROQUINOLIN 6 YLOXY) 3 [2 (4 METHOXYPHENYL)ETHYLAMINO]PROPAN 2 OL; 1 (1 BENZYL 1,2,3,4 TETRAHYDROQUINOLIN 6 YLOXY) 3 [4 (4 FLUOROPHENYL)PIPERAZIN 1 YL]PROPAN 2 OL; 1 (1 BENZYL 1,2,3,4 TETRAHYDROQUINOLIN 6 YLOXY) 3 ISOPROPYLAMINOPROPAN 2 OL; 1,2,3,4 TETRAHYDROQUINOLIN 6 YLOXYPROPANE DERIVATIVE; BETA 3 ADRENERGIC RECEPTOR STIMULATING AGENT; UNCLASSIFIED DRUG;

ARTICLE; CONTROLLED STUDY; DRUG DESIGN; DRUG SCREENING; DRUG SYNTHESIS; HUMAN; HUMAN CELL; IC 50; MOLECULAR MODEL; PHARMACOPHORE; STRUCTURE ACTIVITY RELATION;

ADRENERGIC AGONISTS; ANTI-OBESITY AGENTS; CELL LINE, TUMOR; DIABETES MELLITUS, TYPE 2; DRUG DESIGN; HUMANS; HYPOGLYCEMIC AGENTS; INHIBITORY CONCENTRATION 50; MODELS, MOLECULAR; NEUROBLASTOMA; QUINOLINES; RECEPTORS, ADRENERGIC, BETA-3;

EID: 58549097259     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmc.2008.11.030     Document Type: Article

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